Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kuan-Hsiang Gary Huang"'
Autor:
Brian G. Feagan, William J. Sandborn, Bruce E. Sands, Yan Liu, Marion Vetter, Susan D. Mathias, Kuan-Hsiang Gary Huang, Jewel Johanns, Matthew Germinaro, Chenglong Han
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Background This study evaluated the content validity and psychometric properties of the Patient-Reported Outcomes Measurement Information System® (PROMIS)-Fatigue Short Form 7a (SF-7a) v1.0 scale to determine its suitability in clinical tri
Externí odkaz:
https://doaj.org/article/a744e3da26794e7494a9b5aa0e4fb834
Autor:
Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W. J. Huizinga, Gustavo Citera, Kuan-Hsiang Gary Huang, Chun Wu, Sean E. Connolly, Yedid Elbez, Robert Wong, Karissa Lozenski, Roy Fleischmann
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background AVERT-2 (a phase IIIb, two-stage study) evaluated abatacept + methotrexate versus methotrexate alone, in methotrexate-naive, anti-citrullinated protein antibody-positive patients with early (≤ 6 months), active RA. This subanaly
Externí odkaz:
https://doaj.org/article/6d0a8a1b51f94829ba8345f63f12219d
Autor:
Paul Emery, Yoshiya Tanaka, Vivian P. Bykerk, Thomas W. J. Huizinga, Gustavo Citera, Clifton O. Bingham, Subhashis Banerjee, Benjamin P. Soule, Marleen Nys, Sean E. Connolly, Karissa L. Lozenski, Joe Zhuo, Robert Wong, Kuan-Hsiang Gary Huang, Roy Fleischmann
Publikováno v:
Rheumatology and Therapy, Vol 10, Iss 3, Pp 707-727 (2023)
Abstract Introduction One target of rheumatoid arthritis (RA) treatment is to achieve early sustained remission; over the long term, patients in sustained remission have less structural joint damage and physical disability. We evaluated Simplified Di
Externí odkaz:
https://doaj.org/article/031a80a1de6645ab8805525b4951051a
Autor:
Duncan S. Palmer, Isaac Turner, Sarah Fidler, John Frater, Dominique Goedhals, Philip Goulder, Kuan-Hsiang Gary Huang, Annette Oxenius, Rodney Phillips, Roger Shapiro, Cloete van Vuuren, Angela R. McLean, Gil McVean
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Various host factors may impact within-host pathogen evolution. Here, the authors develop a Bayesian approach for identifying host-pathogen interactions using large data sets of pathogen diversity, and apply it to investigate HLA-induced selection in
Externí odkaz:
https://doaj.org/article/b513ef14a40046d784ee66ab99f729af
Autor:
Emily Adland, Paolo Paioni, Christina Thobakgale, Leana Laker, Luisa Mori, Maximilian Muenchhoff, Anna Csala, Margaret Clapson, Jacquie Flynn, Vas Novelli, Jacob Hurst, Vanessa Naidoo, Roger Shapiro, Kuan-Hsiang Gary Huang, John Frater, Andrew Prendergast, Julia G Prado, Thumbi Ndung'u, Bruce D Walker, Mary Carrington, Pieter Jooste, Philip J R Goulder
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004954 (2015)
HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell
Externí odkaz:
https://doaj.org/article/47befb569ead468d89d7765d7369e30d
Autor:
Philippa C Matthews, Jennifer Listgarten, Jonathan M Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, Dewald Steyn, Cloete van Vuuren, Paolo Paioni, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Zenele Mncube, Thumbi Ndung'u, Bruce D Walker, David Heckerman, Philip J R Goulder
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47799 (2012)
BACKGROUND:HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage di
Externí odkaz:
https://doaj.org/article/223ab9c411464a6d9824377365c855a0
Autor:
Kuan-Hsiang Gary Huang, Dominique Goedhals, Jonathan M Carlson, Mark A Brockman, Swati Mishra, Zabrina L Brumme, Stephen Hickling, Christopher S W Tang, Toshiyuki Miura, Chris Seebregts, David Heckerman, Thumbi Ndung'u, Bruce Walker, Paul Klenerman, Dewald Steyn, Philip Goulder, Rodney Phillips, Bloemfontein-Oxford Collaborative Group, Cloete van Vuuren, John Frater
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19018 (2011)
We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensator
Externí odkaz:
https://doaj.org/article/205c8bdd298549eca9c757993051237e
Autor:
Victoria O Kasprowicz, Jessica E Mitchell, Shivan Chetty, Pamla Govender, Kuan-Hsiang Gary Huang, Helen A Fletcher, Daniel P Webster, Sebastian Brown, Anne Kasmar, Kerry Millington, Cheryl L Day, Nompumelelo Mkhwanazi, Cheryl McClurg, Fundisiwe Chonco, Ajit Lalvani, Bruce D Walker, Thumbi Ndung'u, Paul Klenerman
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e20606 (2011)
Here we describe the development and validation of a highly sensitive assay of antigen-specific IFN-γ production using real time quantitative PCR (qPCR) for two reporters--monokine-induced by IFN-γ (MIG) and the IFN-γ inducible protein-10 (IP10).
Externí odkaz:
https://doaj.org/article/04542a1dbce8416b86f5607d541fef1e
Autor:
Angela R. McLean, Sarah Fidler, Kuan-Hsiang Gary Huang, Gil McVean, Philip J. R. Goulder, John Frater, Duncan S. Palmer, Cloete van Vuuren, Rodney E. Phillips, Dominique Goedhals, Roger L. Shapiro, Annette Oxenius, Isaac Turner
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10 (1)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10 (1)
Differences among hosts, resulting from genetic variation in the immune system or heterogeneity in drug treatment, can impact within-host pathogen evolution. Genetic association studies can potentially identify such interactions. However, extensive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45882c947b54abf5d3b7293afc0719f4
