Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Krzysztof Darlak"'
Autor:
Dusan Vasicek, Krzysztof Darlak, Alexander V. Sirotkin, Jan Kotwica, Francisco Valenzuela, Silvia Pavlová, Andrej Benco, Jirina Zemanová
Publikováno v:
REPRODUCTION. 138:553-560
The aim of ourin vitroexperiments was to study the role of the transcription factor STAT1 and the hormone ghrelin in controlling porcine ovarian function. The effects of treatment with ghrelin (0, 1, 10, 100 ng/ml), transfection-induced overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cbd4eda742dccb23805e5f840d5f3
https://doi.org/10.1530/rep-08-0313
https://doi.org/10.1530/rep-08-0313
Publikováno v:
The Journal of Peptide Research. 63:52-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ab33d2bc1b12629bed75fc20b8a225
https://doi.org/10.1111/j.1399-3011.2004.00136.x
https://doi.org/10.1111/j.1399-3011.2004.00136.x
Autor:
Maria Chrenková, Manuel Tena-Sempere, Francisco Valenzuela, Alexander V. Sirotkin, Soňa Nitrayová, Krzysztof Darlak, Peter Patráš, Leonor Pinilla
Publikováno v:
Peptides. 29:1362-1368
The existence of a close relationship between energy status and reproductive function is well-documented, especially in females, but its underlying mechanisms remain to be fully unfolded. This study aimed to examine the effects of restriction of dail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8295ccbe3708981cbcff6da354af2df
https://doi.org/10.1016/j.peptides.2008.03.011
https://doi.org/10.1016/j.peptides.2008.03.011
Publikováno v:
Macrocycles in Drug Discovery ISBN: 9781849737012
Macrocyclic α-helical peptides have emerged as a promising new drug class and within the scope of hydrocarbon-stapled peptides such molecules have advanced into the clinic. The overarching concept of designing proteomimetics of an α-helical ‘liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3ce01ddf8b9104f32894e70f798188
https://doi.org/10.1039/9781782623113-00339
https://doi.org/10.1039/9781782623113-00339
Autor:
Krzysztof Darlak, Hongliang Cai, Eric Feyfant, Tomi K. Sawyer, Packman Kathryn E, Lyubomir T. Vassilev, Christian Tovar, Carl Elkin, Huw M. Nash, James Horstick, D. Allen Annis, Vincent Guerlavais, Anthony M. Manning, Nader Fotouhi, Aditi Mukherjee, Xiangguo E. Shi, Karen A. Olson, Kwong-Him To, Kamala Kesavan, Yong S. Chang, Pamela Berry, Theresa Baker, Zoran Filipovic, Bradford Graves, Farooq Qureshi, Pranoti Gangurde
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Stapled α-helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and MDMX, ATSP-7041, which effectively activates the p53 pathway in tumors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf7583698e4f39a7bb9cea1d284dbf
https://doi.org/10.1073/pnas.1303002110
https://doi.org/10.1073/pnas.1303002110
Autor:
J. M. Fisher, B. B. Wang, Bruce Walcheck, R. S. Fisk, Donald G. Payan, Raj Betageri, Takashi Kei Kishimoto, Arno F. Spatola, Julius Kahn, Krzysztof Darlak, Carol Feehan
Publikováno v:
Nature. 380:720-723
The L-selectin adhesion molecule is involved in guiding leukocytes to sites of inflammation. L-selectin is cleaved by an unusual proteolytic activity at a membrane-proximal site resulting in rapid shedding from the cell surface. Although it has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788b5fc63b791df15f64c81f051fb942
https://doi.org/10.1038/380720a0
https://doi.org/10.1038/380720a0
Autor:
Carol Feehan, Bruce Walcheck, Arno F. Spatola, Julius Kahn, Takashi Kei Kishimoto, Krzysztof Darlak
Publikováno v:
Journal of Biological Chemistry. 271:7019-7024
Expression of the L-selectin adhesion molecule can be rapidly down-modulated by regulated proteolysis at a membrane-proximal site. The L-selectin secretase has remained undefined, and the secretase activity is resistant to a broad panel of common pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f50847ca925c442b828d89b7afeb23c
https://doi.org/10.1074/jbc.271.12.7019
https://doi.org/10.1074/jbc.271.12.7019
Publikováno v:
Tetrahedron Letters. 37:591-594
Using an amino acid linked by its side chain to a solid support, head-to-tail cyclic peptide libraries of varying ring size have been prepared via resin-bound cyclization. These mixtures complement the use of linear peptide libraries for drug lead di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::889217f02e604103d42a61c436cc9333
https://doi.org/10.1016/0040-4039(95)02269-4
https://doi.org/10.1016/0040-4039(95)02269-4
Autor:
Nga N. Chung, Annika B. Malmberg, Arno F. Spatola, Thomas F. Burks, Qin Zhu, Murray Goodman, Seonggu Ro, Tony L. Yaksh, Krzysztof Darlak, Peter W. Schiller, Chang‐Woo Lee
Publikováno v:
Journal of Peptide Science. 1:157-174
Our continuing efforts to study structure-activity relationships of peptide opioids have resulted in the synthesis of a series of cyclic opioids related to dermorphins and deltorphins. The biological activities of the compounds have been determined a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38d3f70608c966f2feb24cc8fa71ae7
https://doi.org/10.1002/psc.310010303
https://doi.org/10.1002/psc.310010303
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e001abbb7c30a17e54f77ee3a5d9cff
https://doi.org/10.1002/chin.200023254
https://doi.org/10.1002/chin.200023254