Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.

Autor: Kawanami T; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Karki RG; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Cody E; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Liu Q; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Liang G; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ksander GM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Rigel DF; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Schiering N; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Gong Y; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Coppola GM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Iwaki Y; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Sun R; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Neubert A; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Fan L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ingles S; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., D'Arcy A; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Villard F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Ramage P; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Jeng AY; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Leung-Chu J; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Liu J; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Beil M; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Fu F; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Chen W; Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936-1080, United States., Cumin F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Wiesmann C; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland., Mogi M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Jan 27; Vol. 11 (2), pp. 188-194. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).

Structure of neprilysin in complex with the active metabolite of sacubitril.

Autor: Schiering N; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., D'Arcy A; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Villard F; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Ramage P; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Logel C; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Cumin F; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Ksander GM; Novartis Institutes for BioMedical Research Inc., 100 Technology Square, Cambridge, Massachusetts, 02139, United States., Wiesmann C; Novartis Institutes for BioMedical Research Inc., Fabrikstrasse 16, CH-4002 Basel, Switzerland., Karki RG; Novartis Institutes for BioMedical Research Inc., 100 Technology Square, Cambridge, Massachusetts, 02139, United States., Mogi M; Novartis Institutes for BioMedical Research Inc., 100 Technology Square, Cambridge, Massachusetts, 02139, United States.

Publikováno v: Scientific reports [Sci Rep] 2016 Jun 15; Vol. 6, pp. 27909. Date of Electronic Publication: 2016 Jun 15.

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Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.

Autor: Papillon JP; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Adams CM; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Hu QY; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Lou C; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Singh AK; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Zhang C; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Carvalho J; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Rajan S; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Amaral A; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Beil ME; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., Fu F; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., Gangl E; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Hu CW; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., Jeng AY; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., LaSala D; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., Liang G; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Logman M; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Maniara WM; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Rigel DF; ‡Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States., Smith SA; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States., Ksander GM; †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jun 11; Vol. 58 (11), pp. 4749-70. Date of Electronic Publication: 2015 May 21.

Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.

Autor: Ksander GM; Research Department, Novartis Pharmaceuticals Corporation, Summit, New Jersey 07901, USA., de Jesus R, Yuan A, Ghai RD, Trapani A, McMartin C, Bohacek R

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1997 Feb 14; Vol. 40 (4), pp. 495-505.