Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability

Autor: As, Fleisher, Manel Esteller, Wang S, Tamura G, Suzuki H, Yin J, Tt, Zou, Jm, Abraham, Kong D, Kn, Smolinski, Yq, Shi, Mg, Rhyu, Sm, Powell, Sp, James, Kt, Wilson, Jg, Herman, Sj, Meltzer

Publikováno v: Europe PubMed Central

Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than does any other type of sporadic human cancer. The reasons for this high frequency of MSI are not yet known. In contrast to endometrial and colorectal carcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c4fd30a2748cf8c594078b0d5375ab91
https://pubmed.ncbi.nlm.nih.gov/10070967

Response to Viveiros et al: A call for tribal engagement and community partnerships.

Autor: Wilson KT; University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address: wils2669@umn.edu., Calac AJ; University of California San Diego School of Medicine, San Diego, California., Shukis M; University of Cincinnati College of Medicine, Cincinnati, Ohio., Kohn L; Department of Dermatology, University of Colorado, Aurora, Colorado; Centers for American Indian and Alaska Native Health, Colorado School of Public Health, Aurora, Colorado.

Publikováno v: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

Data-driven nucleus subclassification on colon hematoxylin and eosin using style-transferred digital pathology.

Autor: Remedios LW; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States., Bao S; Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, Tennessee, United States., Remedios SW; Johns Hopkins University, Department of Computer Science, Baltimore, Maryland, United States.; National Institutes of Health, Department of Radiology and Imaging Sciences, Bethesda, Maryland, United States., Lee HH; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States., Cai LY; Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States., Li T; Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States., Deng R; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States., Newlin NR; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States., Saunders AM; Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, Tennessee, United States., Cui C; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States., Li J; Vanderbilt University Medical Center, Department of Biostatistics, Nashville, Tennessee, United States., Liu Q; Vanderbilt University Medical Center, Department of Biostatistics, Nashville, Tennessee, United States.; Vanderbilt University Medical Center, Center for Quantitative Sciences, Nashville, Tennessee, United States., Lau KS; Vanderbilt University Medical Center, Center for Quantitative Sciences, Nashville, Tennessee, United States.; Vanderbilt University Medical Center, Epithelial Biology Center, Nashville, Tennessee, United States.; Vanderbilt University School of Medicine, Department of Cell and Developmental Biology, Nashville, Tennessee, United States., Roland JT; Vanderbilt University Medical Center, Epithelial Biology Center, Nashville, Tennessee, United States., Washington MK; Vanderbilt University Medical Center, Department of Pathology, Microbiology, and Immunology, Nashville, Tennessee, United States., Coburn LA; Vanderbilt University Medical Center, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Nashville, Tennessee, United States.; Vanderbilt University Medical Center, Vanderbilt Center for Mucosal Inflammation and Cancer, Nashville, Tennessee, United States.; Vanderbilt University School of Medicine, Program in Cancer Biology, Nashville, Tennessee, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States., Wilson KT; Vanderbilt University Medical Center, Department of Pathology, Microbiology, and Immunology, Nashville, Tennessee, United States.; Vanderbilt University Medical Center, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Nashville, Tennessee, United States.; Vanderbilt University Medical Center, Vanderbilt Center for Mucosal Inflammation and Cancer, Nashville, Tennessee, United States.; Vanderbilt University School of Medicine, Program in Cancer Biology, Nashville, Tennessee, United States.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, United States., Huo Y; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States.; Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, Tennessee, United States., Landman BA; Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States.; Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, Tennessee, United States.; Vanderbilt University, Department of Biomedical Engineering, Nashville, Tennessee, United States.

Publikováno v: Journal of medical imaging (Bellingham, Wash.) [J Med Imaging (Bellingham)] 2024 Nov; Vol. 11 (6), pp. 067501. Date of Electronic Publication: 2024 Nov 05.

Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.

Autor: Li J; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Simmons AJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Hawkins CV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chiron S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ramirez-Solano MA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Tasneem N; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Kaur H; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Xu Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Revetta F; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Vega PN; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Bao S; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA., Cui C; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Tyree RN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raber LW; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Conner AN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pilat JM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jacobse J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McNamara KM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Allaman MM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raffa GA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gobert AP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Asim M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Goettel JA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Choksi YA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Beaulieu DB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dalal RL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Horst SN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pabla BS; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Roland JT; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Scoville EA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Schwartz DA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Washington MK; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Shyr Y; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Wilson KT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. keith.wilson@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. keith.wilson@vumc.org., Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. lori.coburn@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. lori.coburn@vumc.org., Lau KS; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu., Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7204. Date of Electronic Publication: 2024 Aug 22.

Cross-scale multi-instance learning for pathological image diagnosis.

Autor: Deng R; Vanderbilt University, Nashville, TN 37215, USA., Cui C; Vanderbilt University, Nashville, TN 37215, USA., Remedios LW; Vanderbilt University, Nashville, TN 37215, USA., Bao S; Vanderbilt University, Nashville, TN 37215, USA., Womick RM; The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Chiron S; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Li J; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Roland JT; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lau KS; Vanderbilt University, Nashville, TN 37215, USA., Liu Q; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Wilson KT; Vanderbilt University Medical Center, Nashville, TN 37232, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA., Wang Y; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Coburn LA; Vanderbilt University Medical Center, Nashville, TN 37232, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA., Landman BA; Vanderbilt University, Nashville, TN 37215, USA; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Huo Y; Vanderbilt University, Nashville, TN 37215, USA. Electronic address: yuankai.huo@vanderbilt.edu.

Publikováno v: Medical image analysis [Med Image Anal] 2024 May; Vol. 94, pp. 103124. Date of Electronic Publication: 2024 Feb 27.