The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Autor: Kuchnio A; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Moens S; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Bruning U; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Kuchnio K; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Cruys B; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Thienpont B; Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory for Translational Genetics, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Broux M; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Ungureanu AA; Laboratory of Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001 Heverlee, Belgium., Leite de Oliveira R; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Bruyère F; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Cuervo H; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Manderveld A; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Carton A; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Hernandez-Fernaud JR; Laboratory of Vascular Proteomics, Cancer Research UK Beatson Institute, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Zanivan S; Laboratory of Vascular Proteomics, Cancer Research UK Beatson Institute, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Bartic C; Laboratory of Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001 Heverlee, Belgium; IMEC, Kapeldreef 75, 3001 Heverlee, Belgium., Foidart JM; Laboratory of Tumor and Developmental Biology, GIGA-Cancer, University of Liège, Avenue de l'Hôpital 3, 4000 Liège, Belgium., Noel A; Laboratory of Tumor and Developmental Biology, GIGA-Cancer, University of Liège, Avenue de l'Hôpital 3, 4000 Liège, Belgium., Vinckier S; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Lambrechts D; Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory for Translational Genetics, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Dewerchin M; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Mazzone M; Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium., Carmeliet P; Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Herestraat 49, 3000 Leuven, Belgium. Electronic address: peter.carmeliet@vib-kuleuven.be.

Publikováno v: Cell reports [Cell Rep] 2015 Aug 11; Vol. 12 (6), pp. 992-1005. Date of Electronic Publication: 2015 Jul 30.