Identification of functional features underlying heat stress response in Sprague–Dawley rats using mixed linear models

Autor: Krzysztof Kotlarz, Magda Mielczarek, Yachun Wang, Jinhuan Dou, Tomasz Suchocki, Joanna Szyda

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)

Abstract Since global temperature is expected to rise by 2 °C in 2050 heat stress may become the most severe environmental factor. In the study, we illustrate the application of mixed linear models for the analysis of whole transcriptome expression

Externí odkaz: https://doaj.org/article/e998b7a17d974e2f8da6454bc8f17d57

The application of mixed linear models for the estimation of functional effects on bovine stature based on SNP summary

Autor: Krzysztof Kotlarz, Barbara Kosinska-Selbi, Zexi Cai, Goutam Sahana, Joanna Szyda

Publikováno v: Kotlarz, K, Kosinska-Selbi, B, Cai, Z, Sahana, G & Szyda, J 2022, The application of mixed linear models for the estimation of functional effects on bovine stature based on SNP summary . in WCGALP 2022 Programme book . Wageningen Academic Publishers, World Congress on Genetics Applied to Livestock Production, Rotterdam, Netherlands, 03/07/2022 . < https://www.wageningenacademic.com/pb-assets/wagen/WCGALP2022/11_004.pdf >
Aarhus University

Genome-Wide Association Studies (GWAS) help identify polymorphic sites or genes linked to phenotypic variance, but a few genes / SNPs are unlikely to explain the phenotypic variability of complex traits. In the study, the focus was moved from single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a1331e7746f0158da548973f23266b65
https://pure.au.dk/portal/da/publications/the-application-of-mixed-linear-models-for-the-estimation-of-functional-effects-on-bovine-stature-based-on-snp-summary(369c6eb2-745d-4631-9dda-dcb710d64991).html

The application of deep learning for the classification of correct and incorrect SNP genotypes from whole-genome DNA sequencing pipelines

Autor: Magda Mielczarek, Krzysztof Kotlarz, Joanna Szyda, Bernt Guldbrandtsen, Bartosz Czech, Tomasz Suchocki

Publikováno v: J Appl Genet
Journal of Applied Genetics

A downside of next-generation sequencing technology is the high technical error rate. We built a tool, which uses array-based genotype information to classify next-generation sequencing–based SNPs into the correct and the incorrect calls. The deep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28f49e7e5b2d14823f1d9458b386fbf
https://doi.org/10.1007/s13353-020-00586-0

Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?

Autor: Joanna Szyda, Paula Dobosz, Joanna Stojak, Mateusz Sypniewski, Tomasz Suchocki, Krzysztof Kotlarz, Magdalena Mroczek, Maria Stępień, Dawid Słomian, Sławomir Butkiewicz, Paweł Sztromwasser, Jakub Liu, Zbigniew J. Król

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6272

COVID-19 infections pose a serious global health concern so it is crucial to identify the biomarkers for the susceptibility to and resistance against this disease that could help in a rapid risk assessment and reliable decisions being made on patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b413f9ca5f7f77ae9ddd4b46885260
https://doi.org/10.3390/ijms23116272