Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Krzysztof Szafrański"'
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 51 (2022)
During our research of biological activity of different N-aryl-4-substututed-pyridine-3-sulfonamides, we have found that compounds bearing a N-(quinolin-8-yl) substituent possess a significant anti-tumor activity. Mechanisms of anticancer activity of
Externí odkaz:
https://doaj.org/article/d3f19cfab1584b189913b4c6017f3ff2
Autor:
Simona Maria Monti, Angela Meccariello, Mariangela Ceruso, Krzysztof Szafrański, Jarosław Sławiński, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 255-259 (2018)
The two β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Brucella suis, BsuCA1 and BsuCA2, were investigated for their inhibition profile with a series of pyridine-3-sulphonamide derivatives incorporating 4-hetaryl moieties. Bsu
Externí odkaz:
https://doaj.org/article/33de48a7f818440f9965c64da43258e5
Autor:
Petar Žuvela, J. Jay Liu, Myunggi Yi, Paweł P. Pomastowski, Gulyaim Sagandykova, Mariusz Belka, Jonathan David, Tomasz Bączek, Krzysztof Szafrański, Beata Żołnowska, Jarosław Sławiński, Claudiu T. Supuran, Ming Wah Wong, Bogusław Buszewski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1430-1443 (2018)
In this work, a target-based drug screening method is proposed exploiting the synergy effect of ligand-based and structure-based computer-assisted drug design. The new method provides great flexibility in drug design and drug candidates with consider
Externí odkaz:
https://doaj.org/article/10af111bcd05473b8f60c43ce8cbd7a1
Autor:
Beata Żołnowska, Jarosław Sławiński, Mariusz Belka, Tomasz Bączek, Anna Kawiak, Jarosław Chojnacki, Aneta Pogorzelska, Krzysztof Szafrański
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 19101-19129 (2015)
A series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids. Some
Externí odkaz:
https://doaj.org/article/cfa356af1eb141edbe3ed4a952c6af57
Publikováno v:
Molecules, Vol 20, Iss 7, Pp 12029-12044 (2015)
A series of novel 4-substituted-N-(phenylcarbamoyl)-3-pyridinesulfonamides 11–27 have been synthesized by the reaction of 4-substituted pyridine-3-sulfonamides 2–10 with the appropriate aryl isocyanates in presence of potassium carbonate. The in
Externí odkaz:
https://doaj.org/article/9a6009ab626e41cca94c7f37fb9862fd
Publikováno v:
Molecules, Vol 22, Iss 11, p 1926 (2017)
Candidiasis represent a serious threat for patients with altered immune responses. Therefore, we have undertaken the synthesis of compounds comprising a pyridine-3-sulfonamide scaffold and known antifungally active 1,2,4-triazole substituents. Thus a
Externí odkaz:
https://doaj.org/article/072a79b51d174d2eb78f0c9ec3e76b2e
Autor:
Beata Żołnowska, Jarosław Sławiński, Aneta Pogorzelska, Krzysztof Szafrański, Anna Kawiak, Grzegorz Stasiłojć, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Jarosław Chojnacki
Publikováno v:
Molecules, Vol 21, Iss 6, p 808 (2016)
A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid
Externí odkaz:
https://doaj.org/article/989ecdc9655f4b0c8337523c6838227c
Autor:
Łukasz, Tomorowicz, Beata, Żołnowska, Krzysztof, Szafrański, Jarosław, Chojnacki, Ryszard, Konopiński, Ewa A, Grzybowska, Jarosław, Sławiński, Anna, Kawiak
Publikováno v:
International journal of molecular sciences. 23(13)
In the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::528aab1240d9a0c9efdbef12135eabba
https://pubmed.ncbi.nlm.nih.gov/35806186
https://pubmed.ncbi.nlm.nih.gov/35806186
Autor:
Anna Szczoczarz, Krzysztof Szafrański, Konrad Boblewski, Artur Lehmann, Jarosław Sławiński, Barbara Lewko, Apolonia apolonia.rybczynska@gumed.edu.pl
Publikováno v:
Acta Poloniae Pharmaceutica - Drug Research. 77:643-648
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ded5c09028d7e4f957ebc543b7fba39
https://doi.org/10.32383/appdr/126738
https://doi.org/10.32383/appdr/126738
Publikováno v:
Proceedings of 7th International Electronic Conference on Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd4629cb07be19e556647557404d355
https://doi.org/10.3390/ecmc2021-11446
https://doi.org/10.3390/ecmc2021-11446