Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Autor: Pfeffer I; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Brewitz L; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Krojer T; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK., Jensen SA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Kochan GT; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK., Kershaw NJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Hewitson KS; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., McNeill LA; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Kramer H; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK., Münzel M; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Hopkinson RJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Oppermann U; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.; NDORMS, Botnar Research Centre, University of Oxford, Old Road, Oxford, OX3 7LD, UK., Handford PA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., McDonough MA; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Oct 28; Vol. 10 (1), pp. 4910. Date of Electronic Publication: 2019 Oct 28.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Autor: Conejo-Garcia A; The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom., McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 15; Vol. 20 (20), pp. 6125-8. Date of Electronic Publication: 2010 Aug 10.

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

Autor: Chowdhury R; Department of Chemistry and Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK., McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ

Publikováno v: Structure (London, England : 1993) [Structure] 2009 Jul 15; Vol. 17 (7), pp. 981-9.

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

Autor: Hewitson KS; Chemistry Research Laboratory, The Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom., Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2008 Sep 19; Vol. 283 (38), pp. 25971-8. Date of Electronic Publication: 2008 Jul 08.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Autor: Gerken T; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK., Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ

Publikováno v: Science (New York, N.Y.) [Science] 2007 Nov 30; Vol. 318 (5855), pp. 1469-72. Date of Electronic Publication: 2007 Nov 08.