Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Krzysztof Z. Laczkowski"'
Autor:
Beata Donarska, Joanna Cytarska, Dominika Kołodziej-Sobczak, Renata Studzińska, Daria Kupczyk, Angelika Baranowska-Łączkowska, Karol Jaroch, Paulina Szeliska, Barbara Bojko, Daria Różycka, Agnieszka B. Olejniczak, Wojciech Płaziński, Krzysztof Z. Łączkowski
Publikováno v:
Molecules, Vol 29, Iss 19, p 4716 (2024)
The presented study depicts the synthesis of 11 carborane–thiazole conjugates with anticancer activity, as well as an evaluation of their biological activity as inhibitors of two enzymes: tyrosinase and 11β-hydroxysteroid dehydrogenase type 1 (11
Externí odkaz:
https://doaj.org/article/69915f806f04419f9a5b9cce74f6af71
Autor:
Przemysław Krawczyk, Beata Jędrzejewska, Joanna Cytarska, Klaudia Seklecka, Krzysztof Z. Łączkowski
Publikováno v:
Sensors, Vol 24, Iss 19, p 6368 (2024)
Carbazole is an aromatic heterocyclic organic compound consisting of two fused benzene rings and a pyrrole ring and is a very valuable building structure for the design of many compounds for use in various fields of chemistry and medicine. This study
Externí odkaz:
https://doaj.org/article/277684e45a8745ad867d1826ae3ecf9b
Autor:
Klaudia Dłubała, Sandra Wasiek, Patrycja Pilarska, Karolina Szewczyk-Golec, Celestyna Mila-Kierzenkowska, Krzysztof Z. Łączkowski, Marta Sobiesiak, Marcin Gackowski, Bartosz Tylkowski, Iga Hołyńska-Iwan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9670 (2024)
Retinoids are known to improve the condition of the skin. Transepithelial transport of sodium and chloride ions is important for proper skin function. So far, the effect of applying vitamin A preparations to the skin on ion transport has not been eva
Externí odkaz:
https://doaj.org/article/9e74900fb50f4a47905a04135ac44c65
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7033 (2024)
Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways and results in numerous human diseases. In particular, its involvement has been well documented in the pathogenesis of metabolic disorders (diabetes mellitus type I
Externí odkaz:
https://doaj.org/article/87ad50a5c8b947e59f7d2c14be78f715
Autor:
Sonia Kotowicz, Jan Grzegorz Małecki, Joanna Cytarska, Angelika Baranowska-Łączkowska, Mariola Siwy, Krzysztof Z. Łączkowski, Marcin Szalkowski, Sebastian Maćkowski, Ewa Schab-Balcerzak
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The seven N-phthalimide derivatives substituted with the amine group at the 3-C position in the phenylene ring were synthesized. The effect of N-substituent chemical structure was investigated. The thermal, electrochemical and optical studie
Externí odkaz:
https://doaj.org/article/3a8a924116d0444c867977148944b766
Autor:
Eugenia Gospodarek, Tomasz Plech, Krzysztof Z. Laczkowski, Konrad Misiura, Emilia Ciok-Pater, Anna Biernasiuk, Krzysztof Skowron, Agata Siwek, Anna Malm
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Synthesis, characterization and investigation of antibacterial and antifungal activities of twelve camphor based 2,4-disubstituted 1,3-thiazoles is presented. Their structures were determined using NMR, IR, FAB MS and HRMS analyses. Among the derivat
Autor:
Jéssica Alves Nunes, Rodrigo Santos Aquino de Araújo, Fabrícia Nunes da Silva, Joanna Cytarska, Krzysztof Z. Łączkowski, Sílvia Helena Cardoso, Francisco Jaime Bezerra Mendonça-Júnior, Edeildo Ferreira da Silva-Júnior
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5216 (2023)
Cancer represents the main cause of morbidity and mortality worldwide, constituting a serious health problem. In this context, melanoma represents the most aggressive and fatal type of skin cancer, with death rates increasing every year. Scientific e
Externí odkaz:
https://doaj.org/article/38e65253fef94e69a445d02fe2febac7
Autor:
Beata Donarska, Marta Świtalska, Joanna Wietrzyk, Wojciech Płaziński, Krzysztof Z. Łączkowski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 110 (2022)
Herein, nine phthalimide-based thiazoles (4a–4i) were synthesized and investigated as new human neutrophil elastase (HNE) inhibitors using spectrofluorimetric and computational methods. The most active compounds containing 4-trifluoromethyl (4c), 4
Externí odkaz:
https://doaj.org/article/4aae9e8845764e00a8382cf6d2a3caa0
Autor:
Joanna Cytarska, Artur Anisiewicz, Angelika Baranowska-Łączkowska, Adam Sikora, Joanna Wietrzyk, Konrad Misiura, Krzysztof Z. Łączkowski
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 3, Pp 303-311 (2019)
Synthesis, characterization and investigation of antiproliferative activity of nine triazene salts against human cancer cells lines (MV-4-11, MCF-7, JURKAT, HT-29, Hep-G2, HeLa, Du-145 and DAUDI), and normal human mammary epithelial cell line (MCF7-1
Externí odkaz:
https://doaj.org/article/0a0ab245701d4cbeb4798ccafac35683
Autor:
Beata Donarska, Marta Świtalska, Joanna Wietrzyk, Wojciech Płaziński, Magdalena Mizerska-Kowalska, Barbara Zdzisińska, Krzysztof Z. Łączkowski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7566 (2022)
A series of 3,3-diethylazetidine-2,4-dione based thiazoles 3a–3j were designed and synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The representative compounds 3c, 3e, and 3h exhibit high HNE inhibitory activity wi
Externí odkaz:
https://doaj.org/article/2ee7c676fe8144598a0b9bff4da9e363