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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells.

Autor: Lim YJ; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Park SA; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Wang D; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China., Jin W; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Ku WL; Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA., Zhang D; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Xu J; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Patiño LC; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Liu N; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Chen W; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China., Kazmi R; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA., Zhao K; Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA., Zhang YE; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA., Sun L; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China. Electronic address: lingyunsun@nju.edu.cn., Chen W; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA. Electronic address: wchen@nih.gov.

Publikováno v: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114565. Date of Electronic Publication: 2024 Jul 30.

Acute depletion of BRG1 reveals its primary function as an activator of transcription.

Autor: Ren G; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.; College of Animal Science and Technology, Northwest Agriculture and Forest University, Yangling, Xianyang, Shaanxi, China., Ku WL; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Ge G; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Hoffman JA; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, North Carolina, USA., Kang JY; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Tang Q; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Cui K; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., He Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA., Guan Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA., Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA., Liu C; Transgenic Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA., Archer TK; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, North Carolina, USA., Zhao K; Systems Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. zhaok@nhlbi.nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4561. Date of Electronic Publication: 2024 May 29.

The Drosophila histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation.

Autor: Vidaurre V; Department of Biology, The Johns Hopkins University, Baltimore, Maryland, United States of America., Song A; Department of Biology, The Johns Hopkins University, Baltimore, Maryland, United States of America., Li T; Department of Biology, The Johns Hopkins University, Baltimore, Maryland, United States of America., Ku WL; Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America., Zhao K; Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland, United States of America., Qian J; Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Chen X; Howard Hughes Medical Institute, Baltimore, Maryland, United States of America.; Department of Biology, The Johns Hopkins University, Baltimore, Maryland, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 14. Date of Electronic Publication: 2024 Feb 14.

Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.

Autor: Park SA; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Lim YJ; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Ku WL; Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, 20892, MD, USA., Zhang D; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Cui K; Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, 20892, MD, USA., Tang LY; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, 20892, MD, USA., Chia C; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Zanvit P; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Chen Z; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, 20892, MD, USA., Jin W; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Wang D; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Xu J; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Liu O; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Wang F; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Cain A; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Guo N; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Nakatsukasa H; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA., Wu C; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, 20892, MD, USA., Zhang YE; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, 20892, MD, USA., Zhao K; Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, 20892, MD, USA. zhaok@nhlbi.nih.gov., Chen W; Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, 20892, MD, USA. wchen@mail.nih.gov.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 14; Vol. 13 (1), pp. 6069. Date of Electronic Publication: 2022 Oct 14.