Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Kuang-Yuh Chyu"'
Autor:
Fernando Chernomordik, Bojan Cercek, Jianchang Zhou, Xiaoning Zhao, Nicole Wai Man Lio, Kuang-Yuh Chyu, Prediman K. Shah, Paul C. Dimayuga
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundLL-37 is the only member of the cathelicidin family of antimicrobial peptides in humans and is an autoantigen in several autoimmune diseases and in acute coronary syndrome (ACS). In this report, we profiled the specific T cell response to t
Externí odkaz:
https://doaj.org/article/05b2d9f173b040cbbb3502583f721a77
Autor:
Kuang-Yuh Chyu, Xiaoning Zhao, Jianchang Zhou, Paul C. Dimayuga, Nicole W.M. Lio, Bojan Cercek, Noah T. Trac, Eun Ji Chung, Prediman K. Shah
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Active immunization with the apolipoprotein B-100 (ApoB-100) peptide P210 reduces experimental atherosclerosis. To advance this immunization strategy to future clinical testing, we explored the possibility of delivering P210 as an antigen using nanop
Externí odkaz:
https://doaj.org/article/4202e41de15b4c3bbae14b89cc4e796c
Autor:
Fernando Chernomordik, Bojan Cercek, Wai Man Lio, Peter M. Mihailovic, Juliana Yano, Romana Herscovici, Xiaoning Zhao, Jianchang Zhou, Kuang-Yuh Chyu, Prediman K. Shah, Paul C. Dimayuga
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The human cationic anti-microbial peptide LL-37 is a T cell self-antigen in patients with psoriasis, who have increased risk of cardiovascular events. However, the role of LL-37 as a T cell self-antigen in the context of atherosclerosis remains uncle
Externí odkaz:
https://doaj.org/article/44faf2073cbf430cb195ca7982802839
Autor:
Wai Man Lio, Bojan Cercek, Juliana Yano, Wei Yang, Jonathan Ghermezi, Xiaoning Zhao, Jianchang Zhou, Bo Zhou, Michael R. Freeman, Kuang-Yuh Chyu, Prediman K. Shah, Paul C. Dimayuga
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A significant body of work implicates the adaptive immune response in atherosclerosis, the main underlying cause of coronary artery disease (CAD), yet specific antigens involved remain to be fully identified. The pathobiology of CAD is influenced by
Externí odkaz:
https://doaj.org/article/9a821ab2747b4c3c82fd7c4223632e38
Autor:
Peter M. Mihailovic, Wai Man Lio, Juliana Yano, Jianchang Zhou, Xiaoning Zhao, Kuang-Yuh Chyu, Prediman K. Shah, Bojan Cercek, Paul C. Dimayuga
Publikováno v:
Biochemistry and Biophysics Reports, Vol 19, Iss , Pp - (2019)
Modulating inflammation by targeting IL-1β reduces recurrent athero-thrombotic cardiovascular events without lipid lowering. This presents an opportunity to explore other pathways associated with the IL-1β signaling cascade to modulate the inflamma
Externí odkaz:
https://doaj.org/article/64042e09a3294ffdade6cbdf29c5d3ac
Autor:
Peter M Mihailovic, Wai Man Lio, Romana Herscovici, Kuang-Yuh Chyu, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Bo Zhou, Michael R Freeman, Wei Yang, Prediman K Shah, Bojan Cercek, Paul C Dimayuga
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0213025 (2019)
BackgroundInflammation is an important risk factor in atherosclerosis, the underlying cause of coronary artery disease (CAD). Unresolved inflammation may result in maladaptive immune responses and lead to immune reactivity to self-antigens. We hypoth
Externí odkaz:
https://doaj.org/article/014031a96f3b47f685e1a1c71d8e3059
Autor:
Paul C. Dimayuga, Xiaoning Zhao, Juliana Yano, Wai Man Lio, Jianchang Zhou, Peter M. Mihailovic, Bojan Cercek, Prediman K. Shah, Kuang‐Yuh Chyu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 7 (2017)
BackgroundT cells are found in atherosclerotic plaques, with evidence supporting a potential role for CD8+ T cells in atherogenesis. Prior studies provide evidence of low‐density lipoprotein and apoB‐100 reactive T cells, yet specific epitopes re
Externí odkaz:
https://doaj.org/article/d61ef3d4a72e424986bc7fa385e4da06
Autor:
Peter M Mihailovic, Wai Man Lio, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Kuang-Yuh Chyu, Prediman K Shah, Bojan Cercek, Paul C Dimayuga
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187432 (2017)
Auto-immunity is believed to contribute to inflammation in atherosclerosis. The antimicrobial peptide LL-37, a fragment of the cathelicidin protein precursor hCAP18, was previously identified as an autoantigen in psoriasis. Given the reported link be
Externí odkaz:
https://doaj.org/article/d1cdaf5574f845f5a7c50607c214720c
Autor:
Tomoyuki Honjo, Kuang-Yuh Chyu, Paul C Dimayuga, Wai Man Lio, Juliana Yano, Portia Trinidad, Xiaoning Zhao, Jianchang Zhou, Bojan Cercek, Prediman K Shah
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131731 (2015)
Recent studies suggest the potential involvement of CD8+ T cells in the pathogenesis of murine hypertension. We recently reported that immunization with apoB-100 related peptide, p210, modified CD8+ T cell function in angiotensin II (AngII)-infused a
Externí odkaz:
https://doaj.org/article/f64b3b290e55492693eff7776f0b2d6b
Autor:
Kuang-Yuh Chyu, Wai Man Lio, Paul C Dimayuga, Jianchang Zhou, Xiaoning Zhao, Juliana Yano, Portia Trinidad, Tomoyuki Honjo, Bojan Cercek, Prediman K Shah
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92095 (2014)
The lipid milleu exacerbates the inflammatory response in atherosclerosis but its effect on T cell mediated immune response has not been fully elucidated. We hypothesized that lipid lowering would modulate T cell mediated immune function.T cells isol
Externí odkaz:
https://doaj.org/article/ee054644e1fc4428b850d64d3357fdf7