Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Krzysztof Lemke"'
Autor:
Katarzyna Zima, Barbara Khaidakov, Marta Sochocka, Michał Ochnik, Krzysztof Lemke, Paulina Kowalczyk
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35630- (2024)
Previous studies have highlighted the beneficial properties of plants rich in polyphenols, such as Lonicera caerulea var. Kamtschatica Sevast. (LCK), Aronia melanocarpa (AM), and Echinacea purpurea (EP). These plants have demonstrated antioxidant, im
Externí odkaz:
https://doaj.org/article/55dd9f5c01a445e4ac1a893d95562dbf
Autor:
Przemysław Żmuda, Barbara Khaidakov, Maria Krasowska, Katarzyna Czapska, Michał Dobkowski, Julian Guzowski, Paulina Kowalczyk, Krzysztof Lemke, Marcin Folwarski, Aleksander Foryś, Ewa Domian, Marek Postuła
Publikováno v:
Applied Sciences, Vol 14, Iss 17, p 7718 (2024)
The purpose of this study was to evaluate the properties and pharmacokinetics of liposomal vitamin C in powder form obtained by a method devoid of organic solvents. The powder and liposome morphology were analyzed using scanning electron microscopy (
Externí odkaz:
https://doaj.org/article/45e417d2c611491fae5bc19d1334bf7d
Autor:
Katarzyna Zima, Barbara Khaidakov, Laura Banaszkiewicz, Krzysztof Lemke, Paulina Karolina Kowalczyk
Publikováno v:
Journal of Diabetes Research, Vol 2024 (2024)
Type 2 diabetes, characterized by insulin resistance and impaired glucose homeostasis, is commonly managed through lifestyle interventions and medications such as metformin. Although metformin is generally well-tolerated, it may cause gastrointestina
Externí odkaz:
https://doaj.org/article/47cd7e183cee4b09b971294fc896a272
Autor:
Monika Kuczyńska, Paulina Kasprzyk, Magdalena Leszczyńska-Wiloch, Joanna Bidzińska, Marcin Martyniak, Alicja Wilandt, Krzysztof Lemke
Publikováno v:
Postępy Higieny i Medycyny Doświadczalnej. 77:49-58
Introduction Due to the severe side effects of non-steroidal anti-inflammatory drugs, there is an urgent need to find new natural or synthetic chemicals that could act as selective inhibitors of cyclooxygenase-2 (COX-2). The most valuable source of n
Autor:
Danuta Pirska, Krzysztof Lemke, Andrzej Skladanowski, Marek Wojciechowski, Michal Sabisz, Marek T. Konieczny, Anita Buɬakowska, Wojciech Konieczny
Publikováno v:
Chemical Biology & Drug Design. 88:519-533
Synthesis, in vitro cytotoxic activity, and interaction with tubulin of oxidized, isomeric 1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-ones and 1-(6-alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1-ones are described. Most of the
Autor:
Wojciech Krzyczkowski, Bogdan Banecki, Alicja Ołdak, Leszek Kadziński, Krzysztof Lemke, Grzegorz Gawron
Publikováno v:
Journal of Ethnopharmacology. 244:112135
Ethnopharmacological relevance Nigella sativa L. seed extracts and oils have been embraced by traditional medicine of cultures inhabiting Middle East and North Africa for centuries. Among other uses, it has been applied against dermatitis and eczema
Autor:
Andrzej Skladanowski, Marek Wojciechowski, Krzysztof Lemke, Danuta Pirska, Marek T. Konieczny, Wojciech Strozek, Anita Buɬakowska, Michal Sabisz, Wojciech Konieczny, Anna Pieczykolan
Publikováno v:
European Journal of Medicinal Chemistry. 89:733-742
Synthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol-5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentra
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 42(1)
Chalcone constitutes one of the most used molecular frameworks in medicinal chemistry and its derivatives exhibit a broad spectrum of biological activities. Low absolute bioavailability, poor distribution, intensive metabolism and elimination of chal
Autor:
Rafal Derlacz, Urszula Florczyk, Anna Grochot-Przeczek, Maciej Ciesla, Jacek Stępniewski, Agnieszka Loboda, Magdalena Kozakowska, Alicja Jozkowicz, Marcin Majka, Jerzy Kotlinowski, Aleksandra Bartelik, Anna Stefanska, Krzysztof Szade, Anna Zebzda, Krzysztof Lemke, Klaudia Skrzypek, Agnieszka Szymula, Grzegorz Dyduch, Jozef Dulak, Halina Was, Agnieszka Jazwa, Witold Nowak, Milena Mazan, Oleksandr Yagensky
Publikováno v:
Antioxidants & Redox Signaling. 16:113-127
Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression is induced in response to oxidative stress. Its overexpression has been suggested as a strategy improving survival of t
Autor:
Marcin Wojciechowski, Annette K. Larsen, Andrzej Skladanowski, Krzysztof Lemke, Pierre Colson, Maciej Baginski, William Laine, Christian Bailly
Publikováno v:
Nucleic Acids Research
We recently reported that the antitumor triazoloacridone, compound C-1305, is a topoisomerase II poison with unusual properties. In this study we characterize the DNA interactions of C-1305 in vitro, in comparison with other topoisomerase II inhibito