Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Krzysztof W. Pankiewicz"'
Autor:
Jiexin Sheng, Zhongren Ma, Maikel P. Peppelenbosch, Herold J. Metselaar, Jaap Kwekkeboom, Kan Chen, Krzysztof W. Pankiewicz, Pratika Y. Hernanda, Krzysztof Felczak, Wanlu Cao, Buyun Ma, Dave Sprengers, Qiuwei Pan, Angela S. W. Tjon, Jiaye Liu, Patrick P.C. Boor
Publikováno v:
Transplantation, 103(5), 929-937. Lippincott Williams & Wilkins
Background. Tumor recurrence is a major complication following liver transplantation (LT) as treatment for hepatocellular carcinoma (HCC). Immunosuppression is an important risk factor for HCC recurrence, but conceivably may depend on the type of imm
Publikováno v:
Current Medicinal Chemistry. 22:3991-4028
About 500 NAD (P)-dependent enzymes in the cell use NAD (P) as a cofactor or a substrate. This family of broadly diversified enzymes is crucial for maintaining homeostasis of all living organisms. The NAD binding domain of these enzymes is conserved
Publikováno v:
Heterocyclic Communications. 21:249-257
Ribavirin, a broad-spectrum antiviral agent is used in the clinic alone or in combination with other antivirals and/or interferons. Numerous structural analogues of ribavirin have been developed, among them tiazofurin, which is inactive against virus
Autor:
Yijin Wang, Marion Koopmans, Yuebang Yin, Dave Sprengers, Luc J. W. van der Laan, Qiuwei Pan, Herold J. Metselaar, Krzysztof W. Pankiewicz, Maikel P. Peppelenbosch, Wen Dang, Kyeong-Ok Chang, Krzysztof Felczak, Junhong Su, Wenshi Wang
Publikováno v:
Antimicrobial Agents & Chemotherapy, 61(11):e01095-17. American Society for Microbiology
Norovirus is a major cause of acute gastroenteritis worldwide and has emerged as an important issue of chronic infection in transplantation patients. Since no approved antiviral is available, we evaluated the effects of different immunosuppressants a
Autor:
Krzysztof W, Pankiewicz
Publikováno v:
Current medicinal chemistry. 22(34)
Autor:
Ehsan Shokrollahi, Luc J. W. van der Laan, Wenshi Wang, Lei Xu, Qiuwei Pan, Krzysztof Felczak, Maikel P. Peppelenbosch, Krzysztof W. Pankiewicz, Nicolaas J. H. Raat, Yijin Wang, Dave Sprengers, Herold J. Metselaar, Xinying Zhou
Publikováno v:
Antimicrobial Agents & Chemotherapy, 60(5), 2834-2848. American Society for Microbiology
Viruses are solely dependent on host cells to propagate; therefore, understanding virus-host interaction is important for antiviral drug development. Since de novo nucleotide biosynthesis is essentially required for both host cell metabolism and vira
Autor:
Sevan Habeshian, J. Sebastian Temme, Isaac J. Krauss, Iain S. MacPherson, Krzysztof W. Pankiewicz, Krzysztof Felczak, Lizbeth Hedstrom
Publikováno v:
Angewandte Chemie. 123:11434-11438
A vast number of biological processes are mediated by multivalent ligand-receptor interactions, including cell adhesion, host invasion by pathogens, pathogen neutralization by host and numerous cell regulatory signaling pathways.[1] Multivalency is e
Publikováno v:
Current Medicinal Chemistry. 18:1891-1908
A large number of enzymes that use nicotinamide adenine dinucleotide NAD or its phosphorylated form NADP as a cofactor or substrate were found to play an important role in the growth and reproduction of living organisms. NAD(P)-dependent and NAD(P)-u
Autor:
Krzysztof W. Pankiewicz, Daniel J. Wilson, Liqiang Chen, Jessica Williams, Mohineesh Kumar, Robert Vince, Praveen Kusumanchi, Krzysztof Felczak, Hiremagalur N. Jayaram, Riccardo Petrelli
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1594-1605
Cofactor-type inhibitors of inosine monophosphate dehydrogenase (IMPDH) that target the nicotinamide adenine dinucleotide (NAD) binding domain of the enzyme are modular in nature. They interact with the three sub-sites of the cofactor binding domain;
Autor:
Krzysztof W. Pankiewicz
Publikováno v:
Current Medicinal Chemistry. 25:1817-1817