Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation.

Autor: Pham L; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Komalavilas P; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Eddie AM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Thayer TE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Greenwood DL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Liu KH; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA., Weinberg J; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA., Patterson A; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Fessel JP; Division of Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD, USA., Boyd KL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Schafer JC; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Kuck JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shaver AC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Flaherty DK; Flow Cytometry Shared Resource, Vanderbilt University Medical Center, Nashville, TN, USA., Matlock BK; Flow Cytometry Shared Resource, Vanderbilt University Medical Center, Nashville, TN, USA., Wijers CDM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Serezani CH; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jones DP; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA., Brittain EL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rathmell JC; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Noto MJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Michael.james.noto@emory.edu.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Michael.james.noto@emory.edu.

Publikováno v: Communications biology [Commun Biol] 2022 Dec 13; Vol. 5 (1), pp. 1366. Date of Electronic Publication: 2022 Dec 13.

Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.

Autor: Shaver CM; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wickersham N; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., McNeil JB; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Nagata H; Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan., Miller A; Tennessee Donor Services, Nashville, Tennessee, USA., Landstreet SR; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kuck JL; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Diamond JM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lederer DJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University School of Medicine, New York, New York, USA., Kawut SM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Palmer SM; Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA., Wille KM; Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Weinacker A; Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Palo Alto, California, USA., Lama VN; Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA., Crespo MM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Orens JB; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University Medical Center, Baltimore, Maryland, USA., Shah PD; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University Medical Center, Baltimore, Maryland, USA., Hage CA; Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Cantu E 3rd; Division of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Porteous MK; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Dhillon G; Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Palo Alto, California, USA., McDyer J; Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bastarache JA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Christie JD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ware LB; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Publikováno v: JCI insight [JCI Insight] 2018 Jan 25; Vol. 3 (2). Date of Electronic Publication: 2018 Jan 25 (Print Publication: 2018).

Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target.

Autor: Shaver CM; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Wickersham N; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., McNeil JB; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Nagata H; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; 2 Department of Anesthesia, Keio University, Tokyo, Japan., Sills G; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Kuck JL; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Janz DR; 3 Internal Medicine/Pulmonary and Critical Care Medicine, Louisiana State University School of Medicine, New Orleans, Louisiana; and., Bastarache JA; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Ware LB; 1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; 4 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: Annals of the American Thoracic Society [Ann Am Thorac Soc] 2017 Sep; Vol. 14 (Supplement_3), pp. S251-S252.

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs.

Autor: Kuck JL; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama;, Obiako BO; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama;, Gorodnya OM; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama;, Pastukh VM; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama;, Kua J; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama;, Simmons JD; Department of Surgery and Center for Lung Biology, University of South Alabama, College of Medicine, Mobile, Alabama., Gillespie MN; Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama; mgillesp@southalabama.edu.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2015 May 15; Vol. 308 (10), pp. L1078-85. Date of Electronic Publication: 2015 Mar 20.