Zobrazeno 1 - 10
of 3 778
pro vyhledávání: '"Kuan Chen"'
Autor:
Zhongwen Li, He Xie, Zhouqian Wang, Daoyuan Li, Kuan Chen, Xihang Zong, Wei Qiang, Feng Wen, Zhihong Deng, Limin Chen, Huiping Li, He Dong, Pengcheng Wu, Tao Sun, Yan Cheng, Yanning Yang, Jinsong Xue, Qinxiang Zheng, Jiewei Jiang, Wei Chen
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The main cause of corneal blindness worldwide is keratitis, especially the infectious form caused by bacteria, fungi, viruses, and Acanthamoeba. The key to effective management of infectious keratitis hinges on prompt and precise diagnosis.
Externí odkaz:
https://doaj.org/article/526b9b1555d345e98501c9f8edb6bf6b
Autor:
Jamie Anne Lugtu-Pe, Xuning Zhang, Sako Mirzaie, Hao Han R. Chang, Nour AL-Mousawi, Kuan Chen, Yongqiang Li, Anil Kane, Daniel Bar-Shalom, Xiao Yu Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2669-2684 (2024)
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benef
Externí odkaz:
https://doaj.org/article/4955f5c4544143eda661e42ec109ad16
Autor:
Zhongwen Li, Lei Wang, Wei Qiang, Kuan Chen, Zhouqian Wang, Yi Zhang, He Xie, Shanjun Wu, Jiewei Jiang, Wei Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Smartphone-based artificial intelligence (AI) diagnostic systems could assist high-risk patients to self-screen for corneal diseases (e.g., keratitis) instead of detecting them in traditional face-to-face medical practices, enabling the patients to p
Externí odkaz:
https://doaj.org/article/81d0f4fdb73f4aeb897a50d9c0385d12
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell development in the thymus is dependent on the thymic microenvironment, in which thymic epithelial cells (TECs) are the major component. However, TECs undergo both a qualitative and quantitative loss during aging, which is believed to be the ma
Externí odkaz:
https://doaj.org/article/c9cc0a0d8c8a4e3b84aadc6cbd04cd9a
Autor:
Maura K. Lash, Ned H. Latham, Pui Ying Chan, Mary M.K. Foote, Elizabeth A. Garcia, Matthew F. Silverstein, Marcia Wong, Mark Alexander, Karen A. Alroy, Lovedeep Bajaj, Kuan Chen, James Steele Howard, Lucretia E. Jones, Ellen H. Lee, Julian L. Watkins, Tristan D. McPherson
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 11, Pp 2353-2357 (2023)
We assessed tecovirimat treatment equity for 3,740 mpox patients in New York, New York, USA, during the 2022 mpox emergency; 32.4% received tecovirimat. Treatment rates by race/ethnicity were 38.8% (White), 31.3% (Black/African American), 31.0% (Hisp
Externí odkaz:
https://doaj.org/article/c91893487b4c42f8a8331124102f17cf
Autor:
Hao-Tian Wang, Zi-Long Wang, Kuan Chen, Ming-Ju Yao, Meng Zhang, Rong-Shen Wang, Jia-He Zhang, Hans Ågren, Fu-Dong Li, Junhao Li, Xue Qiao, Min Ye
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are bioactive natural products widely present in the plant kingdom. However, little is known on the key apiosylation reaction in the biosynthetic pathways
Externí odkaz:
https://doaj.org/article/7f3471b02bd948039766a1ff9037b182
Autor:
Linlin Wang, Zhihui Jiang, Jiahe Zhang, Kuan Chen, Meng Zhang, Zilong Wang, Binju Wang, Min Ye, Xue Qiao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Acetylation contributes to the bioactivity of numerous medicinally important natural products. However, little is known about the acetylation on sugar moieties. Here we report a saponin acetyltransferase from Astragalus membranaceus. AmAT7-3
Externí odkaz:
https://doaj.org/article/ff52c7263f8141f18abb2b184e6aa97a
Autor:
Bo-Yun Han, Zi-Long Wang, Junhao Li, Qing Jin, Hao-Tian Wang, Kuan Chen, Yang Yi, Hans Ågren, Xue Qiao, Min Ye
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3535-3544 (2023)
C-Glycosides are important natural products with various bioactivities. In plant biosynthetic pathways, the C-glycosylation step is usually catalyzed by C-glycosyltransferases (CGTs), and most of them prefer to accept uridine 5′-diphosphate glucose
Externí odkaz:
https://doaj.org/article/756cbb59611f48d8ba5dd2c88d29e77b
Autor:
Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao
Publikováno v:
Journal of Advanced Research, Vol 43, Iss , Pp 247-257 (2023)
Introduction: Triterpenoids and saponins have a broad range of pharmacological activities. Unlike most legumes which contain mainly oleanane-type scaffold, Astragalus membranaceus contains not only oleanane-type but also cycloartane-type saponins, fo
Externí odkaz:
https://doaj.org/article/daab007e7de94d94a8d0d7e26f81e5fa
Autor:
Yanju Luo, Kai Zhang, Zhenming Ding, Ping Chen, Xiaomei Peng, Yihuan Zhao, Kuan Chen, Chuan Li, Xujun Zheng, Yan Huang, Xuemei Pu, Yu Liu, Shi-Jian Su, Xiandeng Hou, Zhiyun Lu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, the authors investigate naphthalimide-based compounds with cold triplet excitons utilized by triplet-triplet annihilation-mediated high-lying reverse intersystem crossing, and realize rate constant of over 109 s−1 with exciton utilization eff
Externí odkaz:
https://doaj.org/article/161136e79e244a7eaf84510d637952a7