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pro vyhledávání: '"Kug Hwa Lee"'
Publikováno v:
Oncotarget
Scaffold proteins of the mitogen activated protein kinase (MAPK) pathway recruit protein kinase cascades to confer context-specificity to cellular signaling. Varying concentrations of scaffold proteins determine different aspects of signaling outputs
Publikováno v:
Cancer Research. 81:1454-1454
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that serves as a key mediator in response to integrin and growth factor signaling to control multiple aspects of cellular behavior. High expression and/or aberrant activation of FAK is obse
Autor:
Sungpyo Hong, Kwangwoo Hwang, Hyoung Min Cho, Soon Kil Ahn, Min-Hyo Ki, Kug Hwa Lee, Yongbin Park
Publikováno v:
Cancer Research. 80:4212-4212
Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer, classified by a lack of ER and PR, and HER2 overexpression. Attributable to its tumor heterogeneity and a high rate of relapse, TNBC carries poor prognosis accounting
Autor:
Kang Yell Choi, Kug Hwa Lee, Young Mi Lee, Jong Chan Park, Saluja Kaduwal, Yong Beom Lim, Do Sik Min, Woo Jeong Jeong, Soung Hoo Jeon
Publikováno v:
Oncotarget
Sur8 (also known as Shoc2) is a Ras-Raf scaffold protein that modulates signaling through extracellular signal-regulated kinase (ERK) pathway. Although Sur8 has been shown to be a scaffold protein of the Ras-ERK pathway, its interaction with other si
Publikováno v:
Experimental & Molecular Medicine
Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC
Publikováno v:
Cancer Research. 75:2330-2330
Adenomatous polyposis coli (APC) loss-of-function mutations and K-Ras gain-of-function mutations are common abnormalities that occur during the initiation and intermediate adenoma stages of colorectal tumorigenesis, respectively. However, little is k