Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kui-Hao Chen"'
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models. The present study investigates whether acacetin inhibits the Ca2+-activated pot
Externí odkaz:
https://doaj.org/article/4d5c085ac3254f2f9490651152d30ccf
Autor:
Xiao-Hui Xu, Hai-Ying Sun, Yan-Hui Zhang, Wei Wu, Kui-Hao Chen, Yi Liu, Chun-Yu Deng, Xi-Yong Yu, Man-Wen Jin, Gui-Rong Li
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51550 (2012)
Allitridi (diallyl trisulfide) is an active compound (volatile oil) from garlic. The previous studies reported that allitridi had anti-arrhythmic effect. The potential ionic mechanisms are, however, not understood. The present study was designed to d
Externí odkaz:
https://doaj.org/article/94ec8f6e397949cebf22472c9268831f
Autor:
Yan Wang, Xiao-Hui Xu, Kui-Hao Chen, Man-Wen Jin, Gui-Rong Li, Hui Liu, Lei Yang, Guo-Sheng Xiao, Hai-Ying Sun, Xin-Ling Du
Publikováno v:
Heart Rhythm. 13:762-770
Background Several mammalian species display distinct biophysical properties between atrial and ventricular voltage-gated sodium current (I Na ); however, the potential mechanism behind this phenomenon is unknown. Objective The purpose of this study
Autor:
Gui-Rong Li, Lei Yang, Guo-Sheng Xiao, Yan Wang, Kui-Hao Chen, Man-Wen Jin, Hui Liu, Hai-Ying Sun
Publikováno v:
Pharmacological Research. 104:61-69
SKF-96365 is a TRPC channel antagonist commonly used to characterize the potential functions of TRPC channels in different systems, which was recently reported to induce QTc prolongation on ECG by inhibiting TRPC channels. The present study investiga
Autor:
Feng Lin, Hui-Jun Wu, Hai-Ying Sun, Kui-Hao Chen, Gui-Rong Li, Lei Yang, Guo-Sheng Xiao, Hui Liu, Gang Li, Yan Wang
Publikováno v:
Scientific Reports
The morbidity and mortality of patients with ischemic cardiomyopathy resulted from ischemia/reperfusion injury are very high. The present study investigates whether our previously synthesized water-soluble phosphate prodrug of acacetin was cardioprot
Publikováno v:
Pflugers Archiv : European journal of physiology. 467(6)
SKF-96365 (1-(beta-[3-(4-methoxy-phenyl) propoxy]-4-methoxyphenethyl)-1H-imidazole hydrochloride) is a general TRPC channel antagonist commonly used to characterize the potential functions of TRPC channels in cardiovascular system. Recent reports sho
Publikováno v:
Journal of Cellular Physiology.
Transient receptor potential melastatin-7 (TRPM7) channels are involved in many cellular physiological and pathological processes. The present study was designed to investigate the expression of TRPM7 channels and the potential role in regulating cel
Publikováno v:
European journal of pharmacology. 713(1-3)
Pentamethylquercetin (PMQ) has been shown to possess glucose-lowering properties, but its effect on renal fibrosis in diabetes is still unclear. This study was designed to investigate the effect of PMQ on renal fibrosis and the underlying mechanisms
Publikováno v:
Frontiers in Pharmacology; 10/10/2017, p1-9, 9p
Autor:
Xiao-Hui Xu, Gui-Rong Li, Man-Wen Jin, Kui-Hao Chen, Zheng Liu, Yan Hu, Ji-Zhong Shen, Zhendong Jin, Xin-Ling Du, Yi Liu, Xin Xin
Publikováno v:
Biochemical pharmacology. 84(4)
The natural flavones and polymethylflavone have been reported to have cardiovascular protective effects. In the present study, we determined whether quecertin, apigenin and their methylated compounds (3,7,3',4'-tetramethylquecertin, 3,5,7,3',4'-penta