Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kseniya, Khamina"'
Autor:
Jane I. Grove, Camilla Stephens, M. Isabel Lucena, Raúl J. Andrade, Sabine Weber, Alexander Gerbes, Einar S. Bjornsson, Guido Stirnimann, Ann K. Daly, Matthias Hackl, Kseniya Khamina-Kotisch, Jose J. G. Marin, Maria J. Monte, Sara A. Paciga, Melanie Lingaya, Shiva S. Forootan, Christopher E. P. Goldring, Oliver Poetz, Rudolf Lombaard, Alexandra Stege, Helgi K. Bjorrnsson, Mercedes Robles-Diaz, Dingzhou Li, Thi Dong Binh Tran, Shashi K. Ramaiah, Sophia L. Samodelov, Gerd A. Kullak-Ublick, Guruprasad P. Aithal, on behalf of the TransBioLine consortium
Publikováno v:
Diagnostic and Prognostic Research, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract A lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a challenge in clinical practice. The Innovative Medicines Initiative’s TransBioLine consor
Externí odkaz:
https://doaj.org/article/01c9031ea63844faa64609c76d355eda
Autor:
Mark Smyth, Kseniya Khamina, Alexandra Popa, Venugopal Gudipati, Benedikt Agerer, Alexander Lercher, Lindsay Kosack, Lukas Endler, Hatoon Baazim, Csilla Viczenczova, Johannes B. Huppa, Andreas Bergthaler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cytotoxic T lymphocytes (CTLs) represent key immune effectors of the host response against chronic viruses, due to their cytotoxic response to virus-infected cells. In response to this selection pressure, viruses may accumulate escape mutations that
Externí odkaz:
https://doaj.org/article/189e3d41775e41b897b0e95c658d10e2
Autor:
Alexandra Franziska Gülich, Ramona Rica, Caroline Tizian, Csilla Viczenczova, Kseniya Khamina, Thomas Faux, Daniela Hainberger, Thomas Penz, Remy Bosselut, Christoph Bock, Asta Laiho, Laura L. Elo, Andreas Bergthaler, Wilfried Ellmeier, Shinya Sakaguchi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The BTB zinc finger transcription factor MAZR (also known as PATZ1) controls, partially in synergy with the transcription factor Runx3, the development of CD8 lineage T cells. Here we explored the role of MAZR as well as combined activities of MAZR/R
Externí odkaz:
https://doaj.org/article/4b233b2a316e48e78a3000b1d9d5c593
Autor:
Kseniya Khamina, Andreas B. Diendorfer, Susanna Skalicky, Moritz Weigl, Marianne Pultar, Teresa L. Krammer, Catharine Aquino Fournier, Amy L. Schofield, Carolin Otto, Aaron Thomas Smith, Nina Buchtele, Christian Schoergenhofer, Bernd Jilma, Bernhard J. H. Frank, Jochen G. Hofstaetter, Regina Grillari, Johannes Grillari, Klemens Ruprecht, Christopher E. Goldring, Hubert Rehrauer, Warren E. Glaab, Matthias Hackl
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1226 (2022)
The plasma levels of tissue-specific microRNAs can be used as diagnostic, disease severity and prognostic biomarkers for chronic and acute diseases and drug-induced injury. Thereby, the combination of diverse microRNAs into biomarker signatures using
Externí odkaz:
https://doaj.org/article/2417266615174c1686661edf0937c205
Autor:
Dane M. Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L. Nutt, Gordon K. Smyth, Anne K. Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T. Belz, Rhys S. Allan
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3311-3321 (2016)
How functionally diverse populations of pathogen-specific killer T cells are generated during an immune response remains unclear. Here, we propose that fine-tuning of CD8αβ co-receptor levels via histone acetylation plays a role in lineage fate. We
Externí odkaz:
https://doaj.org/article/c3c57588973b4e739d9d3cceeb66394a
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
Autor:
Kseniya Khamina, Alexander Lercher, Michael Caldera, Christopher Schliehe, Bojan Vilagos, Mehmet Sahin, Lindsay Kosack, Anannya Bhattacharya, Peter Májek, Alexey Stukalov, Roberto Sacco, Leo C James, Daniel D Pinschewer, Keiryn L Bennett, Jörg Menche, Andreas Bergthaler
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006758 (2017)
RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic infection.
Externí odkaz:
https://doaj.org/article/61f6526a55ef46658467aab0a567e0fd
Autor:
Clemens Gutmann, Adam Nabeebaccus, Adrian Hayday, Matthew Fish, Kevin O'Gallagher, Francesca Trovato, Salvatore Napoli, Georg Auzinger, Lukas E Schmidt, Mark J. W. McPhail, Matthias Hackl, Andreas B. Diendorfer, Sean A. Burnap, Salma F Mujib, Blair Merrick, Barnaby Sanderson, Ajay M. Shah, Ludwig Traby, Christian Cassel, Roman Roy, Manuel Mayr, Manu Shankar-Hari, Jonathan D. Edgeworth, Konstantinos Theofilatos, Sabine Eichinger, Kseniya Khamina
Publikováno v:
Gutmann, C, Khamina, K, Theofilatos, K, Diendorfer, A B, Burnap, S A, Nabeebaccus, A, Fish, M, McPhail, M J W, O'Gallagher, K, Schmidt, L E, Cassel, C, Auzinger, G, Napoli, S, Mujib, S F, Trovato, F, Sanderson, B, Merrick, B, Roy, R, Edgeworth, J D, Shah, A M, Hayday, A C, Traby, L, Hackl, M, Eichinger, S, Shankar-Hari, M & Mayr, M 2022, ' Association of cardiometabolic microRNAs with COVID-19 severity and mortality ', Cardiovascular Research, vol. 118, no. 2, pp. 461-474 . https://doi.org/10.1093/cvr/cvab338
Cardiovascular research
Cardiovascular Research
Gutmann, C, Khamina, K, Theofilatos, K, Diendorfer, A B, Burnap, S A, Nabeebaccus, A, Fish, M, McPhail, M J W, O'Gallagher, K, Schmidt, L E, Cassel, C, Auzinger, G, Napoli, S, Mujib, S F, Trovato, F, Sanderson, B, Merrick, B, Roy, R, Edgeworth, J D, Shah, A M, Hayday, A C, Traby, L, Hackl, M, Eichinger, S, Shankar-Hari, M & Mayr, M 2021, ' Association of cardiometabolic microRNAs with COVID-19 severity and mortality ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab338
Cardiovascular research
Cardiovascular Research
Gutmann, C, Khamina, K, Theofilatos, K, Diendorfer, A B, Burnap, S A, Nabeebaccus, A, Fish, M, McPhail, M J W, O'Gallagher, K, Schmidt, L E, Cassel, C, Auzinger, G, Napoli, S, Mujib, S F, Trovato, F, Sanderson, B, Merrick, B, Roy, R, Edgeworth, J D, Shah, A M, Hayday, A C, Traby, L, Hackl, M, Eichinger, S, Shankar-Hari, M & Mayr, M 2021, ' Association of cardiometabolic microRNAs with COVID-19 severity and mortality ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab338
Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage. MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to determine the association of circulating miRNAs with COVID-19 severity and 28 day intensive car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee058733d1ff5ea0db0e48b3863079e
Publikováno v:
F1000Reserach
In contrast to traditional methods like real-time polymerase chain reaction, next-generation sequencing (NGS), and especially small RNA-seq, enables the untargeted investigation of the whole small RNAome, including microRNAs (miRNAs) but also a multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73ee97f2c81c738c07a33f66a004c79
Autor:
Alexandra Franziska, Gülich, Ramona, Rica, Caroline, Tizian, Csilla, Viczenczova, Kseniya, Khamina, Thomas, Faux, Daniela, Hainberger, Thomas, Penz, Remy, Bosselut, Christoph, Bock, Asta, Laiho, Laura L, Elo, Andreas, Bergthaler, Wilfried, Ellmeier, Shinya, Sakaguchi
Publikováno v:
Frontiers in Immunology
The BTB zinc finger transcription factor MAZR (also known as PATZ1) controls, partially in synergy with the transcription factor Runx3, the development of CD8 lineage T cells. Here we explored the role of MAZR as well as combined activities of MAZR/R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5965cd6b36c4ed3131e42537d2f5c249
https://pubmed.ncbi.nlm.nih.gov/33815354
https://pubmed.ncbi.nlm.nih.gov/33815354
Autor:
Keiryn L. Bennett, Gregory M. Woods, Alexandra Popa, David A. Rosa, Ji Sung Park, Hannah V. Siddle, Christoph Bock, Patrick T. Gunning, Gary Tin, Andreas Bergthaler, Anna Orlova, Lindsay Kosack, Bettina Wingelhofer, Anna Ringler, Kseniya Khamina, Stefan Kubicek, Elizabeth P. Murchison, Benedikt Agerer, Peter Májek, Katja Parapatics, Richard Moriggl, Mark J. Smyth, Johanna Klughammer, Bojan Vilagos, Alexander Lercher, Hatoon Baazim, Elvin D. de Araujo, Siawash Ahmar
Publikováno v:
Cancer Cell
Summary The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular underpinnings of this transmissible cancer, we combined pharmacological screens with an inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7956ef0b526be60c90a247b0e646665
https://eprints.soton.ac.uk/427459/
https://eprints.soton.ac.uk/427459/