Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kuan Yoow Chan"'
Autor:
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen
Publikováno v:
Open Biology, Vol 13, Iss 4 (2023)
Expression and activity of the AMP-activated protein kinase (AMPK) α1 catalytic subunit of the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer patients. Hence there is considerable interest in uncovering signal
Externí odkaz:
https://doaj.org/article/8f517fb0f4714e258cf9dc1d821f5c08
Publikováno v:
Cell Division, Vol 17, Iss 1, Pp 1-13 (2022)
Abstract The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with human diseases ranging from con
Externí odkaz:
https://doaj.org/article/0acc70cb41a24445b1ceb42ff79749e2
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001050 (2010)
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies.
Externí odkaz:
https://doaj.org/article/c273ee251001455cb01c964d07ba1bf1
Autor:
null Kaitlin R. Morrison, null Tingting Wang, null Kuan Yoow Chan, null Eleanor W. Trotter, null Ari Gillespie, null Michael Z. Michael, null Jonathan S. Oakhill, null Iain M. Hagan, null Janni Petersen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ca41fc0da7331dd910ac50764426cb
https://doi.org/10.1098/rsob.230021/v2/response1
https://doi.org/10.1098/rsob.230021/v2/response1
Autor:
Chen Cheng, Linxiao Hou, Xudong Fu, Yuqing Zhu, Lang Chen, Li Zhang, Kuan Yoow Chan, Jin Zhang, Zhen Sun, Hongru Pan, Ling Zhang
Publikováno v:
Stem Cell Reports
Summary Mouse embryonic stem cells (ESCs) show cell-to-cell heterogeneity. A small number of two-cell-like cells (2CLCs) marked by endogenous retrovirus activation emerge spontaneously. The 2CLCs are unstable and they are prone to transiting back to
Autor:
Xukai Gao, Gaoang Wang, Renzhi Yao, Yifan Gui, Ping Wang, Kuan Yoow Chan, Shuangshuang Xie, Yanan Wang, Yutian Dong
Summary Computational methods that track single cells and quantify fluorescent biosensors in time-lapse microscopy images have revolutionized our approach in studying the molecular control of cellular decisions. One barrier that limits the adoption o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba45e022a537afe0a271cf850d9cc23
https://doi.org/10.1101/2021.09.19.460933
https://doi.org/10.1101/2021.09.19.460933
Publikováno v:
Cell division. 17(1)
The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with human diseases ranging from congenital d
Autor:
Yvonne Connolly, Iain M. Hagan, Marisa Alonso-Nuñez, Kayoko Tanaka, Agnes Grallert, Duncan L. Smith, Kuan Yoow Chan
Publikováno v:
Chan, K Y, Alonso-Nuñez, M, Grallert, A, Tanaka, K, Connolly, Y, Smith, D & Hagan, I 2017, ' Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment ', The Journal of cell biology, vol. 216, no. 9, pp. 2795-2812 . https://doi.org/10.1083/jcb.201702172
The Journal of Cell Biology
The Journal of Cell Biology
Events at the fission yeast equivalent of the centrosome, the spindle pole body, determine the timing of mitotic commitment and mitotic exit. Previous work has established that events on Cut12 drive commitment, whereas events on a distinct scaffold,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860d59daad3dc4499120c745d25428e0
https://pure.manchester.ac.uk/ws/files/57875026/Chan_et_al_accepted.pdf
https://pure.manchester.ac.uk/ws/files/57875026/Chan_et_al_accepted.pdf
Autor:
Iain M. Hagan, Duncan L. Smith, Isabel Alvarez-Tabares, Maria-Luisa Alonso-Nuñez, Alasdair M. Robertson, Kayoko Tanaka, Yvonne Connolly, Agnes Grallert, Jose-Miguel Ortiz, Ashapurna Biswas, Marisa Madrid, Kuan Yoow Chan
Publikováno v:
Current Biology. 23:213-222
Summary Background Activation of the Cdk1/cyclin B complex, also known as mitosis-promoting factor (MPF), drives commitment to mitosis. Interphase MPF is inhibited through phosphorylation of Cdk1 by Wee1-related kinases. Because Cdc25 phosphatases re
Autor:
Agnes Grallert, Viesturs Simanis, Iain M. Hagan, Steven Bagley, Andrea Krapp, Avinash Patel, Kuan Yoow Chan, Victor A. Tallada
Publikováno v:
Nature cell biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
PMCID: PMC3549529.-- et al.
Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the sp
Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the sp