Insights into gene regulation under temozolomide-promoted cellular dormancy and its connection to stemness

Autor: Kubelt, C, Hellmold, D, Ahmeti, H, Synowitz, M, Held-Feindt, J

Publikováno v: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCP059 /20220525/

Objective: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The aggressive properties of GBM were shown to be linked to distinct phenomena such as stemness and dormancy – a reversible growth arrest of tumor cells p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5675663cad2c3d80b21d4ce521828a75

Establishment of an in vivo adapted in vitro model of deep brain stimulation and investigations regarding the influence of electric stimulation on inflammatory mediators

Autor: Molkewehrum, H, Kubelt, C, Synowitz, M, Held-Feindt, J, Helmers, AK

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCP109 /20200626/

Objective: Deep brain simulation (DBS) is a neurosurgical therapy especially for movement disorders but also psychiatric diseases as depressions with a therapy-refractory course are rising. Even if the therapeutic results are mostly satisfactory, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1079a0579760bae3c13635f7a41bf251

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Case report of recurrent anaplastic oligodendroglioma with mixed astrocytic components and pathological discordance of tumor progression

Autor: Scheer, M., Strauss, C., Scheller, C., Kubelt, C., Skalej, M., Mawrin, C., Prell, J.

Publikováno v: In Interdisciplinary Neurosurgery: Advanced Techniques and Case Management September 2021 25

Analysis of epithelial-to-mesenchymal transition in paired primary and recurrent glioblastomas

Autor: Kubelt, C, Hattermann, K, Sebens, S, Mehdorn, M, Held-Feindt, J

Publikováno v: 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20150607-20150610; Karlsruhe; DOCP 044 /20150602/

Objective: Malignant glioblastomas have a median survival time of less than one year which is mainly due to aggressive relapses after therapeutic treatment. They achieve their progressive character via epithelial-to-mesenchymal transition (EMT); howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04db467d5f4658612e37ad9c9713969b