Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kshiti H Dholakia"'
Autor:
Xin Xu, Siyue Wang, Julie A Tomolonis, Kshiti H Dholakia, Chunchao Zhang, Linjie Guo, Amy N Courtney, Julien Balzeau, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Tumor progression and resistance to therapy in children with neuroblastoma (NB), a common childhood cancer, are often associated with infiltration of monocytes and macrophages that produce inflammatory cytokines. However, the mechanism by
Externí odkaz:
https://doaj.org/article/6cc8bf94fbce43958f5abec2305331a6
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
Application of Bliss independence to test for synergy effect of TKI combination treatment in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4903139a78bc221e2202f3b12db12a51
https://doi.org/10.1158/1535-7163.22521927.v1
https://doi.org/10.1158/1535-7163.22521927.v1
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
MET-targeted therapies are clinically effective in MET-amplified and MET exon 14 deletion mutant (METex14) non–small cell lung cancers (NSCLCs), but their efficacy is limited by the development of drug resistance. Structurally distinct MET tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb636b4d303925dcf3349ce844b41a8
https://doi.org/10.1158/1535-7163.c.6543231.v1
https://doi.org/10.1158/1535-7163.c.6543231.v1
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
Supplementary Figures S1-3; Supplementary Tables S1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53186772e45cde82b5f37f176dc5fdfc
https://doi.org/10.1158/1535-7163.22521930.v1
https://doi.org/10.1158/1535-7163.22521930.v1
Autor:
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, Biagio Ricciuti
Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e908ecdb4bf36d5ab7cc98336d10d7d
https://doi.org/10.1158/1078-0432.22484111.v1
https://doi.org/10.1158/1078-0432.22484111.v1
Autor:
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, Biagio Ricciuti
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a622d7dd524d9e4c7db5d7f6e4ccfdc
https://doi.org/10.1158/1078-0432.c.6531326
https://doi.org/10.1158/1078-0432.c.6531326
Autor:
Julie A Tomolonis, Xin Xu, Kshiti H Dholakia, Chunchao Zhang, Linjie Guo, Amy N Courtney, Siyue Wang, Julien Balzeau, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e005478
BackgroundTumor progression and resistance to therapy in children with neuroblastoma (NB), a common childhood cancer, are often associated with infiltration of monocytes and macrophages that produce inflammatory cytokines. However, the mechanism by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede23e2d8f501b58e1d8d0b6b53a13ed
https://doi.org/10.1136/jitc-2022-005478
https://doi.org/10.1136/jitc-2022-005478
Autor:
Biagio Ricciuti, Jieun Son, Jeffrey J. Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M. Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J. Redig, Jens Köhler, Kshiti H. Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C. Gokhale, Mark M. Awad, Pasi A. Jänne, Chiara Ambrogio
Publikováno v:
Clinical Cancer Research
Purpose:Activating missense mutations of KRAS are the most frequent oncogenic driver events in lung adenocarcinoma (LUAD). However, KRAS isoforms are highly heterogeneous, and data on the potential isoform-dependent therapeutic vulnerabilities are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26aaf3a21c7123d8632c8ec31fa75511
http://hdl.handle.net/2318/1855101
http://hdl.handle.net/2318/1855101
Autor:
Pınar Özden, Eser, Raymond M, Paranal, Jieun, Son, Elena, Ivanova, Yanan, Kuang, Heidi M, Haikala, Ciric, To, Jeffrey J, Okoro, Kshiti H, Dholakia, Jihyun, Choi, Yoonji, Eum, Atsuko, Ogino, Pavlos, Missios, Dalia, Ercan, Man, Xu, Michael J, Poitras, Stephen, Wang, Kenneth, Ngo, Michael, Dills, Masahiko, Yanagita, Timothy, Lopez, Mika, Lin, Jeanelle, Tsai, Nicolas, Floch, Emily S, Chambers, Jennifer, Heng, Rana, Anjum, Alison D, Santucci, Kesi, Michael, Alwin G, Schuller, Darren, Cross, Paul D, Smith, Geoffrey R, Oxnard, David A, Barbie, Lynette M, Sholl, Magda, Bahcall, Sangeetha, Palakurthi, Prafulla C, Gokhale, Cloud P, Paweletz, George Q, Daley, Pasi A, Jänne
Publikováno v:
Science translational medicine
The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in EGFR-mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance occurs through amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22efb640067814269983395f20ecc3cd
https://pubmed.ncbi.nlm.nih.gov/34516823
https://pubmed.ncbi.nlm.nih.gov/34516823