Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kuei-Jung Yen"'
Autor:
Chi-Shuan Fan, Hui-Chen Hung, Chia-Chi Chen, Li-Li Chen, Yi-Yu Ke, Teng-Kuang Yeh, Chin-Ting Huang, Teng-Yuan Chang, Kuei-Jung Yen, Chung-Hsing Chen, Kee Voon Chua, John Tsu-An Hsu, Tze-Sing Huang
Publikováno v:
Cells, Vol 13, Iss 13, p 1146 (2024)
Extracellular HSP90α (eHSP90α) is a promoter of tumor development and malignant progression. Patients with malignancies, including pancreatic ductal adenocarcinoma (PDAC), have generally shown 5~10-fold increases in serum/plasma eHSP90α levels. In
Externí odkaz:
https://doaj.org/article/7f1e6fbce9c44310ab86b1c52d5b666f
Autor:
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83160 (2014)
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w
Externí odkaz:
https://doaj.org/article/e5078208d61149adbf9f92f8697b3132
Autor:
Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo
Publikováno v:
Journal of Medicinal Chemistry. 62:11135-11150
Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60499fc4136ddd2d5cf080a65b7dda3b
https://doi.org/10.1021/acs.jmedchem.9b01229
https://doi.org/10.1021/acs.jmedchem.9b01229
Autor:
Tzu Ting Peng, Szu Huei Wu, Shin-Ru Shih, Teng Yuan Chang, John Tsu An Hsu, Peng Nien Huang, Shiow Ju Lee, Sheng-Yu Huang, Yi Yu Ke, Wang Chou Sung, Kuei Jung Yen, Chiung-Tong Chen, Hui Chen Hung, Ya Ru Tsai, Shao En Chang, Jiunn Horng Lin, Chin Ting Huang, Yu An Kung, Bing Sin Liu
Publikováno v:
Antimicrobial Agents and Chemotherapy
The coronavirus (CoV) disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a health threat worldwide. Viral main protease (Mpro, also called 3C‐like protease [3CLpro]) is a therapeutic target for drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ca52cf0059ee30df190beea13f3e22
http://europepmc.org/articles/PMC7449189
http://europepmc.org/articles/PMC7449189
Autor:
Wen Chieh Wang, Yun I. Chang, Fu Ming Kuo, Po Chu Kuo, Ching Ping Chen, Chiung-Tong Chen, Jen Shin Song, Mohane Selvaraj Coumar, Ching Chuan Kuo, Chun Wei Chang, An Siou Li, Ming Hsine Wu, Yi Yu Ke, Teng Kuang Yeh, Sing Yi Wang, Hui Yi Shiao, Kuei Jung Yen, Yung Chang Hsu, Chun Hwa Chen, Wen-Hsing Lin, Hsing Pang Hsieh, John T.A. Hsu, Pei Yi Chen, Chen Lung Huang, Chuan Shih
Publikováno v:
Oncotarget
// Yung Chang Hsu 1, * , Mohane Selvaraj Coumar 2, * , Wen-Chieh Wang 1, * , Hui-Yi Shiao 1, * , Yi-Yu Ke 1 , Wen-Hsing Lin 1 , Ching-Chuan Kuo 1 , Chun-Wei Chang 1 , Fu-Ming Kuo 1 , Pei-Yi Chen 1 , Sing-Yi Wang 1 , An-Siou Li 1 , Chun-Hwa Chen 1 , P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a2eb341741edb83e6b9a1de9e85c4
https://doi.org/10.18632/oncotarget.13369
https://doi.org/10.18632/oncotarget.13369
Autor:
Kuei Jung Yen, Tsu Hsu, Ling Hui Chou, Yu Ling Huang, Yu-Sheng Chao, H. Eugene Liu, Cheng Tai Lu, Teng Kuang Yeh, Weir-Torn Jiaang, Jen Shin Song, Chun Hwa Chen, Po Chu Kuo, Ching Ping Chen, Shih Chieh Yen, Chiung-Tong Chen, Wen-Hsing Lin, Chen Lung Huang, John T.A. Hsu
Publikováno v:
European Journal of Medicinal Chemistry. 100:151-161
Numerous FLT3 inhibitors have been explored as a viable therapy for the treatment of acute myeloid leukemia (AML). However, clinical data have been underwhelming due to incomplete inhibition of FLT3 or the emergence of resistant mutations treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b23817984e4202f9b481b6ab6ca61f
https://doi.org/10.1016/j.ejmech.2015.05.008
https://doi.org/10.1016/j.ejmech.2015.05.008
Autor:
Chungming Chang, Yung Chang Hsu, John T.A. Hsu, Yi Yu Ke, Kuei Jung Yen, Chun Hwa Chen, Hsing Pang Hsieh, Wen-Hsing Lin, Chieh Chien Lee, Hui Yi Shiao
Publikováno v:
ChemMedChem. 9:953-961
Computer-guided drug design is a powerful tool for drug discovery. Herein we disclose the use of this approach for the discovery of dual FMS-like receptor tyrosine kinase-3 (FLT3)-Aurora A inhibitors against cancer. An Aurora hit compound was selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6549b7977ebce8d445b608e5872bbe1
https://doi.org/10.1002/cmdc.201300571
https://doi.org/10.1002/cmdc.201300571
Autor:
Yung-Ning Yang, Wen-Hsing Lin, Ching-Ping Chen, Tsu Hsu, John T.A. Hsu, Weir-Torn Jiaang, Yu-Sheng Chao, Ching-Fang Yeh, Ling-Hui Chou, Chun-Hwa Chen, Teng-Kuang Yeh, Jen-Shin Song, Chiung-Tong Chen, Shu-Yi Hsieh, Cheng-Tai Lu, Ching-Hui Chiu, Shih-Chieh Yen, Ya-Ju Tseng, Kuei-Jung Yen
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2856-2867
Preclinical investigations and early clinical trials suggest that FLT3 inhibitors are a viable therapy for acute myeloid leukemia. However, early clinical data have been underwhelming due to incomplete inhibition of FLT3. We have developed 3-phenyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40789ec034aee7931573505d93f593c
https://doi.org/10.1016/j.bmc.2013.03.083
https://doi.org/10.1016/j.bmc.2013.03.083
Autor:
Huan-Chih Chiu, Wen-Hsing Lin, Tzu-Wen Lien, John T.A. Hsu, Ding-Li Chou, Kuei-Jung Yen, Chin-Ting Huang
Publikováno v:
Biochemical Pharmacology. 81:1263-1270
Epidermal growth factor receptor (EGFR) is a proven therapeutic target to treat a small subset of non small cell lung cancer (NSCLC) harboring activating mutations within the EGFR gene. However, many NSCLC patients are not sensitive to EGFR inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab72c7973a887d1388670c07070f2b5
https://doi.org/10.1016/j.bcp.2011.03.003
https://doi.org/10.1016/j.bcp.2011.03.003
Autor:
John T.A. Hsu, Ming-Yu Fang, Kuei-Jung Yen, Tzu-Chun Chen, Shin-Ru Shih, Ching-Ping Tseng, Hui-Chen Hung
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. Methods To measure the activity of ATA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e615f0ebf21a3d7f75ce8a05c5a2ba4
http://europepmc.org/articles/PMC7110181
http://europepmc.org/articles/PMC7110181