Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Krzysztof J. Wypijewski"'
Autor:
Jacqueline Howie, Lindsay B. Tulloch, Elaine Brown, Louise Reilly, Fiona B. Ashford, Jennifer Kennedy, Krzysztof J. Wypijewski, Karen L. Aughton, Jason K.C. Mak, Michael J. Shattock, Niall J. Fraser, William Fuller
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113679- (2024)
Summary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoy
Externí odkaz:
https://doaj.org/article/dcac5956dc204ac4934750eee8fdf86f
Autor:
Chien-Wen S. Kuo, Sara Dobi, Caglar Gök, Ana Da Silva Costa, Alice Main, Olivia Robertson-Gray, Daniel Baptista-Hon, Krzysztof J. Wypijewski, Hannah Costello, Tim G. Hales, Niall MacQuaide, Godfrey L. Smith, William Fuller
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Mammalian voltage-activated L-type Ca 2+ channels, such as Ca(v)1.2, control transmembrane Ca 2+ fluxes in numerous excitable tissues. Here, we report that the pore-forming α1C subunit of Ca(v)1.2 is reversibly palmitoylated in rat, rabbit, and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c2fae4312e674df261a80212025248
https://doi.org/10.1073/pnas.2207887120
https://doi.org/10.1073/pnas.2207887120
Autor:
Juan F. Cervilla-Martínez, Juan J. Rodríguez-Gotor, Krzysztof J. Wypijewski, Ángela Fontán-Lozano, Tao Wang, Enrique Santamaría, William Fuller, Rebeca Mejías
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14018
This article belongs to the Special Issue Towards Precision Prognostication and Personalized Therapeutics through Proteomics.
The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's d
The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d578484b305a1a4a533982b39c0798ba
Publikováno v:
Biochemical Society transactions. 48(1)
The post-translational modification protein S-acylation (commonly known as palmitoylation) plays a critical role in regulating a wide range of biological processes including cell growth, cardiac contractility, synaptic plasticity, endocytosis, vesicl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bdcd5b5c837bc97d324fc3326d2a34
https://pubmed.ncbi.nlm.nih.gov/31872231
https://pubmed.ncbi.nlm.nih.gov/31872231
Autor:
Krzysztof J. Wypijewski, William Fuller, Jacqueline Howie, Lindsay B. Tulloch, Niall J. Fraser, Fiona Plain
Publikováno v:
Critical reviews in biochemistry and molecular biology. 53(2)
The ubiquitous sodium/potassium ATPase (Na pump) is the most abundant primary active transporter at the cell surface of multiple cell types, including ventricular myocytes in the heart. The activity of the Na pump establishes transmembrane ion gradie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452905611692aef11f4304b5f449e538
https://pubmed.ncbi.nlm.nih.gov/29424237
https://pubmed.ncbi.nlm.nih.gov/29424237
Autor:
Heather McClafferty, Michael J. Shipston, Jacqueline Howie, William Fuller, Lijun Tian, Krzysztof J. Wypijewski, Michael L.J. Ashford, Sarah Calaghan, Julia M. Vlachaki Walker, Andrii Boguslavskyi, Niall J. Fraser, Louise Reilly, Michael J. Shattock
Publikováno v:
Proceedings of the National Academy of Sciences. 111:17534-17539
The cardiac phosphoprotein phospholemman (PLM) regulates the cardiac sodium pump, activating the pump when phosphorylated and inhibiting it when palmitoylated. Protein palmitoylation, the reversible attachment of a 16 carbon fatty acid to a cysteine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f84623d5ceabbc477ceea2741fb25ff
https://doi.org/10.1073/pnas.1413627111
https://doi.org/10.1073/pnas.1413627111
Autor:
Karen L. Aughton, Krzysztof J. Wypijewski, Jacqueline Howie, William Fuller, Lindsay B. Tulloch, Linda M. McLatchie, Louise Reilly, Michael J. Shattock, Sarah Calaghan
Publikováno v:
Journal of Biological Chemistry. 288:13808-13820
Phospholemman (PLM), the principal quantitative sarcolemmal substrate for protein kinases A and C in the heart, regulates the cardiac sodium pump. Much like phospholamban, which regulates the related ATPase SERCA, PLM is reported to oligomerize. We i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222cb51ae7808b29eefaf4938dc2a6c3
https://doi.org/10.1074/jbc.m113.460956
https://doi.org/10.1074/jbc.m113.460956
Autor:
Krzysztof J, Wypijewski, Michele, Tinti, Wenzhang, Chen, Douglas, Lamont, Michael L J, Ashford, Sarah C, Calaghan, William, Fuller
Publikováno v:
Molecular & Cellular Proteomics : MCP
The lipid raft concept proposes that membrane environments enriched in cholesterol and sphingolipids cluster certain proteins and form platforms to integrate cell signaling. In cardiac muscle, caveolae concentrate signaling molecules and ion transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61c9ab4c65e79bbabe04d0ad808fef8d
https://pubmed.ncbi.nlm.nih.gov/25561500
https://pubmed.ncbi.nlm.nih.gov/25561500
Autor:
Krzysztof J, Wypijewski, Jacqueline, Howie, Louise, Reilly, Lindsay B, Tulloch, Karen L, Aughton, Linda M, McLatchie, Michael J, Shattock, Sarah C, Calaghan, William, Fuller
Publikováno v:
The Journal of biological chemistry. 288(19)
Phospholemman regulates the plasmalemmal sodium pump in excitable tissues.In cardiac muscle, a subpopulation of phospholemman with a unique phosphorylation signature associates with other phospholemman molecules but not with the pump.Phospholemman ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d54464c20a9c53b0dd9cfa6a22d5aeab
https://pubmed.ncbi.nlm.nih.gov/23532852
https://pubmed.ncbi.nlm.nih.gov/23532852
Autor:
William Fuller, Lindsay B. Tulloch, Sarah Calaghan, Jacqueline Howie, Krzysztof J. Wypijewski, Michael J. Shattock
Publikováno v:
Cellular and Molecular Life Sciences
In cardiac muscle, the sarcolemmal sodium/potassium ATPase is the principal quantitative means of active transport at the myocyte cell surface, and its activity is essential for maintaining the trans-sarcolemmal sodium gradient that drives ion exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582a2ade32712a04ce9d2c15f5c0a87e
https://pubmed.ncbi.nlm.nih.gov/22955490
https://pubmed.ncbi.nlm.nih.gov/22955490