Výsledky vyhledávání - "Kuang-Hsing Shih"

Supplementary Materials and Methods, Supplementary Table 1, and Supplementary Figures 1 and 2 from MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

Autor: Jang-Yang Chang, Joseph T. Tseng, Wen-Yu Pan, Chi-Yen Chang, Kuang-Hsing Shih, Wen-Yang Lai, Ching-Chuan Kuo, Jing-Ping Liou, Yun-Ching Cheng

PDF - 361KB, Supplementary Materials and Methods; Table S1: Primary Antibodies and secondary antibodies; Figure S1: Effect of MPT0B098 on the organizations of cellular microtubule network; Figure S2: Effect of MPT0B098 on HIF-regulated genes in A549

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fb24acf00ae07d78376bd6c9f218e4
https://doi.org/10.1158/1535-7163.22500639.v1

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Data from MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

Autor: Jang-Yang Chang, Joseph T. Tseng, Wen-Yu Pan, Chi-Yen Chang, Kuang-Hsing Shih, Wen-Yang Lai, Ching-Chuan Kuo, Jing-Ping Liou, Yun-Ching Cheng

Microtubule inhibitors have been shown to inhibit hypoxia-inducible factor-1α (HIF-1α) expression through inhibition translation or enhancing protein degradation. Little is known of the effect of microtubule inhibitors on the stability of HIF-1α m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218640820bf2f6bca3353fa3d414cc67
https://doi.org/10.1158/1535-7163.c.6536526.v1

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MPT0B098, a novel microtubule inhibitor that destabilizes the hypoxia-inducible factor-1α mRNA through decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR

Autor: Wen Yang Lai, Joseph T. Tseng, Wen Yu Pan, Chi Yen Chang, Ching Chuan Kuo, Yun Ching Cheng, Kuang Hsing Shih, Jing Ping Liou, Jang Yang Chang

Publikováno v: Molecular cancer therapeutics. 12(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccb18e850dbd4331db112292d22270b
https://pubmed.ncbi.nlm.nih.gov/23619299

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5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Autor: Chih Ying Nien, Kuang Hsing Shih, Wen Yang Lai, Ching Chuan Kuo, Chi Yen Chang, Hsueh Yun Lee, Jang Yang Chang, Chun Hsein Wu, Jing Ping Liou

Publikováno v: Journal of medicinal chemistry. 54(24)

A variety of studies on the modification of combretastatin A-4 triggered our interest in the impact of the linkers between the 3,4,5-trimethoxyphenyl ring and 5-amino-6-methoxyquinoline on biological activity. The replacement of the carbonyl group wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39e1a9789863b570fc13a2f469a7214
https://pubmed.ncbi.nlm.nih.gov/22060033

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Correction: MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

Autor: Wen Yu Pan, Yun Ching Cheng, Chi Yen Chang, Ching Chuan Kuo, Joseph T. Tseng, Jing Ping Liou, Kuang Hsing Shih, Wen Yang Lai, Jang Yang Chang

Publikováno v: Molecular Cancer Therapeutics. 12:1919-1919

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47b0053a06916a1d8c0d46a0f59067f5
https://doi.org/10.1158/1535-7163.mct-13-0549

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Akademický článek

5-Amino-2-aroylquinolinesas Highly Potent Tubulin Polymerization Inhibitors. Part 2. The Impactof Bridging Groups at Position C-2.

Autor: Hsueh-Yun Lee, Jang-Yang Chang, Chih-Ying Nien, Ching-Chuan Kuo, Kuang-Hsing Shih, Chun-Hsein Wu, Chi-Yen Chang, Wen-Yang Lai, Jing-Ping Liou

Publikováno v: Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8517-8525, 9p

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