Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kshitij Verma"'
Publikováno v:
Molecules, Vol 25, Iss 22, p 5390 (2020)
Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated in the body by various endogenous and exogenous systems. The overproduction of free radicals is known to cause several chronic disea
Externí odkaz:
https://doaj.org/article/fa4363cad3b348b89818b410804a7899
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542f6b08bf08d3952e982df2f5645c06
https://doi.org/10.1158/1535-7163.c.6538467.v1
https://doi.org/10.1158/1535-7163.c.6538467.v1
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S6: Co-treatments of KV-37 with ENZ do not exert synergistic cytotoxic effects in LNCaP and 22Rv1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6867cb0a6a514123cea6f3a72d4964f
https://doi.org/10.1158/1535-7163.22506675
https://doi.org/10.1158/1535-7163.22506675
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S4 & S5: S4: Baccharin does not exert cytotoxicity on prostate cancer cell lines. S5: Percentage cell viability of ENZ at indicated time points across cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35db9202f2b38d1c3f0fec77c739931a
https://doi.org/10.1158/1535-7163.22506681.v1
https://doi.org/10.1158/1535-7163.22506681.v1
Autor:
Wayne J. Fairbrother, Sayumi Yamazoe, Ingrid E. Wertz, Nicole Blaquiere, Steven T. Staben, Willem den Besten, Domagoj Vucic, Kebing Yu, Melinda M. Mulvihill, Elizabeth Helgason, Erin C. Dueber, Kshitij Verma, Wilson Phung, Tatiana Goncharov, Sumit Prakash, Anita Izrael-Tomasevic
Publikováno v:
Journal of the American Chemical Society. 143:10571-10575
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small molecules could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small molecules was modified to append a nucleophilic primary amine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f843d2ea05f107972c8984483e27ea
https://doi.org/10.1021/jacs.1c05269
https://doi.org/10.1021/jacs.1c05269
Autor:
Michael Giles, Lucy Reynales, Avinash Jayaraman, Omer Kaplan, Kshitij Verma, Katharina Wiest, Kim A. Hoffman, Dongseok Choi, Mark McGovern, Dennis McCarty
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1347f104ea21a2a8042ec23fece09cfe
https://doi.org/10.2139/ssrn.4258702
https://doi.org/10.2139/ssrn.4258702
Autor:
Trevor M. Penning, Sanjay K. Srivastava, Tianzhu Zang, Paul C. Trippier, Nehal Gupta, Phumvadee Wangtrakluldee, Kshitij Verma
Publikováno v:
Molecular Cancer Therapeutics. 17:1833-1845
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d711757ae565e2155eb58e0b23df1a
https://doi.org/10.1158/1535-7163.mct-17-1023
https://doi.org/10.1158/1535-7163.mct-17-1023
Publikováno v:
ICCCNT
We introduce a novel approach to calculate the semantic similarity between sentences. Unlike conventional approaches, we leverage dependency grammar representations of the sentences and semantic word similarity methods to find the semantic similarity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73cc79194a1c6b8849e0b9422d58b472
https://doi.org/10.1109/icccnt45670.2019.8944671
https://doi.org/10.1109/icccnt45670.2019.8944671
Publikováno v:
Journal of medicinal chemistry. 62(7)
Aldo–keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9α,11β-prostaglandin (PG) F(2α) and PGF(2α) prostanoids that sustain the growth of myeloid precursors in the bone marrow. The enzyme is overexpressed in acute myeloid leukemia (AML) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2949a47bb55577f5752a7f707db3a60
https://pubmed.ncbi.nlm.nih.gov/30836001
https://pubmed.ncbi.nlm.nih.gov/30836001
Publikováno v:
ACS Medicinal Chemistry Letters. 7:774-779
We report the design, synthesis, and evaluation of potent and selective inhibitors of aldo-keto reductase 1C3 (AKR1C3), an important enzyme in the regulatory pathway controlling proliferation, differentiation, and apoptosis in myeloid cells. Combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7230b13cf2940e7fd649f0aebd78e1e5
https://doi.org/10.1021/acsmedchemlett.6b00163
https://doi.org/10.1021/acsmedchemlett.6b00163