Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kuan-Han Hank Wu"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Tumor mutational burden (TMB) is associated with clinical response to immunotherapy, but application has been limited to a subset of cancer patients. We hypothesized that advanced machine-learning and proper modeling could identify mutations
Externí odkaz:
https://doaj.org/article/e53d57ff3e1b4551bda14782b610fbfc
Autor:
Balabhadrapatruni VSK Chakravarthi, Pavithra Dedigama-Arachchige, Shannon Carskadon, Shanker Kalyana Sundaram, Jia Li, Kuan-Han Hank Wu, Darshan Shimoga Chandrashekar, James O Peabody, Hans Stricker, Clara Hwang, Dhananjay A Chitale, Sean R Williamson, Nilesh S Gupta, Nora M Navone, Craig Rogers, Mani Menon, Sooryanarayana Varambally, Nallasivam Palanisamy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 989-1002 (2019)
We present the functional characterization of a pseudogene associated recurrent gene fusion in prostate cancer. The fusion gene KLK4-KLKP1 is formed by the fusion of the protein coding gene KLK4 with the noncoding pseudogene KLKP1. Screening of a coh
Externí odkaz:
https://doaj.org/article/9cb7c1c1d0ee478f8e60a7e5a6160896
Autor:
Alexandra R. Sitarik, Manish Arora, Christine Austin, Lawrence F. Bielak, Shoshannah Eggers, Christine C. Johnson, Susan V. Lynch, Sung Kyun Park, Kuan-Han Hank Wu, Germaine J.M. Yong, Andrea E. Cassidy-Bushrow
Publikováno v:
Environment International, Vol 144, Iss , Pp 106062- (2020)
Background: Lead (Pb) is an environmentally ubiquitous heavy metal associated with a wide range of adverse health effects in children. Both lead exposure and the early life microbiome— which plays a critical role in human development—have been li
Externí odkaz:
https://doaj.org/article/b2b0b6249871442a9db1c0802c94c3f0
Autor:
Xiaohui Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Fengjie Wang, Kuan-Han Hank Wu, Michael Chopp, Jieli Chen, Xu Cui
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3368 (2018)
The ATP-binding cassette transporter member A1 (ABCA1) and apolipoprotein E (ApoE) are major cholesterol transporters that play important roles in cholesterol homeostasis in the brain. Previous research demonstrated that specific deletion of brain-AB
Externí odkaz:
https://doaj.org/article/3d7f503181cd49d8b4c550a2506b9061
Autor:
Stuart C. Gordon, Joseph A. Boscarino, Jennifer Vincent, Jia Li, Keith D. Lindor, Robert J. Romanelli, Sheri Trudeau, Fold Investigators, Jeffrey J. VanWormer, Christopher L. Bowlus, Amandeep Sahota, Heather Anderson, Yihe G. Daida, Carla Rodriguez-Watson, Loralee B Rupp, Christina Melkonian, Kuan-Han Hank Wu, Yueren Zhou, Mei Lu, Mark A Schmidt, Irina V. Haller
Publikováno v:
Digestive Diseases and Sciences. 67:4170-4180
Ursodeoxycholic acid (UDCA) remains the first-line therapy for primary biliary cholangitis (PBC); however, inadequate treatment response (ITR) is common. The UK-PBC Consortium developed the modified UDCA Response Score (m-URS) to predict ITR (using a
Autor:
Lawrence F. Bielak, Kuan-Han Hank Wu, Christine Austin, Alexandra R. Sitarik, Andrea E. Cassidy-Bushrow, Christine Cole Johnson, Paul Curtin, Sung Kyun Park, Manish Arora, Chris Gennings
Publikováno v:
Environmental Research. 171:444-451
A growing number of studies have examined associations of metal exposures with birth outcomes, however, results from these studies have been inconsistent, and hampered by methodological limitations. We measured direct fetal exposure to three metals (
Autor:
Heather Anderson, Irina V. Haller, Robert J. Romanelli, Kuan-Han Hank Wu, Jia Li, Amandeep Sahota, Sheri Trudeau, Fold Investigators, Loralee B Rupp, Stuart C. Gordon, Mei Lu, Mark A Schmidt, Christopher L. Bowlus, Talan Zhang, Jeffrey J. VanWormer, Carla V. Rodriguez, Jennifer Vincent, Joseph A. Boscarino, Keith D. Lindor, Yihe G. Daida
Publikováno v:
The American journal of gastroenterology. 115(2)
Background We used data from the Fibrotic Liver Disease Consortium to evaluate the impact of ursodeoxycholic acid (UDCA) treatment across race/ethnicity, gender, and clinical status among patients with primary biliary cholangitis. Methods Data were c
Autor:
Darshan S. Chandrashekar, Dhananjay Chitale, Sean R. Williamson, Mani Menon, Sooryanarayana Varambally, Jia Li, Craig G. Rogers, Balabhadrapatruni V. S. K. Chakravarthi, James O. Peabody, Pavithra Dedigama-Arachchige, Clara Hwang, Kuan Han Hank Wu, Nallasivam Palanisamy, Nora M. Navone, Shanker Kalyana Sundaram, Shannon Carskadon, Hans Stricker, Nilesh S. Gupta
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 989-1002 (2019)
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 989-1002 (2019)
Analysis of next generation transcriptome sequencing data of prostate cancer identified a novel gene fusion formed by the fusion of a protein coding gene (KLK4) with a non-coding pseudogene (KLKP1) and expression of its cognate protein. Screening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b86b70a262f218b0eac3a6d28c39be1
https://doi.org/10.1101/666933
https://doi.org/10.1101/666933
Autor:
Christine Cole Johnson, Shoshannah Eggers, Kuan-Han Hank Wu, Lawrence F. Bielak, Sung Kyun Park, Andrea E. Cassidy-Bushrow, Germaine J. M. Yong, Manish Arora, Susan V. Lynch, Christine Austin, Alexandra R. Sitarik
Publikováno v:
Environment International, Vol 144, Iss, Pp 106062-(2020)
Environ Int
Environ Int
Background: Lead (Pb) is an environmentally ubiquitous heavy metal associated with a wide range of adverse health effects in children. Both lead exposure and the early life microbiome— which plays a critical role in human development—have been li
Autor:
Xu Cui, Xiaohui Wang, Kuan-Han Hank Wu, Julie Landschoot-Ward, Rongwen Li, Jieli Chen, Fengjie Wang, Michael Chopp, Alex Zacharek
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3368 (2018)
Volume 19
Issue 11
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3368 (2018)
Volume 19
Issue 11
The ATP-binding cassette transporter member A1 (ABCA1) and apolipoprotein E (ApoE) are major cholesterol transporters that play important roles in cholesterol homeostasis in the brain. Previous research demonstrated that specific deletion of brain-AB