Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia.

Autor: Kuhrt LD; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Technology Platform Pluripotent Stem Cells, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité - Universitätsmedizin Berlin, Berlin, Germany., Motta E; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Department of Neurosurgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany., Elmadany N; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; German Cancer Consortium (DKTK), Clinical Cooperation Unit (CCU), Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Neurology, Medical Faculty Mannheim (MCTN), University of Heidelberg, 68167 Mannheim, Germany., Weidling H; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité - Universitätsmedizin Berlin, Berlin, Germany., Fritsche-Guenther R; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, BIH Metabolomics Platform, 13353 Berlin, Germany., Efe IE; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité - Universitätsmedizin Berlin, Berlin, Germany., Cobb O; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Chatterjee J; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Boggs LG; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Schnauß M; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Diecke S; Technology Platform Pluripotent Stem Cells, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Semtner M; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, 13353 Berlin, Germany., Anastasaki C; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Gutmann DH; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Kettenmann H; Cellular Neurosciences, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 518000.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2023 Dec 01; Vol. 16 (12). Date of Electronic Publication: 2023 Dec 11.

Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance.

Autor: Holle J; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Bartolomaeus H; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Löber U; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Behrens F; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Institute of Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bartolomaeus TUP; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Anandakumar H; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Wimmer MI; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany., Vu DL; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Core Unit Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Kuhring M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Core Unit Bioinformatics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Brüning U; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Core Unit Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Maifeld A; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany., Geisberger S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; The Berlin Institute for Medical Systems Biology, Berlin, Germany., Kempa S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; The Berlin Institute for Medical Systems Biology, Berlin, Germany., Schumacher F; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany., Kleuser B; Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany., Bufler P; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany., Querfeld U; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany., Kitschke S; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany., Engler D; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany., Kuhrt LD; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Drechsel O; MF1 Bioinformatics, Robert Koch Institute, Berlin, Germany., Eckardt KU; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Forslund SK; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; European Molecular Biology Laboratory, Heidelberg, Germany., Thürmer A; MF2 Genome Sequencing, Robert Koch Institute, Berlin, Germany., McParland V; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Kirwan JA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Core Unit Metabolomics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Wilck N; Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany., Müller D; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2022 Dec; Vol. 33 (12), pp. 2259-2275. Date of Electronic Publication: 2022 Aug 19.

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.

Autor: Ifuku M; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Hinkelmann L; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Kuhrt LD; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Efe IE; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Kumbol V; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Buonfiglioli A; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Krüger C; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Jordan P; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Fulde M; Institute of Microbiology and Epizootics, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany., Noda M; Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan., Kettenmann H; Cellular Neuroscience, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Lehnardt S; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. seija.lehnardt@charite.de.; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. seija.lehnardt@charite.de.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Sep 10; Vol. 8 (1), pp. 159. Date of Electronic Publication: 2020 Sep 10.