Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Kshipra Singh"'
Autor:
Kshipra Singh, Alain P. Gobert, Lori A. Coburn, Daniel P. Barry, Margaret Allaman, Mohammad Asim, Paula B. Luis, Claus Schneider, Ginger L. Milne, Helen H. Boone, Meghan H. Shilts, M. Kay Washington, Suman R. Das, M. Blanca Piazuelo, Keith T. Wilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
There is great interest in safe and effective alternative therapies that could benefit patients with inflammatory bowel diseases (IBD). L-arginine (Arg) is a semi-essential amino acid with a variety of physiological effects. In this context, our aim
Externí odkaz:
https://doaj.org/article/7155bb0c4fa443f19d5c19bdc86dbe65
Autor:
Alain P. Gobert, Nicole T. Al-Greene, Kshipra Singh, Lori A. Coburn, Johanna C. Sierra, Thomas G. Verriere, Paula B. Luis, Claus Schneider, Mohammad Asim, Margaret M. Allaman, Daniel P. Barry, John L. Cleveland, Christina E. Destefano Shields, Robert A. Casero, M. Kay Washington, M. Blanca Piazuelo, Keith T. Wilson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine. The enzy
Externí odkaz:
https://doaj.org/article/740a25b20113470485090afbaa34d653
Autor:
Kshipra Singh, Nicole T Al-Greene, Thomas G Verriere, Lori A Coburn, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Dana M Hardbower, Alberto G Delgado, M Blanca Piazuelo, Bruce A Vallance, Alain P Gobert, Keith T Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005984 (2016)
Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens. We assessed the role of SLC7A2 in murine infection with Citrobacter
Externí odkaz:
https://doaj.org/article/dde25832be474145b30f534c31096627
Autor:
Lori A Coburn, Sara N Horst, Rupesh Chaturvedi, Caroline T Brown, Margaret M Allaman, Brooks P Scull, Kshipra Singh, M Blanca Piazuelo, Maithili V Chitnavis, Mallary E Hodges, Michael J Rosen, Christopher S Williams, James C Slaughter, Dawn B Beaulieu, David A Schwartz, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82300 (2013)
Accurate and high-throughput technologies are needed for identification of new therapeutic targets and for optimizing therapy in inflammatory bowel disease. Our aim was to assess multi-analyte protein-based assays of cytokines/chemokines using Lumine
Externí odkaz:
https://doaj.org/article/d4d7f74ea15f44989f08172ba757ae3f
Autor:
Caitlyn W Barrett, Kshipra Singh, Amy K Motley, Mary K Lintel, Elena Matafonova, Amber M Bradley, Wei Ning, Shenika V Poindexter, Bobak Parang, Vishruth K Reddy, Rupesh Chaturvedi, Barbara M Fingleton, Mary K Washington, Keith T Wilson, Sean S Davies, Kristina E Hill, Raymond F Burk, Christopher S Williams
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67845 (2013)
Selenium (Se) is an essential micronutrient that exerts its functions via selenoproteins. Little is known about the role of Se in inflammatory bowel disease (IBD). Epidemiological studies have inversely correlated nutritional Se status with IBD sever
Externí odkaz:
https://doaj.org/article/ef779befc8d54e5d9a33d60fef5898e8
Autor:
Lori A Coburn, Xue Gong, Kshipra Singh, Mohammad Asim, Brooks P Scull, Margaret M Allaman, Christopher S Williams, Michael J Rosen, M Kay Washington, Daniel P Barry, M Blanca Piazuelo, Robert A Casero, Rupesh Chaturvedi, Zhongming Zhao, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33546 (2012)
Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC), results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies are needed. One candidate is the semi-essential amino acid,
Externí odkaz:
https://doaj.org/article/533feca6ab3b4bd2a33c8baf8209e8b6
Autor:
Daniel P Barry, Mohammad Asim, David A Leiman, Thibaut de Sablet, Kshipra Singh, Robert A Casero, Rupesh Chaturvedi, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17510 (2011)
Helicobacter pylori infects half the world's population, and carriage is lifelong without antibiotic therapy. Current regimens prescribed to prevent infection-associated diseases such as gastroduodenal ulcers and gastric cancer can be thwarted by ant
Externí odkaz:
https://doaj.org/article/caf3d875014246a289923380d70287b6
Autor:
Daniel P Barry, Mohammad Asim, Brooks P Scull, M Blanca Piazuelo, Thibaut de Sablet, Nuruddeen D Lewis, Lori A Coburn, Kshipra Singh, Lesley G Ellies, Alain P Gobert, Rupesh Chaturvedi, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29046 (2011)
Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants
Externí odkaz:
https://doaj.org/article/09ba87fccc7840d89038169ee39687b0
Autor:
M. Blanca Piazuelo, Keith T. Wilson, Michael J. Greer, Ali Nazmi, Kathleen G. McClanahan, Danyvid Olivares-Villagómez, Kristen L. Hoek, Kshipra Singh
Publikováno v:
Mucosal immunology
CD4+ T cell activation and differentiation are important events that set the stage for proper immune responses. Many factors are involved in the activation and differentiation of T cells, and these events are tightly controlled to prevent unwanted an
Autor:
Daniel P. Barry, Keith T. Wilson, Thaddeus M. Smith, Mohammad Asim, M. Kay Washington, Alain P. Gobert, Lori A. Coburn, Yvonne L. Latour, Johanna C. Sierra, Paula B. Luis, Jordan L. Finley, Shilin Zhao, M. Blanca Piazuelo, Kshipra Singh, Margaret M. Allaman, Alberto G. Delgado, Kara M. McNamara, Claus Schneider
Publikováno v:
Gastroenterology
BACKGROUND & AIMS Because inflammatory bowel disease is increasing worldwide and can lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown that spermine oxidase (SMOX), which generates spermidine (Spd), regulates col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd86e98aa8c3ea234c8a9950e011ad4
https://europepmc.org/articles/PMC8881368/
https://europepmc.org/articles/PMC8881368/