Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kuangyu Yen"'
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110409- (2024)
Summary: PU.1 (SPI1) is pivotal in hematopoiesis, yet its role in human endothelial-to-hematopoietic transition (EHT) remains unclear. Comparing human in vivo and in vitro EHT transcriptomes revealed SPI1’s regulatory role. Knocking down SPI1 durin
Externí odkaz:
https://doaj.org/article/a5569b62223741b38c5228dc1546d065
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Hemogenic endothelium (HE) with hematopoietic stem cell (HSC)-forming potential emerge from specialized arterial endothelial cells (AECs) undergoing the endothelial-to-hematopoietic transition (EHT) in the aorta-gonad-mesonephros (AGM) regio
Externí odkaz:
https://doaj.org/article/05a9dc899dad41cbb22b701315b43b4d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/4441d61257f146ac9c2c718a875ccc15
Autor:
Yajie Wang, Ting Lu, Guohuan Sun, Yawei Zheng, Shangda Yang, Hongyan Zhang, Sha Hao, Yanfeng Liu, Shihui Ma, Houyu Zhang, Yongxin Ru, Shaorong Gao, Kuangyu Yen, Hui Cheng, Tao Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Yamanaka factors can reprogram somatic and cancer cells into induced pluripotent stem cells. Here, the authors show that the induction of these factors in acute myeloid leukemia leads to apoptosis of leukemia cells in vivo, and this is through modula
Externí odkaz:
https://doaj.org/article/74b5e3075d964424ba332b6b527e4378
Autor:
Rongtao Xue, Ying Wang, Tienan Wang, Mei Lyu, Guiling Mo, Xijie Fan, Jianchao Li, Kuangyu Yen, Shihui Yu, Qifa Liu, Jin Xu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ELMO1 (Engulfment and Cell Motility1) is a gene involved in regulating cell motility through the ELMO1-DOCK2-RAC complex. Contrary to DOCK2 (Dedicator of Cytokinesis 2) deficiency, which has been reported to be associated with immunodeficiency diseas
Externí odkaz:
https://doaj.org/article/f418a53ddb934d4d935944a6117fc946
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
RUNX1 is a Runt family transcription factor that plays a critical role in normal hematopoiesis, including the differentiation and proliferation of hematopoietic cells. RUNX1 mutations, including chromosomal translocations, cause abnormal cell differe
Externí odkaz:
https://doaj.org/article/f440e49d20af49f5b464efbf8f26d1e8
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Acute myeloid leukemia (AML) refers to a heterogeneous group of hematopoietic malignancies. The well-known European Leukemia Network (ELN) stratifies AML patients into three risk groups, based primarily on the detection of cytogenetic abnormalities.
Externí odkaz:
https://doaj.org/article/a9a9fcd3de3842ebb5647385ffada789
Publikováno v:
SCIENTIA SINICA Vitae. 52:1540-1552
Publikováno v:
Journal of Genetics and Genomics. 48:1081-1090
The Metronidazole (MTZ)/nitroreductase (NTR)-mediated cell ablation system is the most commonly used chemical-genetic cell ablation method in zebrafish. This system can specifically ablate target cells under spatial and temporal control. The MTZ/NTR
Autor:
Jianyu Yang, Ting Lu, Shan Liu, Tao Cheng, Houyu Zhang, Kuangyu Yen, Jin Xu, Guohuan Sun, Fangyao Chen
Publikováno v:
NAR Genomics and Bioinformatics
Tn5 transposase, which can efficiently tagment the genome, has been widely adopted as a molecular tool in next-generation sequencing, from short-read sequencing to more complex methods such as assay for transposase-accessible chromatin using sequenci