Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Ku-Lung Hsu"'
Autor:
Andrew J. Heindel, Jeffrey W. Brulet, Xiantao Wang, Michael W. Founds, Adam H. Libby, Dina L. Bai, Michael C. Lemke, David M. Leace, Thurl E. Harris, Markus Hafner, Ku-Lung Hsu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at
Externí odkaz:
https://doaj.org/article/04e8d79101f84503b966141edfd09c6e
Autor:
Syed S. Hussain, Tuyet-Minh Tran, Timothy B. Ware, Melissa A. Luse, Christopher T. Prevost, Ashley N. Ferguson, Jennifer A. Kashatus, Ku-Lung Hsu, David F. Kashatus
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109451- (2021)
Summary: Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and p
Externí odkaz:
https://doaj.org/article/7d1ca44d34e043e18caedbea8c3d9b61
Autor:
Anthony M. Ciancone, Kyung W. Seo, Miaomiao Chen, Adam L. Borne, Adam H. Libby, Dina L. Bai, Ralph E. Kleiner, Ku-Lung Hsu
Publikováno v:
Journal of the American Chemical Society. 145:11056-11066
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a665d6399d403dcc351fb4cfb9c1d44
https://doi.org/10.1021/jacs.3c00165
https://doi.org/10.1021/jacs.3c00165
Autor:
Miaomiao Chen, Myungsun Shin, Ware, Timothy B., Donvito, Giulia, Muchhala, Karan H., Mischel, Ryan, Mustafa, Mohammed A., Serbulea, Vlad, Upchurch, Clint M., Leitinger, Norbert, Akbarali, Hamid I., Lichtman, Aron H., Ku-Lung Hsu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/26/2023, Vol. 120 Issue 52, p1-9, 41p
Autor:
R. Justin Grams, Ku-Lung Hsu
Publikováno v:
Trends Pharmacol Sci
Bioactive small molecules that form covalent bonds with a target protein are important tools for basic research and can be highly effective drugs. This review highlights reactive groups found in a collection of thiophilic and oxophilic drugs that med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d307a96735af1d1ae56d751eb8c8b62
https://doi.org/10.1016/j.tips.2021.12.002
https://doi.org/10.1016/j.tips.2021.12.002
Publikováno v:
Israel Journal of Chemistry. 63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8051da592a72b7d334f7b0b6422b56
https://doi.org/10.1002/ijch.202300001
https://doi.org/10.1002/ijch.202300001
Autor:
Roberto Mendez, Minhaj Shaikh, Michael C. Lemke, Kun Yuan, Adam H. Libby, Dina L. Bai, Mark M. Ross, Thurl E. Harris, Ku-Lung Hsu
Publikováno v:
RSC Chemical Biology.
We provide a family-wide assessment of accessible sites for covalent targeting that combined with AlphaFold revealed predicted small molecule binding pockets for guiding future inhibitor development of the DGK superfamily.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94ee2fd7cfa3e38fed483d10c77bfb51
https://doi.org/10.1039/d3cb00057e
https://doi.org/10.1039/d3cb00057e
Autor:
Ku-Lung Hsu, Keira E. Mahoney, Kun Yuan, Donald F. Hunt, Jeffrey Shabanowitz, Dina L. Bai, Rebecca L. McCloud, Mark M. Ross
Publikováno v:
Anal Chem
Chemical proteomics is widely used for the global investigation of protein activity and binding of small molecule ligands. Covalent probe binding and inhibition are assessed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to gain mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0e0f3fbccb6c2272db29dc190493ed
https://doi.org/10.1021/acs.analchem.1c01591
https://doi.org/10.1021/acs.analchem.1c01591
Autor:
R Justin, Grams, Ku-Lung, Hsu
Publikováno v:
Nature chemical biology. 18(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e26774623288a34dfac6f590ea0c9f2b
https://pubmed.ncbi.nlm.nih.gov/35710618
https://pubmed.ncbi.nlm.nih.gov/35710618
Autor:
Ku-Lung Hsu, Heather A. Ferris, Jeffrey W. Brulet, Mitchell E. Granade, Thurl E. Harris, Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne
Publikováno v:
Chemical Science
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of SuTEx chemistry f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf7e33426ec572ae52cc64d0e7dc2ed
https://doi.org/10.1039/d0sc06623k
https://doi.org/10.1039/d0sc06623k