Výsledky vyhledávání - "Ksenia Musaelyan"

Akademický článek

Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation

Autor: Ksenia Musaelyan, Martin Egeland, Cathy Fernandes, Carmine M. Pariante, Patricia A. Zunszain, Sandrine Thuret

Publikováno v: Neural Plasticity, Vol 2014 (2014)

The immune system plays an important role in the communication between the human body and the environment, in early development as well as in adulthood. Per se, research has shown that factors such as maternal stress and nutrition as well as maternal

Externí odkaz: https://doaj.org/article/d2766a115b894f34b1c99575d1243378

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Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice

Autor: Sandrine Thuret, Andrea Du Preez, Inez Eiben, Ksenia Musaelyan, Patricia A. Zunszain, Diletta Onorato, Martin Egeland, Carmine M. Pariante, Cathy Fernandes

Publikováno v: Brain, Behavior, and Immunity. 91:24-47

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and translatable models for studying the neurobiological basis of major depression. Although the model currently has multiple advantages, it does not entirely follow th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5651fc22a929fab54545fcde21d5a968
https://doi.org/10.1016/j.bbi.2020.07.015

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Evaluation of Acute Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Plasma Levels in Traumatic Brain Injury Patients with and without Intracranial Lesions

Autor: Peter Biberthaler, Ksenia Musaelyan, Sandro Krieg, Bernhard Meyer, Herbert Stimmer, Julian Zapf, Francesca von Matthey, Raj Chandran, Jaime A. Marino, Gangamani Beligere, Markus Hoffmann, Hongwei Zhang, Saul A. Datwyler, Beth McQuiston

Publikováno v: Neurotrauma Reports

This pilot study aimed to evaluate the association of plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1), glial fibrillary acidic protein (GFAP), and S100 calcium-binding protein B (S100B) with intracranial abnormalities visible on a computed tomograp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d348111c0ed60cd0368f5ff1edb32e1f
https://pubmed.ncbi.nlm.nih.gov/35018363

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The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations

Autor: Patricia A. Zunszain, Thomas Law, Yau M Lim, Martin Egeland, Abdul Hye, Sandrine Thuret, Carmine M. Pariante, Cathy Fernandes, Paola Eiben, Ksenia Musaelyan, Andrea Du Preez, Diletta Onorato

Publikováno v: Translational Psychiatry, Vol 10, Iss 1, Pp 1-17 (2020)
Translational Psychiatry

Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- and depressive-like behaviour in rodents. However, previous studies have not discriminated between the effect(s) of different types of stress on these beha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe93676254e0a02a37a064d26393610
https://doi.org/10.1038/s41398-020-01000-3

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Glucocorticoids prime the inflammatory response of human hippocampal cells through up-regulation of inflammatory pathways

Autor: Alessandra Borsini, Ksenia Musaelyan, Luis M. Tojo, Natalia Bakunina, Nicola Lopizzo, Particia A. Zunszain, Mark Abie Horowitz, Carmine M. Pariante, Annamaria Cattaneo, Nadia Cattane

Publikováno v: Horowitz, M A, Cattaneo, A, Cattane, N, Lopizzo, N, Tojo, L, Bakunina, N, Musaelyan, K, Borsini, A, Zunszain, P A & Pariante, C M 2020, ' Glucocorticoids prime the inflammatory response of human hippocampal cells through up-regulation of inflammatory pathways ', Brain, Behavior, and Immunity, vol. 87, no. 0, pp. 777-794 . https://doi.org/10.1016/j.bbi.2020.03.012

Increased pro-inflammatory cytokines and an overactive hypothalamic-pituitary-adrenal (HPA) axis have both been implicated in the pathogenesis of depression. However, these explanations appear contradictory because glucocorticoids are well recognised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aeb62f9372281515b3519aa5988c65
https://pubmed.ncbi.nlm.nih.gov/32194233

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Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone

Autor: Francis G. Szele, Abeer R Al-Shammari, Ksenia Musaelyan, Sanjeev K. Bhardwaj, Lalit K. Srivastava

Publikováno v: NPJ Schizophrenia
npj Schizophrenia, Vol 4, Iss 1, Pp 1-11 (2018)

Schizophrenia is a neurodevelopmental disorder likely caused by environmental and genetic risk factors but functional interactions between the risk factors are unclear. We tested the hypothesis that dysbindin-1 (Dtnbp1) gene mutation combined with po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a29d650614935cc14dbdff56c9f2fc
http://ora.ox.ac.uk/objects/uuid:

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Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation

Autor: S. E. Aldridge, Carmine M. Pariante, Sandrine Thuret, Cathy Fernandes, Ksenia Musaelyan, Martin Egeland, Andrea Du Preez, Patricia A. Zunszain

Publikováno v: Musaelyan, K, Aldridge, S E, Du Preez, A, Egeland, M T L, Zunszain, P A, Pariante, C M, Thuret, S & Fernandes, C 2017, ' Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation ', Journal of Psychopharmacology, vol. 32, no. 2, pp. 236-247 . https://doi.org/10.1177/0269881117746902

Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic lipopolysacch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d25a795998f8238014fd006e6302b55
https://pubmed.ncbi.nlm.nih.gov/29338496

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Modulation of Adult Hippocampal Neurogenesis by Early-Life Environmental Challenges Triggering Immune Activation

Autor: Carmine M. Pariante, Sandrine Thuret, Cathy Fernandes, Patricia A. Zunszain, Martin Egeland, Ksenia Musaelyan

Publikováno v: Neural Plasticity, Vol 2014 (2014)
Neural Plasticity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8314de00971646d5331d8d80104ab53
https://doi.org/10.1155/2014/194396

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Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis

Autor: Christoph Anacker, Ksenia Musaelyan, Rudolf Uher, Carmine M. Pariante, Sandrine Thuret, Massimo Gennarelli, Annamaria Cattaneo, Mark Abie Horowitz, Patricia A. Zunszain, Jack Price, Katherine E. Tansey, Alessia Luoni, Raffaella Molteni, Francesca Calabrese, Marco A. Riva

Publikováno v: Anacker, C, Cattaneo, A, Musaelyan, K, Zunszain, P, Horowitz, M, Molteni, R, Luoni, A, Calabrese, F, Tansey, K, Gennarelli, M, Thuret, S, Price, J, Uher, R, Riva, M A & Pariante, C 2013, ' Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis ', Proceedings of the National Academy of Sciences, vol. 110, no. 21, pp. 8708-8713 . https://doi.org/10.1073/pnas.1300886110

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify the glucocorticoid receptor (GR) target gene, serum- and glucocorticoid-inducible kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532a2d11d2afe0d3615d71a1d462866b
https://doi.org/10.1073/pnas.1300886110

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