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Akademický článek

Compound K Inhibits the Lipopolysaccharide-Induced Inflammatory Responses in Raw 264.7 Cell Line and Zebrafish

Autor: Su-Jung Ryu, Jia Choi, Jong-Seok Lee, Hyeon-Son Choi, Kye-Yoon Yoon, Ji-Hyun Hwang, Kui Jin Kim, Boo-Yong Lee

Publikováno v: Applied Sciences, Vol 8, Iss 6, p 924 (2018)

Compound K, a major metabolite of ginsenosides Rb1, which is produced by human intestinal bacteria after oral administration, is one of the main pharmacologic compounds found in ginseng. In our previous study, we demonstrated that compound K inhibite

Externí odkaz: https://doaj.org/article/a6ce690cc1bf48598bb589a14aac8ed5

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Akademický článek

Amphiregulin can predict treatment resistance to palliative first-line cetuximab plus FOLFIRI chemotherapy in patients with RAS wild-type metastatic colorectal cancer

Autor: Sang-A Kim, Hyejoo Park, Kui-Jin Kim, Ji-Won Kim, Ji Hea Sung, Milang Nam, Ju Hyun Lee, Eun Hee Jung, Koung Jin Suh, Ji Yun Lee, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Soo-Mee Bang, Jong Seok Lee, Keun-Wook Lee

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Amphiregulin (AREG) is an epidermal growth factor receptor (EGFR) ligand. The aim of this study was to investigate the effects of baseline plasma AREG levels in KRAS, NRAS, and BRAF wild-type metastatic colorectal cancer (CRC) on treatment o

Externí odkaz: https://doaj.org/article/78fb6769b6784b89bb444f73b016e018

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Akademický článek

Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

Publikováno v: eLife, Vol 11 (2022)

We aimed to elucidate the evolutionary trajectories of gallbladder adenocarcinoma (GBAC) using multi-regional and longitudinal tumor samples. Using whole-exome sequencing data, we constructed phylogenetic trees in each patient and analyzed mutational

Externí odkaz: https://doaj.org/article/eb1e776b7b494318b86d6c03670cbe69

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Akademický článek

Correlation between tumor infiltrating immune cells and peripheral regulatory T cell determined using methylation analyses and its prognostic significance in resected gastric cancer.

Autor: Koung Jin Suh, Jin Won Kim, Ji Eun Kim, Ji Hea Sung, Jiwon Koh, Kui-Jin Kim, Ji-Won Kim, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee, Keun-Wook Lee

Publikováno v: PLoS ONE, Vol 16, Iss 6, p e0252480 (2021)

Peripheral regulatory T cells (pTregs) are a highly immunosuppressive fraction of CD4+ T cells. We aimed to evaluate the clinical significance of pTregs in patients with gastric cancer and to determine the correlation between pTregs and immune cell i

Externí odkaz: https://doaj.org/article/266f83bb9f9447f880ad40ec72104bea

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Akademický článek

Pterostilbene activates the GRP78–elF2α–ATF3 cascade of ER stress and subsequently induces apoptosis in human colon cancer cells

Autor: Kui-Jin Kim, Sungwoo Chei, Seo-Yun Choi, Ok-Hwan Lee, Boo-Yong Lee

Publikováno v: Journal of Functional Foods, Vol 26, Iss , Pp 539-547 (2016)

Pterostilbene (Ptero), a major active compound of blue berries, is a natural antioxidant phytochemical which has a strong potential for cancer prevention and intervention. However, it has not been shown the detailed anti-cancer mechanism of action fo

Externí odkaz: https://doaj.org/article/5adaf6b590f34140a07cee32f5dff064

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Cetuximab resistance induced by hepatocyte growth factor is overcome by MET inhibition in KRAS, NRAS, and BRAF wild-type colorectal cancers

Autor: Kui-Jin Kim, Soo Mee Bang, Yu Jung Kim, Milang Nam, Ji Won Kim, Jin Won Kim, Ji Hea Sung, Ju Hyun Lee, Hyejoo Park, Jee Hyun Kim, Koung Jin Suh, Sang-A Kim, Eun Hee Jung, Ji Yun Lee, Jong Seok Lee, Keun-Wook Lee, Jeong Ok Lee, Se Hyun Kim

Publikováno v: Journal of Cancer Research and Clinical Oncology. 148:2995-3005

PURPOSE Recent evidence has highlighted the role of hepatocyte growth factor (HGF) as a putative biomarker to predict EGFR inhibitor resistance. This study investigated the impact of plasma HGF levels on EGFR inhibition and the counter effect of MET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70a62d8a3145d10f53940b1ad0da76f
https://doi.org/10.1007/s00432-021-03872-4

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Author response: Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e605c2a3f00abfbf86f950881976f6
https://doi.org/10.7554/elife.78636.sa2

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Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling

Autor: Sungwoo Chei, Young-Jin Seo, Kippeum Lee, Boo-Yong Lee, Hyun-Ji Oh, Ji-Hyeon Song, Kui-Jin Kim

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

The blue-green alga Spirulina maxima is a microscopic filamentous cyanobacterium. Spirulina was recently reported to elicit beneficial effects such as reducing cholesterol and inducing weight loss; however, its effects on inflammation are unknown. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c463798c9f72695098b1432b4bdb9ae
http://link.springer.com/article/10.1038/s41598-020-58896-6

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