Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Kuang‐Hueih Chen"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy, inflammation, fibrosis, and ultimately failure of the right ventricle (RVF). Des
Externí odkaz:
https://doaj.org/article/64554359d0784373a842712ef55189d2
Autor:
Stephen L. Archer, Asish Dasgupta, Kuang-Hueih Chen, Danchen Wu, Kaushal Baid, John E. Mamatis, Victoria Gonzalez, Austin Read, Rachel ET. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Kimberly J. Dunham-Snary, Gerald A. Evans, Gary Levy, Oliver Jones, Ruaa Al-Qazazi, Brooke Ring, Elahe Alizadeh, Charles CT. Hindmarch, Jenna Rossi, Patricia DA. Lima, Darryl Falzarano, Arinjay Banerjee, Che C. Colpitts
Publikováno v:
Redox Biology, Vol 58, Iss , Pp 102508- (2022)
Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/e159da1d54f348208fca210ce85dc53f
Autor:
Ping Yu Xiong, Lian Tian, Kimberly J. Dunham-Snary, Kuang-Hueih Chen, Jeffrey D. Mewburn, Monica Neuber-Hess, Ashley Martin, Asish Dasgupta, Francois Potus, Stephen L. Archer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Introduction: Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF)
Externí odkaz:
https://doaj.org/article/a16e88c2eeca4250a705d66bd834b54e
Autor:
Lian Tian, Francois Potus, Danchen Wu, Asish Dasgupta, Kuang-Hueih Chen, Jeffrey Mewburn, Patricia Lima, Stephen L. Archer
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Introduction: Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation of the mitochondrial fission
Externí odkaz:
https://doaj.org/article/7f09044972fa4db6853a2ec1ce283032
Autor:
Wu, Danchen, Jansen-van Vuuren, Ross D., Dasgupta, Asish, Al-Qazazi, Ruaa, Kuang-Hueih Chen, Martin, Ashley Y., Mewburn, Jeffrey D., Alizadeh, Elahe, Lima, Patricia D. A., Jones, Oliver, Colpman, Pierce, Bentley, Rachel E. T., VandenBroek, M. Martin, Breault, Nolan M., Emon, Isaac M., Yerramilli, V. Siddartha, Jedlovčnik, Luka, Yuan Yuan Zhao, Wells, Michael, Sutendra, Gopinath
Publikováno v:
Hypertension (0194911X); Oct2024, Vol. 81 Issue 10, p2189-2201, 13p
Autor:
Austin Read, Danchen Wu, Stephen L. Archer, Kuang-Hueih Chen, Asish Dasgupta, Jeffrey Mewburn, Mehras Motamed, Elahe Alizadeh, Kimberly J. Dunham-Snary, Lian Tian, Ruaa Al-qazazi, Rachel Bentley
Publikováno v:
Free Radic Biol Med
The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO(2)-respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ed06ba00a7d3e1e683206c52f101e7
https://doi.org/10.1016/j.freeradbiomed.2020.12.452
https://doi.org/10.1016/j.freeradbiomed.2020.12.452
Autor:
Ruaa Al-Qazazi, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins, Stephen L. Archer
Publikováno v:
American journal of respiratory and critical care medicine. 206(5)
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may promote RVF in PAH. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0c4693362c46c46100c6dbdf2f16d4
https://pubmed.ncbi.nlm.nih.gov/35704289
https://pubmed.ncbi.nlm.nih.gov/35704289
Autor:
Charles C.T. Hindmarch, François Potus, Lian Tian, Zhigang Hong, Danchen Wu, Jeffrey Mewburn, Steeve Provencher, Kuang-Hueih Chen, Gopinath Sutendra, Asish Dasgupta, Shelby Kutty, Yuan Yuan Zhao, Sébastien Bonnet, Stephen L. Archer, Patricia D.A. Lima
Publikováno v:
Circ Res
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts (RVfib), these cells are understudied. Objective: Examine the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73678ff9b29fd592b8281312181b57aa
https://doi.org/10.1161/circresaha.120.316443
https://doi.org/10.1161/circresaha.120.316443
Autor:
Elizabeth Lightbody, Bruce E. Elliott, Stephen L. Archer, Edward A. Sykes, Patricia D.A. Lima, Kuang-Hueih Chen, Ashley Martin, Charles C.T. Hindmarch, Yolanda Madarnas, Sandip SenGupta, Leah R. G. Parlow, Jeffrey Mewburn, Christopher J. Nicol, Chandrakant Tayade, Danchen Wu, Victoria Hoskin, Asish Dasgupta
Publikováno v:
The FASEB Journal. 34:5106-5127
Excessive proliferation and apoptosis-resistance are hallmarks of cancer. Increased dynamin-related protein 1 (Drp1)-mediated mitochondrial fission is one of the mediators of this phenotype. Mitochondrial fission that accompanies the nuclear division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148d112ecd0d5709b0d7e64a27be123b
https://doi.org/10.1096/fj.201903117r
https://doi.org/10.1096/fj.201903117r
Autor:
Ping Yu Xiong, Mehras Motamed, Kuang‐Hueih Chen, Asish Dasgupta, François Potus, Lian Tian, Ashley Martin, Jeffrey Mewburn, Oliver Jones, Arthur Thébaud, Stephen L. Archer
Publikováno v:
Acta Physiol (Oxf)
Introduction: Group 2 pulmonary hypertension (PH) has no approved PH-targeted therapy. Metabolic remodelling, specifically a biventricular increase in pyruvate kinase muscle (PKM) isozyme 2 to 1 ratio, occurs in rats with group 2 PH induced by supra-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6e3978f620dffef9ede432ec0d83aa
https://doi.org/10.1111/apha.13764
https://doi.org/10.1111/apha.13764