NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.

Autor: Sun C; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Seranova E; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Cohen MA; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Chipara M; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Roberts J; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Astuti D; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Palhegyi AM; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Acharjee A; Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK; Institute of Translational Medicine, University Hospitals Birmingham, NHS Foundation Trust, Birmingham B15 2TT, UK; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham B15 2WB, UK., Sedlackova L; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Kataura T; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Otten EG; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Panda PK; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Lara-Reyna S; Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK., Korsgen ME; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Kauffman KJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Huerta-Uribe A; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Zatyka M; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Silva LFSE; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Torresi J; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Zhang S; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Hughes GW; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Ward C; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Kuechler ER; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Cartwright D; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Trushin S; Department of Neurology, Mayo Clinic, Rochester, MN 55901, USA., Trushina E; Department of Neurology, Mayo Clinic, Rochester, MN 55901, USA., Sahay G; Department of Pharmaceutical Sciences and Department of Biomedical Engineering, College of Pharmacy, Oregon State University, Portland, OR 97201, USA., Buganim Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Lavery GG; Department for Biosciences, Nottingham Trent University, Nottingham NG11 8NS, UK., Gsponer J; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Anderson DG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard and MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Frickel EM; Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK., Rosenstock TR; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Barrett T; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; Department of Endocrinology, Birmingham Women's and Children's Hospital, Steelehouse Lane, Birmingham B4 6NH, UK., Maddocks ODK; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Tennant DA; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Wang H; The State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China., Jaenisch R; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Korolchuk VI; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address: viktor.korolchuk@newcastle.ac.uk., Sarkar S; Institute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: s.sarkar@bham.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 May 30; Vol. 42 (5), pp. 112372. Date of Electronic Publication: 2023 Apr 21.

Pulse labeling reveals the tail end of protein folding by proteome profiling.

Autor: Zhu M; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Kuechler ER; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Wong RWK; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Calabrese G; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Sitarik IM; Department of Chemistry, Penn State University, Pennsylvania, PA 16802, USA., Rana V; Department of Chemistry, Penn State University, Pennsylvania, PA 16802, USA., Stoynov N; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., O'Brien EP; Department of Chemistry, Penn State University, Pennsylvania, PA 16802, USA., Gsponer J; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Mayor T; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: mayor@msl.ubc.ca.

Publikováno v: Cell reports [Cell Rep] 2022 Jul 19; Vol. 40 (3), pp. 111096.

Protein feature analysis of heat shock induced ubiquitination sites reveals preferential modification site localization.

Autor: Kuechler ER; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Rose A; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Bolten M; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Madero A; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Kammoonah S; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Colborne S; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 W. 10th Ave, Vancouver V5Z 1L3, Canada., Gsponer J; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada., Morin GB; Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 W. 10th Ave, Vancouver V5Z 1L3, Canada; Department of Medical Genetics, University of British Columbia, 4500 Oak St, Vancouver V6H 3N1, Canada., Mayor T; Department of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, 2125 East Mall, Vancouver V5T 1Z4, Canada. Electronic address: mayor@msl.ubc.ca.

Publikováno v: Journal of proteomics [J Proteomics] 2021 May 15; Vol. 239, pp. 104182. Date of Electronic Publication: 2021 Mar 09.

Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae .

Autor: Zhu M; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4., Kuechler ER; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4., Zhang J; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4., Matalon O; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Dubreuil B; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Hofmann A; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3., Loewen C; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3., Levy ED; Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel., Gsponer J; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4., Mayor T; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4 mayor@msl.ubc.ca.

Publikováno v: Journal of cell science [J Cell Sci] 2020 Jul 09; Vol. 133 (13). Date of Electronic Publication: 2020 Jul 09.

VR-SCOSMO: A smooth conductor-like screening model with charge-dependent radii for modeling chemical reactions.

Autor: Kuechler ER; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854-8087, USA., Giese TJ; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854-8087, USA., York DM; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854-8087, USA.

Publikováno v: The Journal of chemical physics [J Chem Phys] 2016 Apr 28; Vol. 144 (16), pp. 164115.