Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kui Ming Chan"'
Autor:
Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, Xin Wang, Y. Rebecca Chin
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recently revealed distinct super-enhan
Externí odkaz:
https://doaj.org/article/3bdf41726eb64b13ab397d8213e002d9
Autor:
Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo, Joan So, Lei Peng, Xiaoxuan Zhu, Eva Hin Wa Leung, Lina Zhu, Kui Ming Chan, Martin Cheung, Siu Yuen Chan
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Nucleosome assembly proteins (NAPs) have been identified as histone chaperons. Testis‐Specific Protein, Y‐Encoded‐Like (TSPYL) is a newly arisen NAP family in mammals. TSPYL2 can be transcriptionally induced by DNA damage and TGFβ cau
Externí odkaz:
https://doaj.org/article/5b11482ae15f4614abc925667ecbfef7
Autor:
Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeutics for obesity management. Here
Externí odkaz:
https://doaj.org/article/a29cc025e9664a529d8c924433238848
Autor:
Huazhang Zhu, Dawei Wang, Zuodong Ye, Lihong Huang, Wenjie Wei, Kui Ming Chan, Rongxin Zhang, Liang Zhang, Jianbo Yue
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains elusive. Results Her
Externí odkaz:
https://doaj.org/article/8e664f916c61404889caad51f17ef210
Autor:
Suyang Zhang, Feng Yang, Yile Huang, Liangqiang He, Yuying Li, Yi Ching Esther Wan, Yingzhe Ding, Kui Ming Chan, Ting Xie, Hao Sun, Huating Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly understood how SCs enter cell cycle to become activated upon in
Externí odkaz:
https://doaj.org/article/1c9d2d3a7ef942469a3d3cc53c2479fa
Autor:
Xuanming Guo, Jianli Cao, Jian-Piao Cai, Jiayan Wu, Jiangang Huang, Pallavi Asthana, Sheung Kin Ken Wong, Zi-Wei Ye, Susma Gurung, Yijing Zhang, Sheng Wang, Zening Wang, Xin Ge, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Nathalie Wong, Jiandong Huang, Zhongjun Zhou, Zhao-Xiang Bian, Shuofeng Yuan, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The role of soluble angiotensin converting enzyme 2 (sACE2) in SARS-CoV-2 infection is not well understood. Here, authors show that membrane type 1 matrix metalloproteinase (MT1-MMP) releases sACE2 to promote SARS-CoV-2 cell entry in vitro and in viv
Externí odkaz:
https://doaj.org/article/b805e181bd2d4dafb2de5ce5eb516da8
Autor:
Suyang Zhang, Feng Yang, Yile Huang, Liangqiang He, Yuying Li, Yi Ching Esther Wan, Yingzhe Ding, Kui Ming Chan, Ting Xie, Hao Sun, Huating Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f33a12df8ea74dbb95dccb3d16948259
Autor:
Hao Huang, Jianyang Hu, Alishba Maryam, Qinghua Huang, Yuchen Zhang, Saravanan Ramakrishnan, Jingyu Li, Haiying Ma, Victor W. S. Ma, Wah Cheuk, Grace Y. K. So, Wei Wang, William C. S. Cho, Liang Zhang, Kui Ming Chan, Xin Wang, Y. Rebecca Chin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhan
Externí odkaz:
https://doaj.org/article/abbe2a31ae264afda36fe681ddcc9d63
Autor:
Yi Ching Esther Wan, Kui Ming Chan
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 694 (2021)
Oncohistones have emerged as a new area in cancer epigenetics research. Recent efforts to catalogue histone mutations in cancer patients have revealed thousands of histone mutations across different types of cancer. In contrast to previously identifi
Externí odkaz:
https://doaj.org/article/1361c4afd25a400fad051929ddb2cad2
Autor:
Congcong Tian, Qin Zhang, Jing Jia, Jiaqi Zhou, Ziwei Zhang, Karri, Srinivasu, Jiuhang Jiang, Dickinson, Quinn, Yuan Yao, Xiaorong Tang, Yuxin Huang, Ting Guo, Ziwei He, Zheng Liu, Yuan Gao, Xinran Yang, Yuchun Wu, Kui Ming Chan, Daoqin Zhang, Junhong Han
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/14/2024, Vol. 121 Issue 20, p1-9, 21p