Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kuan-Chuan Pao"'
Autor:
Peter D. Mabbitt, Michael P. Coleman, Satpal Virdee, Marc-André Déry, Mathew Stanley, Adam J. Fletcher, Andrea Loreto, Nicola T. Wood, Kuan-Chuan Pao
Publikováno v:
Nature Chemical Biology. 16:1227-1236
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a34b16eb3e4d1236aa0e426512e9373
https://doi.org/10.1038/s41589-020-0598-6
https://doi.org/10.1038/s41589-020-0598-6
Autor:
Kuan Chuan Pao, Michael Rape
Publikováno v:
Trends in Cell Biology. 29:767-769
Xenophagy, the process of eliminating intracellular pathogens through the autophagy machinery, is an important defense mechanism against infectious disease, yet the underlying molecular mechanisms remain incompletely understood. Recent work (Xu et al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a192b45664a61ab44817e21b51dad1
https://doi.org/10.1016/j.tcb.2019.08.001
https://doi.org/10.1016/j.tcb.2019.08.001
Autor:
Peter D, Mabbitt, Andrea, Loreto, Marc-André, Déry, Adam J, Fletcher, Mathew, Stanley, Kuan-Chuan, Pao, Nicola T, Wood, Michael P, Coleman, Satpal, Virdee
Publikováno v:
Nature chemical biology. 16(11)
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aaaedfcad6589562f658118747d5855
https://pubmed.ncbi.nlm.nih.gov/33067595
https://pubmed.ncbi.nlm.nih.gov/33067595
Autor:
Tzong Shyuan Lee, Chien-Chung Han, Jin Feng Zhao, Ying Pei Huang, Kuan Chuan Pao, Lin Chiang Sherlock Huang, Kou Hung Wu, Ming Hua Hsu
Publikováno v:
RSC Advances. 5:5652-5656
Here, we present a series of novel paeonol derivatives that prevent lipid accumulation at lower doses and exhibit improved water solubility. According to SAR analysis results, 1-(4-methoxy-2-(2-(piperidin-1-yl)ethoxy)phenyl)ethanone (6a) and 4′-met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3e4d4daa991fa4db8075a9f971673ea
https://doi.org/10.1039/c4ra13986k
https://doi.org/10.1039/c4ra13986k
Autor:
Axel Knebel, Kuan-Chuan Pao, Kay Hofmann, Peter D. Mabbitt, Satpal Virdee, Karim Rafie, Ramasubramanian Sundaramoorthy, Daan M. F. van Aalten, Nicola T. Wood, Mathew Stanley
Publikováno v:
Nature. 556(7701)
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2–Ub)1. Ubiquitin ligases (E3s) of the ‘really interesting new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844a6e68f3899c99a0900ec35c9cb64c
https://pubmed.ncbi.nlm.nih.gov/29643511
https://pubmed.ncbi.nlm.nih.gov/29643511
Autor:
Song-Kun Shyue, Tzong Shyuan Lee, Ming Hua Hsu, Jin Feng Zhao, Sheng Huang Hsiao, Yu Ru Kou, Kuan Chuan Pao
Publikováno v:
Archives of Toxicology. 90:181-190
Di-(2-ethylhexyl) phthalate (DEHP) is associated with atherosclerosis-related cardiovascular disease complications, but we lack direct evidence of its unfavorable effect on atherogenesis. In this study, we aimed to clarify in vivo and in vitro the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b03ca29a924083e72dd1a62af247ef
https://doi.org/10.1007/s00204-014-1377-5
https://doi.org/10.1007/s00204-014-1377-5
Autor:
Ming Hua Hsu, Kou Hung Wu, Cheng Ying Hsieh, Fa Kuen Shieh, Pi Wen Ko, Kuan Chuan Pao, Lin Chiang Sherlock Huang, Radhakrishnan Sureshbabu, Shih Ching Chou
Publikováno v:
Applied Radiation and Isotopes. 89:53-57
This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1942290c4b0171329c06bb4fd62fbd9
https://doi.org/10.1016/j.apradiso.2014.02.006
https://doi.org/10.1016/j.apradiso.2014.02.006
Autor:
Fong Yu Cheng, Chien-Chung Han, Fa Kuen Shieh, Chung Chang Lin, Fu Yuan Tsai, Hong Chuang, Dian Syue Wu, Kuan Chuan Pao, Ying Pei Huang, Ming Hua Hsu, Chia-Ching Chang, Shih Ching Chou
Publikováno v:
RSC Adv.. 4:14777-14780
We established a highly efficient and simple method to directly functionalize the surface of carbon nanotubes (CNTs) with thiol groups (–SH). The –SH groups on the surface of the CNTs were characterized using Raman spectroscopy, X-ray photoelectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a2d7f8502a8ba8e710c9e2b1aa821bc
https://doi.org/10.1039/c4ra00051j
https://doi.org/10.1039/c4ra00051j
Autor:
Satpal Virdee, Paul Murphy, Kristin Balk, Cong Han, Mathew Stanley, Yu-Chiang Lai, Kuan Chuan Pao, Miratul M. K. Muqit, Olga Corti, Jean-Christophe Corvol, Nicola T. Wood
Publikováno v:
Nature chemical biology
E3 ligases represent an important class of enzymes, yet there are currently no chemical probes for profiling their activity. We develop a new class of activity-based probe by re-engineering a ubiquitin-charged E2 conjugating enzyme and demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5385cfe13a7d4c5bc003b0713830fd55
https://pubmed.ncbi.nlm.nih.gov/26928937
https://pubmed.ncbi.nlm.nih.gov/26928937
Publikováno v:
Chembiochem
Ubiquitin phosphorylation is emerging as an important regulatory layer in the ubiquitin system. This is exemplified by the phosphorylation of ubiquitin on Ser65 by the Parkinson's disease-associated kinase PINK1, which mediates the activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f468fadf62ccd558bd16154f9b1252b0
https://pubmed.ncbi.nlm.nih.gov/26010437
https://pubmed.ncbi.nlm.nih.gov/26010437