Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kshipra S. Karnik"'
Autor:
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate
Publikováno v:
Journal of Taibah University for Science, Vol 13, Iss 1, Pp 678-686 (2019)
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents. We desire to state the advancement and execution of a methodol
Externí odkaz:
https://doaj.org/article/b3a7bc25b77d4e1497c428a1864ce615
Autor:
Deepak K. Lokwani, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje, Julio A. Seijas
Publikováno v:
Molecules, Vol 25, Iss 7, p 1622 (2020)
Metabolism is one of the prime reasons where most of drugs fail to accomplish their clinical trials. The enzyme CYP3A4, which belongs to the superfamily of cytochrome P450 enzymes (CYP), helps in the metabolism of a large number of drugs in the body.
Externí odkaz:
https://doaj.org/article/7a0f2c6ba2d74b82a8c00f9678836de1
Autor:
Shailee V. Tiwari, Julio A. Seijas, Maria Pilar Vazquez-Tato, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje
Publikováno v:
Molecules, Vol 23, Iss 2, p 440 (2018)
Herein, we report an environmentally friendly, rapid, and convenient ionic liquid ([Et3NH][HSO4])-promoted facile synthesis of ethyl 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives
Externí odkaz:
https://doaj.org/article/69cbc475ae444a56a471a6ccebf06ca1
Autor:
Shailee V. Tiwari, Julio A. Seijas, Maria Pilar Vazquez-Tato, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje
Publikováno v:
Molecules, Vol 22, Iss 7, p 1172 (2017)
The work reports the synthesis under solvent-free condition using the ionic liquid [Et3NH][HSO4] as a catalyst of fifteen novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)-methyl)-4-hydroxy-2H-chromen-2-onederivatives 4a–o as potential antim
Externí odkaz:
https://doaj.org/article/cb2d96bef405491a865871b2fb926e32
Publikováno v:
Letters in Drug Design & Discovery. 20:1204-1218
Background: Mutations occurring in the epidermal growth factor receptor of the tyrosine kinase family concerned with non-small cell lung cancer have been specifically targeted. Objectives: The library design and R-group enhancement technique have bee
Publikováno v:
Medicinal Chemistry Research. 31:1500-1516
Autor:
Kshipra S. Karnik, Aniket P. Sarkate, Deepak K. Lokwani, Shailee V. Tiwari, Rajaram Azad, Pravin S. Wakte
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-15
Targeting kinases with oncogenic driver mutations in malignancies with allosteric kinase inhibitors is a promising new treatment technique. EGFR inhibitors targeting the L858R/T790M/C797S mutation bearing thiazolidine-4-one scaffold were discovered,
Publikováno v:
Letters in Drug Design & Discovery. 19
Background: The epidermal growth factor receptor of the tyrosine kinase family has been largely targeted in mutations associated with non-small cell lung cancer. EGFR inhibitors have been produced that bind allosterically to the C797S mutant EGFR enz
Autor:
Prasad V.L.S. Burra, Deepak K. Lokwani, Kshipra S. Karnik, Ishudeep Singh Narula, Pravin S. Wakte, Aniket P. Sarkate
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:5376-5398
The mutations concerned with non-small cell lung cancer involving epidermal growth factor receptor of tyrosine kinase family have primarily targeted. EGFR inhibitors binding allosterically to C797S mutant EGFR enzyme have been developed. Here, databa
Autor:
Vaishnavi S. Jambhorkar, Aishwarya P. Rajhans, Kshipra S. Karnik, Ishudeep Singh Narula, A. L. Khandare, B. D. Kale, Aniket P. Sarkate, D. S. Gavane
Publikováno v:
Russian Journal of Organic Chemistry. 56:1300-1303
Diaryl sulfides have been synthesized in moderate to excellent yield by S-arylation of arenethiols with arylboronic acids using copper slag as a catalyst. Copper slag is a by-product obtained from smelting and refining of copper. Conventional heating