Doxycycline alters inflammatory immune reactions to Plasmodium berghei ANKA and inhibits experimental cerebral malaria in infected C57BL/6 mice

Autor: Kuepper, JM, Schmidt, KE, Schumak, B, Alferink, J, Specht, S, Hoerauf, A

Publikováno v: Infektiologie Update 2018; 26. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20181004-20181006; Wien; DOC18peg27 /20181008/

Malaria is still one of most important infectious diseases despite intensive research and decreasing numbers of fatalities. Among the various outcomes caused by different Plasmodium strains, cerebral malaria (CM) caused by Plasmodium falciparum is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714814baa6425571006123e80b3a08eb

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators.

Autor: Schmidt KE; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Kuepper JM; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Schumak B; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Alferink J; Department of Psychiatry and Psychotherapy, University Hospital Muenster, Muenster, Germany., Hofmann A; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Howland SW; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Rénia L; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Limmer A; Clinic for Anaesthesiology and Intensive Care, University Hospital Essen, Essen, Germany.; Institutes of Molecular Medicine and Experimental Immunology, University Hospital Bonn, Bonn, Germany., Specht S; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany., Hoerauf A; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Publikováno v: PloS one [PLoS One] 2018 Feb 13; Vol. 13 (2), pp. e0192717. Date of Electronic Publication: 2018 Feb 13 (Print Publication: 2018).

Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism.

Autor: Alferink J; From the Institute of Molecular Psychiatry, Medical Faculty, and the Department of Psychiatry, University of Münster, 48149 Münster, Germany, the Cluster of Excellence EXC 1003, Cells in Motion, 48149 Münster, Germany, Judith.alferink@ukmuenster.de., Specht S; the Institute of Medical Microbiology, Immunology, and Parasitology and., Arends H; From the Institute of Molecular Psychiatry, Medical Faculty, and., Schumak B; the Institute of Medical Microbiology, Immunology, and Parasitology and., Schmidt K; the Institute of Medical Microbiology, Immunology, and Parasitology and., Ruland C; the Department of Psychiatry, University of Münster, 48149 Münster, Germany., Lundt R; From the Institute of Molecular Psychiatry, Medical Faculty, and., Kemter A; From the Institute of Molecular Psychiatry, Medical Faculty, and., Dlugos A; the Department of Psychiatry, University of Münster, 48149 Münster, Germany., Kuepper JM; the Institute of Medical Microbiology, Immunology, and Parasitology and., Poppensieker K; From the Institute of Molecular Psychiatry, Medical Faculty, and., Findeiss M; From the Institute of Molecular Psychiatry, Medical Faculty, and., Albayram Ö; From the Institute of Molecular Psychiatry, Medical Faculty, and., Otte DM; From the Institute of Molecular Psychiatry, Medical Faculty, and., Marazzi J; the Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland, and., Gertsch J; the Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland, and., Förster I; the Department of Immunology and Environment, Life and Medical Sciences Institute (LIMES), University of Bonn, 53127 Bonn, Germany., Maier W; the Department of Psychiatry, University Hospital Bonn, 53105 Bonn, Germany., Scheu S; the Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, 40225 Düsseldorf, Germany., Hoerauf A; the Institute of Medical Microbiology, Immunology, and Parasitology and., Zimmer A; From the Institute of Molecular Psychiatry, Medical Faculty, and neuro@uni-bonn.de.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Sep 09; Vol. 291 (37), pp. 19517-31. Date of Electronic Publication: 2016 Jul 29.