Abstract P2-16-20: Biomarkers to predict response to the CDK 4/6 inhibitor, palbociclib (PD 0332991) in a single-agent phase II trial in advanced breast cancer

Autor: Peter O'Dwyer, Michael Feldman, Paul J. Zhang, Kevin Fox, Maryann Gallagher, AS Clark, Keerthi Gogineni, Susan M. Domchek, AM DeMichele, Stephen M. Keefe, KS Tan, Daniel F. Heitjan, Priti Lal

Publikováno v: Cancer Research. 73:P2-16

Background: The Cyclin D1-CDK4/6 complex is critical in regulating the G1/S checkpoint and phosphorylation of retinoblastoma protein (Rb); palbociclib is a highly-selective CDK 4/6 inhibitor. CCND1, the gene encoding Cyclin D1, is amplified in 15% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbfdb1db326781f5a95d10a4dc6f3d6a
https://doi.org/10.1158/0008-5472.sabcs13-p2-16-20

Drought severity estimation under a changing climate

Autor: B G Rhodes, KS Tan

Publikováno v: Australasian Journal of Water Resources. 17:143-151

This paper describes an approach to estimate drought severity for drought response planning and urban water management considering the impacts of climate change and variability. Low flow frequency analysis was used to estimate drought severity (e.g.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e632006ba121acd1db98c495eb3ad75
https://doi.org/10.7158/w13-029.2013.17.2

Green pit viper antivenom from Thailand and Agkistrodon halys antivenom from China compared in treating Cryptelytrops albolabris envenomation of mice

Autor: Ht, Fung, Wh, Yung, Crow P, Kk, Lam, Kk, Ho, Ks, Tan, Sk, Lam, Ke Y, Grioni A, Of, Wong, Ades G, Cw, Kam, Man-Li Tse

Publikováno v: Europe PubMed Central

To compare the relative efficacy of the green pit viper antivenom from Thailand and Agkistrodon halys antivenom from China. DESIGN. In-vivo experimental study.A wildlife conservation organisation, a university, a poison information centre, and a regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::abea94ffa0c0122adac1d8d294ca1cbd
https://pubmed.ncbi.nlm.nih.gov/22302910

Carotid sinus reflex in response to hemorrhage

Autor: KS Tan, RM Schmidt, M Kumada, K Sagawa

Publikováno v: The American journal of physiology. 219(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cc1044756e6201c7228efdbaca33ba
https://pubmed.ncbi.nlm.nih.gov/5473121

Esophagectomy may have a role in stage IV esophageal adenocarcinoma.

Autor: Sewell M; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Toumbacaris N; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., Tan KS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., Bahadur N; Clinical & Translational Research Informatics, Memorial Sloan Kettering Cancer Center, New York, NY., Philip J; Clinical & Translational Research Informatics, Memorial Sloan Kettering Cancer Center, New York, NY., Shah NJ; Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY., Niederhausern A; Department of Translational Informatics, Memorial Sloan Kettering Cancer Center, New York, NY., Martinez CT; Clinical & Translational Research Informatics, Memorial Sloan Kettering Cancer Center, New York, NY., Zheng H; Clinical & Translational Research Informatics, Memorial Sloan Kettering Cancer Center, New York, NY., Boerner T; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Janjigian YY; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Maron SB; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Bott MJ; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Gray KD; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Park BJ; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Sihag S; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Jones DR; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Ku GY; Gastroenterology, Hepatology, and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Wu AJ; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY., Molena D; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: molenad@mskcc.org.

Publikováno v: The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.