Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Krzysztof Książek"'
Autor:
Julia Matuszewska, Adrianna Krawiec, Artur Radziemski, Paweł Uruski, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 3, Pp 151438- (2024)
The knowledge about cellular senescence expands dynamically, providing more and more conclusive evidence of its triggers, mechanisms, and consequences. Senescence-associated secretory phenotype (SASP), one of the most important functional traits of s
Externí odkaz:
https://doaj.org/article/6cb0b3414ffb408fa16812507ff59ea6
Autor:
Paweł Uruski, Julia Matuszewska, Aleksandra Leśniewska, Daniel Rychlewski, Arkadiusz Niklas, Justyna Mikuła-Pietrasik, Andrzej Tykarski, Krzysztof Książek
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-65 (2023)
Abstract Oncologic patients are subjected to four major treatment types: surgery, radiotherapy, chemotherapy, and immunotherapy. All nonsurgical forms of cancer management are known to potentially violate the structural and functional integrity of th
Externí odkaz:
https://doaj.org/article/60e436bd472142afb7adbda30872889d
Autor:
Szymon Rutecki, Paulina Szulc, Martyna Pakuła, Paweł Uruski, Artur Radziemski, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek
Publikováno v:
Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells. Experiments were performed on tumors and tumor-d
Externí odkaz:
https://doaj.org/article/f0ec4e0ce0de4b2898a4fa6ca73d1d87
Autor:
Agata Zientarska, Justyna Mikuła-Pietrasik, Mariusz Kaczmarek, Aleksandra Witkowska, Błażej Rozpłochowski, Arleta Kowala-Piaskowska, Krzysztof Książek, Jan Żeromski, Iwona Mozer-Lisewska
Publikováno v:
Central European Journal of Immunology, Vol 46, Iss 4, Pp 481-491 (2021)
Chronic hepatitis C (CHC) affects the activity of natural killer (NK) cells, but successful interferon- free treatment partially restores it. The goal of this study was to assess whether gender influences NK functionality. We examined 21 post-menopau
Externí odkaz:
https://doaj.org/article/6b7c7e6139c147018b8ac28db6503b9f
Autor:
Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek
Publikováno v:
Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-15 (2021)
Abstract Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management. Surprisingly, the effect of these drugs on ovar
Externí odkaz:
https://doaj.org/article/5137e29bb44c483cb438cacc9fb56a1e
Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts
Autor:
Paweł Uruski, Justyna Mikuła-Pietrasik, Martyna Pakuła, Sylwia Budkiewicz, Marcin Drzewiecki, Andrey N. Gaiday, Małgorzata Wierzowiecka, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Krzysztof Książek
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4222 (2021)
Although malignant ascites (MAs) are known to contribute to various aspects of ovarian cancer progression, knowledge regarding their role in the adhesion of cancer cells to normal peritoneal cells is incomplete. Here, we compared the effect of MAs an
Externí odkaz:
https://doaj.org/article/1b89f7f2dd4147c9a08a7f438c58a4c4
Autor:
Paweł Uruski, Justyna Mikuła-Pietrasik, Eryk Naumowicz, Kamila Kaźmierczak, Andrey N. Gaiday, Jan Królak, Błażej Nowakowski, Rafał Moszyński, Andrzej Tykarski, Krzysztof Książek
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 330 (2021)
The mechanisms and clinical significance of the cellular senescence of tumor cells are a matter of ongoing debate. Recently, the triggers and molecular events underlying spontaneous, replicative senescence of primary epithelial ovarian cancer cells w
Externí odkaz:
https://doaj.org/article/d20365f4865341f687620c0b90fb47e9
Autor:
Martyna Pakuła, Justyna Mikuła-Pietrasik, Anna Witucka, Katarzyna Kostka-Jeziorny, Paweł Uruski, Rafał Moszyński, Eryk Naumowicz, Stefan Sajdak, Andrzej Tykarski, Krzysztof Książek
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 137 (2019)
The role of the epithelial-mesenchymal transition (EMT) in ovarian cancer cell progression is unquestioned. In this report, we describe that malignant ascites, fluid that accumulates in the peritoneal cavity in a large group of patients with ovarian
Externí odkaz:
https://doaj.org/article/4cba6e26317f4b6ebdd405c5d7ba3946
Autor:
Krzysztof Książek, Marcin Wierzchowski, Katarzyna Piwocka, Patrycja Sosińska, Justyna Mikuła-Pietrasik
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 11, Pp 22483-22498 (2013)
3,3',4,4',5,5'-Hexahydroxy-trans-stilbene (M8) is a synthetic resveratrol derivative, advertised as a candidate drug highly effective against numerous malignancies. Because multiple tumors prone to M8 frequently metastasize into the peritoneal cavity
Externí odkaz:
https://doaj.org/article/91079574fdf14cf0a8cb44935c419921
Autor:
Krzysztof Książek
Publikováno v:
Seminars in Cancer Biology. 81:14-23
Although ovarian cancer is the leading cause of death from gynecological malignancies, there are still some issues that hamper accurate interpretation of the complexity of cellular and molecular events underlying the pathophysiology of this disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4eb07837302286143526f2ab76bb9f
https://doi.org/10.1016/j.semcancer.2020.11.021
https://doi.org/10.1016/j.semcancer.2020.11.021