Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kuan H Lee"'
Autor:
James W Grau, J Russell Huie, Kuan H Lee, Kevin C Hoy, Yung-Jen eHuang, Joel D Turtle, Misty M. Strain, Kyle M Baumbauer, Rajesh M Miranda, Michelle A Hook, Adam R Ferguson, Sandra M. Garraway
Publikováno v:
Frontiers in Neural Circuits, Vol 8 (2014)
Research has shown that spinal circuits have the capacity to adapt in response to training, nociceptive stimulation and peripheral inflammation. These changes in neural function are mediated by physiological and neurochemical systems analogous to tho
Externí odkaz:
https://doaj.org/article/67b73a12a21b4d1fa0f3488e9e7d9fff
Autor:
Adam R Ferguson, J Russell eHuie, Eric D Crown, Kyle M Baumbauer, Michelle A Hook, Sandra M Garraway, Kuan H Lee, Kevin C Hoy, James W Grau
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Synaptic plasticity within the spinal cord has great potential to facilitate recovery of function after spinal cord injury (SCI). Spinal plasticity can be induced in an activity-dependent manner even without input from the brain after complete SCI. T
Externí odkaz:
https://doaj.org/article/5ee50337a7f24eb192040b1b3c968f21
Autor:
J Russell Huie, Kyle M Baumbauer, Kuan H Lee, Jacqueline C Bresnahan, Michael S Beattie, Adam R Ferguson, James W Grau
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39751 (2012)
Injury-induced overexpression of tumor necrosis factor alpha (TNFα) in the spinal cord can induce chronic neuroinflammation and excitotoxicity that ultimately undermines functional recovery. Here we investigate how TNFα might also act to upset spin
Externí odkaz:
https://doaj.org/article/8637f9c83db44f659a2f124abfa0a268
Autor:
Tayler D. Sheahan, Sarah E. Ross, Margaret C. Wright, Junichi Hachisuka, Kyle M. Baumbauer, Kuan H. Lee, Colleen Cassidy, Peter C. Adelman, Charles A. Warwick, H. Richard Koerber, Kelly M. Smith
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. This study suggests that activation of nonpeptidergic afferents becomes aversive after spared nerve injury through the recruitment of a normally silent polysynaptic pathway.
Most cutaneous C
Most cutaneous C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a785421dd7d694d6e42394c8f2a76c9
http://europepmc.org/articles/PMC8206522
http://europepmc.org/articles/PMC8206522
Autor:
David S.K. Magnuson, Misty M. Strain, Joel D. Turtle, Kuan H. Lee, Mark L. Harlow, Megan M. Tarbet, Kevin C. Hoy, J. Russell Huie, John J. Hartman, James W. Grau
Publikováno v:
J Neurosci
Neurons within the spinal cord are sensitive to environmental relations and can bring about a behavioral modification without input from the brain. For example, rats that have undergone a thoracic (T2) transection can learn to maintain a hind leg in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ebb231157f443d4fd8603b874a857f
https://doi.org/10.1523/jneurosci.2683-19.2020
https://doi.org/10.1523/jneurosci.2683-19.2020
Autor:
Kelly M. Smith, Colleen Cassidy, Junichi Hachisuka, Kuan H. Lee, Peter C. Adelman, Sarah E. Ross, Margaret C. Wright, Charles A. Warwick, H. Richard Koerber, Kyle M. Baumbauer
Most cutaneous C-fibers, including both peptidergic and non-peptidergic subtypes are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, non-peptidergic C-fibers also respond to mechanical inpu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed55a048d387398aadb7119fb2074517
https://doi.org/10.1101/2020.09.17.296384
https://doi.org/10.1101/2020.09.17.296384
Autor:
Kuan H. Lee, James W. Grau, Sandra M. Garraway, Misty M. Strain, Joshua A. Reynolds, Melissa K. Henwood, Joel D. Turtle, Yung-Jen Huang
Publikováno v:
Frontiers in Systems Neuroscience, Vol 12 (2018)
Frontiers in Systems Neuroscience
Frontiers in Systems Neuroscience
Pain (nociceptive) input caudal to a spinal contusion injury increases tissue loss and impairs long-term recovery. It was hypothesized that noxious stimulation has this effect because it engages unmyelinated pain (C) fibers that produce a state of ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339b11b01b16192559ed46e77f3f9893
https://doi.org/10.3389/fnsys.2018.00027
https://doi.org/10.3389/fnsys.2018.00027
Publikováno v:
Experimental neurology. 288
Noxious stimulation can induce a lasting increase in neural excitability within the spinal cord (central sensitization) that can promote pain and disrupt adaptive function (maladaptive plasticity). Brain-derived neurotrophic factor (BDNF) is known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d06e5556317341224c871561a02d266
https://pubmed.ncbi.nlm.nih.gov/27818188
https://pubmed.ncbi.nlm.nih.gov/27818188
Publikováno v:
Experimental neurology. 285
Noxious input can sensitize pain (nociceptive) circuits within the spinal cord, inducing a lasting increase in spinal cord neural excitability (central sensitization) that is thought to contribute to chronic pain. The development of spinally-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4a0818f85bfeb24b61f08de4fa48e4
https://pubmed.ncbi.nlm.nih.gov/27639636
https://pubmed.ncbi.nlm.nih.gov/27639636
Autor:
Sarah A. Woller, James W. Grau, Sandra M. Garraway, J.R. Huie, Michelle A. Hook, Joel D. Turtle, Kuan H. Lee
Publikováno v:
Neuroscience. 199:86-102
Intermittent nociceptive stimulation following a complete transection or contused spinal cord injury (SCI) has been shown to exert several short- and long-lasting negative consequences. These include maladaptive spinal plasticity, enhanced mechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::142976d9c43d5cf6b8672928c50a26d2
https://doi.org/10.1016/j.neuroscience.2011.10.007
https://doi.org/10.1016/j.neuroscience.2011.10.007