A multilineage screen identifies actionable synthetic lethal interactions in human cancers.

Autor: Fong SH; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Kuenzi BM; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Mattson NM; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Lee J; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Sanchez K; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Bojorquez-Gomez A; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Ford K; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Munson BP; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Licon K; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Bergendahl S; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Shen JP; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Kreisberg JF; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Mali P; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA., Hager JH; IDEAYA Biosciences, San Francisco, CA, USA., White MA; IDEAYA Biosciences, San Francisco, CA, USA., Ideker T; Division of Human Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA. tideker@ucsd.edu.; Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. tideker@ucsd.edu.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA. tideker@ucsd.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.

IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells.

Autor: Remsing Rix LL; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA., Sumi NJ; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33620, USA., Hu Q; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33620, USA., Desai B; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33620, USA., Bryant AT; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA., Li X; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA., Welsh EA; Biostatistics and Bioinformatics Shared Resource, Moffitt Cancer Center, Tampa, FL 33612, USA., Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Kinose F; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Kuenzi BM; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33620, USA., Chen YA; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612, USA.; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA., Antonia SJ; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Lovly CM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Koomen JM; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA.; Department of Molecular Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA., Haura EB; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Marusyk A; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA.; Department of Cancer Physiology, Moffitt Cancer Center, Tampa, FL 33612, USA., Rix U; Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL 33612, USA.; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA.

Publikováno v: Science signaling [Sci Signal] 2022 Aug 16; Vol. 15 (747), pp. eabj5879. Date of Electronic Publication: 2022 Aug 16.

Targeting mRNA-coding genes in prostate cancer using CRISPR/Cas9 technology with a special focus on androgen receptor signaling.

Autor: Tabibian, Mobina¹ (AUTHOR), Moghaddam, Fahimeh Salasar² (AUTHOR), Motevaseli, Elahe³ (AUTHOR) e_motevaseli@tums.ac.ir, Ghafouri-Fard, Soudeh² (AUTHOR) s.ghafourifard@sbmu.ac.ir

Publikováno v: Cell Communication & Signaling. 10/17/2024, Vol. 22 Issue 1, p1-20. 20p.

TME-NET: an interpretable deep neural network for predicting pan-cancer immune checkpoint inhibitor responses.

Autor: Ding, Xiaobao^1,2,3 (AUTHOR), Zhang, Lin¹ (AUTHOR), Fan, Ming¹ (AUTHOR) lilh@hdu.edu.cn, Li, Lihua^1,3 (AUTHOR) lilh@hdu.edu.cn

Publikováno v: Briefings in Bioinformatics. Sep2024, Vol. 25 Issue 5, p1-13. 13p.

BioM2: biologically informed multi-stage machine learning for phenotype prediction using omics data.

Autor: Zhang, Shunjie¹ (AUTHOR), Li, Pan² (AUTHOR), Wang, Shenghan² (AUTHOR), Zhu, Jijun² (AUTHOR), Huang, Zhongting² (AUTHOR), Cai, Fuqiang¹ (AUTHOR), Freidel, Sebastian^3,4 (AUTHOR), Ling, Fei¹ (AUTHOR), Schwarz, Emanuel^3,4 (AUTHOR), Chen, Junfang^2,5 (AUTHOR) junfang_chen@fudan.edu.cn

Publikováno v: Briefings in Bioinformatics. Sep2024, Vol. 25 Issue 5, p1-13. 13p.