Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

Autor: Wiviott S. D., Raz I., Bonaca M. P., Mosenzon O., Kato E. T., Cahn A., Silverman M. G., Zelniker T. A., Kuder J. F., Murphy S. A., Bhatt D. L., Leiter L. A., McGuire D. K., Wilding J. P. H., Ruff C. T., Nilsson G. I., Fredriksson M., Johansson P. A., Langkilde A. M., Sabatine M. S., Bansilal S., Furtado R., Fish M. P., Gabovitch D., Jevne A., Ahern S., Im K., Goodrich E. L., Lowe C., Fisher N., Gannon J., Trindade S., Towarowski A., Fox Y., Johnsson E., Ranft S., Faber B., Wallander M., Weiss A., Buskila A., Abola M. T. B., Ardissino D., Averkov O., Aylward P., Bode C., Bonnici F., Bonora E., Budaj A. J., Cernea S., Chiang C. E., Cooper M., Dalby A., Deerochanawong C., Dellborg M., Diaz R., Dimulescu D., Eliaschewitz F. G., Goudev A. R., Hadjadj S., Herrera M., Huo Y., Jermendy G., Ji L., Kadowaki T., Kiss R., Kooy A., Kumar K. M. P., Lewis B., Litwak L., Lopez-Sendon J., Ma R., Merlini P. A., Nauck M. A., Nguyen T. K., Nicolau J. C., Ostgren C. J., Ophuis T. O., Padilla F., Pais P., Park K. S., Parkhomenko A., Ray K., Rosenstock J., Ruda M., Satman I., Shestakova M., Smahelova A., Spinar J., Strojek K., Sy R., Tankova T., Theroux P., Tkac I., Van Gaal L., Wainstein J., Harrington R. A., Droller M. J., Lee K. L., Nesto R. W., Tuomilehto J., Hedlin H., Desai M., Sayfer I., Alexanian S., Awtry E., Bentley-Lewis R., Berger C. J., Croce K., Desai A., Garg R. K., Gelfand E., Gignac G., Goessling W., Ho C., Hochberg E., Lane A., Larrey D., Leeman D. E., Lewis J., Link M. S., McDonnell M. E., Norden A. D., Pande A., Rosenberg C., Rost N., Ruberg F., Schiff E., Silverman S., Singhal A., Wagner A., Wolpin B., Aizenberg D., Fernandez M., Sala J., Maffei L., Luquez C., Waitman J., Rista L., Nardone L., Sposetti G., Cantero M., Alvarisqueta A., Montana O., Cuadrado J., Cartasegna L., Baccaro C., Chertkoff A., Sanabria H., Vainstein N., Amerena J., Arya K., d'Emden M., Proietto J., Moses R., Colquhoun D., Stranks S., Lehman R., Hamilton A., Whelan A., Simpson R., Purnell P., Abhayaratna W., Hammett C., McKeirnan M., Sullivan D., Bach L., Hughes K., Mathieu C., Vercammen C., Scheen A., Duyck F., Cools F., De Wolf L., Verhaegen A., Nobels F., Missault L., Crenier L., Thoeng J., Wollaert B., Vandenbroucke M., Eliaschewitz F., Borges J. L. C., Turatti L., Lima F. G., dos Santos F., Kerr Saraiva J., Pereira M., Pereira A., Precoma D. B., Filho G. F. V., Reis G., Maia L. N., Bacheva T., Temelkova-Kurktschiev T., Maneva S., Stoyanovska B., Boshnyashka R., Stoykova Y., Georgiev D., Tagarev Z., Dimitrova E., Vitkina M., Yordanova L., Temelkova M., Vasileva S., Kuneva T., Zyumbyuleva M., Daskalova I., Genadieva V., Boyanov L., Farah G., Lazarova G., Georgieva M., Krasteva S., Slavcheva A., Yabroudi N., Veleva N., Zlateva A., Damyanova V., Elenkova A., Kotselova T., Genov K., Lyubenova L., Temelkova N., Harizanova B., Zaharieva S., Bajaj H., Goldenberg R., Aronson R., Twum-Barima D., Dumas R., Kouz S., Kaiser S. M., Ajala B., Cha J., Teitelbaum I., Chouinard G., Woo V., Dan Dattani I., Mazza G., Gaudet D., Poirier P., Conway J., Dion D., McKeough M., Manyari D., Harris S., St-Pierre B., Yale J. F., Landry D., Gupta M., Hramiak I., Lau D., DeGrace M., Gallo R., Montigny M., Dzongowski P., Liutkus J., Frechette A., Gosselin G., Sabbah E., Langlois M. F., Rabasa-Lhoret R., Bedard J., Hart R., Dowell A., Pandey A., O'Keefe D., Hill L., Weisnagel S. J., Muirhead N., Zimmermann R., Galiwango P., Tobe S., Priestman B., Zinman B., Ma J., Zhao X., Wang C., Zhang A., Dong Y., Dong X., Luo M., Guo J., Zheng Z., Li Y., Liang Y., Peng D., Maderic D., Spinarova L., Raclavska L., Ludka O., Rihacek I., Karasova J., Pelikanova M., Vlasakova H., Urbancova K., Zamrazil V., Hradec J., Vlasicova H., Racicka E., Okenka L., Naplava R., Skopecek J., Palova S., Krystl T., Pistek Z., Oznerova M., Andresova A., Sarbochova R., Taborska P., Petrova I., Stanek L., Reichert P., Lorenc Z., Szabo M., Petit C., Krempf M., Boye A., Dubois S., Clavel S., Gourdy P., Elbaz M., Jazayeri S., Gouet D., Verges B., Couffinhal T., Sendeski M., Klausmann G., Appel K., Pein M., Thieme R., Schumm-Draeger P., Jacob S., Toursarkissian N., Kleinecke-Pohl U., Tschope D., Ott P., Haak T., Nauck M., Derwahl K., Bugger H., Hui G., Tsang C., Zilahi Z., Puski L., Vangel S., Fulop T., Pall K., Hidvegi T., Revesz K., Koranyi L., Kajetan M., Kerenyi Z., Penzes J., Herczeg B., Laszloczky A., Turi T., Rapi J., Pentek Z., Gaal Z., Winkler G., Percs E., Czigany A., Harcsa E., Gurzo M., Tassaly J., Horthy R., Petro G., Farago K., Muller G., Varju I., Kirschner R., Kiss I., Bakai J., Kancz S., Marton Z., Kodur R., Yajnik C., Thomas N., Ayyar V., Iyengar P., Bashkin A., Daoud D., Itzhak B., Katz A., Tsur A., Nikolsky E., Atar S., Grossman A., Klainman E., Tsalihin D., Shotan A., Turgeman Y., Ferrario M., Merlini P., Piatti P., Zenari L., Trevisan R., Bosco B., Di Lorenzo L., Mannucci E., Avogaro A., Reimers B., Trimarco B., Silvestri O., Salvioni A., Nakagawa H., Sueyoshi A., Fukuda K., Yasumoto H., Matsubayashi S., Kawajiri K., Togashi Y., Senokuchi T., Ohta Y., Yamauchi T., Node K., Alcocer Gamba M., Herrera Marmolejo M., De los Rios Ibarra M., Gonzalez Galvez G., Garcia Cantu E., Leguizamo Dimas A., Luna Ceballos R., Medina Pech C., Stobschinski de Alba C., Gonzalez Gonzalez J., Padilla Padilla F., Fanghanel Salmon G., Robles Torres F., Lopez Rosas E., Pelayo Orozco E., Banda Elizondo R., Escalona Caamano A., Frenk Baron P., Aguilar Salinas C., Mustieles Rocha C., Vidrio Velazquez M., Rodriguez Briones I., Saldate Alonso M., Velasco Sanchez R., Groenemeijer B., Ronner E., Kuijper A., Strikwerda S., Van Kempen W., Gijsbers S., Oude Ophuis A., Swart H., Hoogenberg K., Hovens M., van Hessen M., Westerink J., Kragten J., Nierop P., Bax W., Hartong S., Nieuwdorp M., Gonkel F., Al Windy N., Troquay R., Schaafsma H., Lieverse A., Knufman N., Tirador L., Guenon M., Ferrolino A., Atilano A., Aportadera M., Que M., Denopol M., Tolentino M., Jimeno C., Wee J., Mirasol R., Panelo A., Roxas D., Abola M., Palmes P., Silva A., Salvador D., Rosita R., Maravilla L., Rogelio G., Pacheco E., Tin Hay L., Prado J., Krzyzagorska E., Witek R., Miklaszewicz B., Sudnik W., Pomiecko W., Bochenek A., Fares I., Wujkowski M., Korol M., Powierza S., Goch A., Miekus P., Siegel A., Skierkowska J., Romanczuk P., Cygler J., Landa K., Szyprowska E., Stachlewski P., Czerski T., Pawlowicz L., Sowinski D., Romanowski L., Rudzki H., Skorski M., Jasiel-Wojculewicz H., Stasiewski A., Budaj A., Kania G., Mirek-Bryniarska E., Wojnowski L., Korzeniak R., Oh T., Park K., Lee M., Lee K., Jang H., Kim S., Ku B., Cha B., Son H., Lee I., Park J., Yu S., Shon H., Rhee E., Cho J., Park T., Nam J., Pintilei E., Popescu A., Nafornita V., Gutu O., Dumitrescu A., Bala C., Caceaune E., Mindrescu N., Morosanu M., Bradescu O., Munteanu M., Voitec M., Vlaiculescu M., Hancu N., Diaconu Sotropa M., Lupu S., Mateescu A., Carlan L., Marton R., Lupusoru D., Mot A., Coman A., Zaharie D., Rebrov A., Shutemova E., Bolieva L., Khalimov Y., Statsenko M., Galyavich A., Koziolova N., Shapovalova Y., Pavlysh E., Strongin L., Vertkin A., Vishneva E., Pavlova M., Khasanov N., Antsiferov M., Gavrisheva I., Sokolova N., Vorobyev S., Morugova T., Sinitsina I., Ezhov A., Kobalava Z., Belenkiy D., Supryadkina T., Kazakov Y., Oschepkova E., Dreval A., Novikova T., Vishnevsky A., Chizhov D., Akatova 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Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2019, 380 (4), pp.347-357. ⟨10.1056/NEJMoa1812389⟩
NEW ENGLAND JOURNAL OF MEDICINE

BACKGROUND The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is undefined. METHODS We randomly assigned patients with type 2 diabetes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64ebf8d0230d5b1536b57065919a988
https://hal.archives-ouvertes.fr/hal-02543624

Obesity and effects of dapagliflozin on cardiovascular and renal outcomes in patients with type 2 diabetes mellitus in the DECLARE-TIMI 58 trial.

Autor: Oyama K; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA.; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan., Raz I; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Kiryat Hadassah 12000, Jerusalem 91200, Israel., Cahn A; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Kiryat Hadassah 12000, Jerusalem 91200, Israel., Kuder J; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA., Murphy SA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA., Bhatt DL; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA., Leiter LA; Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 36 Queen St. East, Toronto, ON M5B 1W8, Canada., McGuire DK; Division of Cardiology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, 5323 Harry Hines Blvd. Dallas, TX 75390, USA., Wilding JPH; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, 6 West Derby Street, Liverpool, L7 8TX, UK., Park KS; Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu Seoul 03080, Republic of Korea., Goudev A; Department of Cardiology, Queen Giovanna University Hospital, 8# Bialo More street, Sofia 1527, Bulgaria., Diaz R; Estudios Clínicos Latino America, Paraguay 160, Rosario, Santa Fe 2000, Argentina., Špinar J; Internal Cardiology Department, St. Ann University Hospital, Masaryk University, Pekařská 53 Brno 65691, Czech Republic., Gause-Nilsson IAM; BioPharmaceuticals R&D, AstraZeneca Gothenburg, Pepparedsleden 1, S-431 83, Mölndal, Sweden., Mosenzon O; Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Kiryat Hadassah 12000, Jerusalem 91200, Israel., Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA., Wiviott SD; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Suite 7022, Boston, MA 02115, USA.

Publikováno v: European heart journal [Eur Heart J] 2022 Aug 14; Vol. 43 (31), pp. 2958-2967.

Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex.

Autor: Carnicelli AP; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Hong H; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC.; Department of Biostatistics and Bioinformatics (H.H., K.H.), Duke University, Durham, NC., Connolly SJ; Department of Medicine, McMaster University, Ontario, Canada (S.J.C., J.E.).; Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada (S.J.C., J.E., A.P.B., L.D.)., Eikelboom J; Department of Medicine, McMaster University, Ontario, Canada (S.J.C., J.E.).; Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada (S.J.C., J.E., A.P.B., L.D.)., Giugliano RP; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., D.A.M., E.A.B., J.K., C.T.R.).; Thrombolysis in Myocardial Infarction Study Group, Boston, MA (R.P.G., D.A.M., E.A.B., C.T.R.)., Morrow DA; Thrombolysis in Myocardial Infarction Study Group, Boston, MA (R.P.G., D.A.M., E.A.B., C.T.R.)., Patel MR; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Wallentin L; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Uppsala Clinical Research Center and Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden.; Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden., Alexander JH; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Cecilia Bahit M; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Department of Cardiology, INECO Neurociencias Oroño, Santa Fe, Argentina (M.C.B.)., Benz AP; Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada (S.J.C., J.E., A.P.B., L.D.)., Bohula EA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., D.A.M., E.A.B., J.K., C.T.R.).; Thrombolysis in Myocardial Infarction Study Group, Boston, MA (R.P.G., D.A.M., E.A.B., C.T.R.)., Chao TF; Division of Cardiology, Taipei Veterans General Hospital, Taiwan (T.-F.C.)., Dyal L; Population Health Research Institute, Hamilton Health Sciences, Ontario, Canada (S.J.C., J.E., A.P.B., L.D.)., Ezekowitz M; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Lankenau Institute for Medical Research, Wynnewood, PA (M.E.)., A A Fox K; Center for Cardiovascular Science, University of Edinburgh, Scotland (K.A.A.F.)., Gencer B; Division of Cardiology, Geneva University Hospitals, Geneva, Switzerland (B.G.).; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland (B.G.)., Halperin JL; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; The Cardiovascular Institute, Mount Sinai Medical Center, New York, NY (J.L.H.)., Hijazi Z; Uppsala Clinical Research Center and Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden.; Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden., Hohnloser SH; Department of Cardiology, JW Goethe University, Frankfurt, Germany (S.H.H.)., Hua K; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC.; Department of Biostatistics and Bioinformatics (H.H., K.H.), Duke University, Durham, NC., Hylek E; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Department of Medicine, Boston University School of Medicine, MA (E.H.)., Toda Kato E; Department of Cardiology, Kyoto University, Japan (E.T.K.)., Kuder J; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., D.A.M., E.A.B., J.K., C.T.R.).; Thrombolysis in Myocardial Infarction Study Group, Boston, MA (R.P.G., D.A.M., E.A.B., C.T.R.)., Lopes RD; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Mahaffey KW; Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, CA (K.W.M.)., Oldgren J; Uppsala Clinical Research Center and Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden.; Department of Medical Sciences (L.W., Z.H., J.O.), Uppsala University, Sweden., Piccini JP; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Ruff CT; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.P.G., D.A.M., E.A.B., J.K., C.T.R.).; Thrombolysis in Myocardial Infarction Study Group, Boston, MA (R.P.G., D.A.M., E.A.B., C.T.R.)., Steffel J; Department of Cardiology, University of Zurich, Switzerland (J.S.)., Wojdyla D; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC., Granger CB; Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke University, Durham, NC.; Duke Clinical Research Institute (A.P.C., H.H., M.R.P., J.H.A., K.H., R.D.L., J.P.P., D.W., C.B.G.), Duke University, Durham, NC.

Publikováno v: Circulation [Circulation] 2022 Jan 25; Vol. 145 (4), pp. 242-255. Date of Electronic Publication: 2022 Jan 05.

An integrated study of the NE German Basin

Autor: Bayer, U. ^*, Scheck, M., Rabbel, W., Krawczyk, C.M., Götze, H.-J., Stiller, M., Beilecke, Th., Marotta, A.-M., Barrio-Alvers, L., Kuder, J.

Publikováno v: In Tectonophysics 10 December 1999 314(1-3):285-307

The Efficacy of Andexanet Alfa for the Reversal of Factor Xa Inhibitors Is Not Influenced by Hemodilution with Different Volume Expanders.

Autor: Wienhold, Jan¹ (AUTHOR) jwienhold@ukaachen.de, Rossaint, Rolf¹ (AUTHOR), Vandeput, Eline¹ (AUTHOR), Grottke, Oliver¹ (AUTHOR)

Publikováno v: Journal of Clinical Medicine. Nov2024, Vol. 13 Issue 22, p6706. 12p.