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Akademický článek

Aronia melanocarpa L. fruit peels show anti-cancer effects in preclinical models of breast carcinoma: The perspectives in the chemoprevention and therapy modulation

Autor: Dana Dvorska, Alena Mazurakova, Lenka Lackova, Dominika Sebova, Karol Kajo, Marek Samec, Dusan Brany, Emil Svajdlenka, Jakub Treml, Sandra Mersakova, Jan Strnadel, Marian Adamkov, Zora Lasabova, Kamil Biringer, Jan Mojzis, Dietrich Büsselberg, Karel Smejkal, Martin Kello, Peter Kubatka

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionWithin oncology research, there is a high effort for new approaches to prevent and treat cancer as a life-threatening disease. Specific plant species that adapt to harsh conditions may possess unique properties that may be utilized in the

Externí odkaz: https://doaj.org/article/712cfb8a7251426ca7c5229d02600bef

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Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine

Autor: Alena Mazurakova, Lenka Koklesova, Sandra Hurta Csizmár, Marek Samec, Aranka Brockmueller, Miroslava Šudomová, Kamil Biringer, Erik Kudela, Martin Pec, Samson Mathews Samuel, Monika Kassayova, Sherif T.S. Hassan, Karel Smejkal, Mehdi Shakibaei, Dietrich Büsselberg, Luciano Saso, Peter Kubatka, Olga Golubnitschaja

Publikováno v: Journal of Advanced Research, Vol 55, Iss , Pp 103-118 (2024)

Background: Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically to maintain their supply of energy and precursor molecules

Externí odkaz: https://doaj.org/article/8d1874c70909462aa7839fd64043bac5

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Akademický článek

Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

Autor: Peter Kubatka, Alena Mazurakova, Lenka Koklesova, Tomas Kuruc, Marek Samec, Karol Kajo, Klaudia Kotorova, Marian Adamkov, Karel Smejkal, Emil Svajdlenka, Dana Dvorska, Dusan Brany, Eva Baranovicova, Vladimira Sadlonova, Jan Mojzis, Martin Kello

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: Based on extensive data from oncology research, the use of phytochemicals or plant-based nutraceuticals is considered an innovative tool for cancer management. This research aimed to analyze the oncostatic properties of Salvia officinal

Externí odkaz: https://doaj.org/article/c3662297b57548de96e5359613f70678

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Akademický článek

Therapy-resistant breast cancer in focus: Clinically relevant mitigation by flavonoids targeting cancer stem cells

Autor: Alena Mazurakova, Lenka Koklesova, Desanka Vybohova, Marek Samec, Erik Kudela, Kamil Biringer, Miroslava Šudomová, Sherif T. S. Hassan, Martin Kello, Dietrich Büsselberg, Olga Golubnitschaja, Peter Kubatka

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Significant limitations of the reactive medical approach in breast cancer management are clearly reflected by alarming statistics recorded worldwide. According to the WHO updates, breast malignancies become the leading cancer type. Further, the porti

Externí odkaz: https://doaj.org/article/ca1d5eb914e6438ba1eb2609781c6715

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Akademický článek

Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Autor: Lenka Koklesova, Jana Jakubikova, Dana Cholujova, Marek Samec, Alena Mazurakova, Miroslava Šudomová, Martin Pec, Sherif T. S. Hassan, Kamil Biringer, Dietrich Büsselberg, Tatiana Hurtova, Olga Golubnitschaja, Peter Kubatka

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading to disease progression and treatment failure. Targeted treatment of heterogeneous population of cells - cancer stem cells is still an issue in protecting aff

Externí odkaz: https://doaj.org/article/acb3eb4df5d04e828d51a0d3755618d1

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Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare

Autor: Holubekova Veronika, Kolkova Zuzana, Kasubova Ivana, Samec Marek, Mazurakova Alena, Koklesova Lenka, Kubatka Peter, Rokos Tomas, Kozubik Erik, Biringer Kamil, Kudela Erik

Publikováno v: Biomolecular Concepts, Vol 13, Iss 1, Pp 61-80 (2022)

One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of

Externí odkaz: https://doaj.org/article/bc1252abb3ae4edf95ca236f1b5a25c9

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Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers

Autor: Raghad Khalid AL-Ishaq, Peter Kubatka, Dietrich Büsselberg

Publikováno v: Nutrients, Vol 15, Iss 17, p 3675 (2023)

Worldwide, the demand for natural and synthetic sweeteners in the food industry as an alternative to refined sugar is increasing. This has prompted more research to be conducted to estimate its safety and effects on health. The gut microbiome is crit

Externí odkaz: https://doaj.org/article/9b614a669528474ab7334b9cfa7f369d

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