Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Krzysztof Bielawski"'
Autor:
Anna Szymanowska, Dominika Radomska, Robert Czarnomysy, Mariusz Mojzych, Katarzyna Kotwica-Mojzych, Krzysztof Bielawski, Anna Bielawska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo
Externí odkaz:
https://doaj.org/article/2e41339fa6ed48cf9810dde5aa33ba0e
Autor:
Piotr Roszczenko, Olga Klaudia Szewczyk-Roszczenko, Agnieszka Gornowicz, Robert Czarnomysy, Andrii Lozynskyi, Krzysztof Bielawski, Roman Lesyk, Anna Bielawska
Publikováno v:
Molecules, Vol 29, Iss 21, p 5117 (2024)
Gastric cancer remains a significant therapeutic challenge, highlighting the need for new strategies to improve treatment efficacy. This study investigates the potential of combined therapy with the novel Thiopyrano[2,3-d]Thiazole derivative LES-6400
Externí odkaz:
https://doaj.org/article/63e32af91ecf4a15b62cbf2959f0edb0
Publikováno v:
Problemy Mechatroniki, Vol 14, Iss 2, Pp 127-136 (2023)
For two decades, AREX Sp. z o.o. (Gdynia, Poland), belonging to WB Group (Warsaw, Poland), has been dealing with special-purpose production, in particular mechatronics, and its solutions are used in electromechanical accessories for 155 mm KRAB gun-h
Externí odkaz:
https://doaj.org/article/f08f5297b5754d53af03c0cc30d0f1b1
Autor:
Paweł Misiak, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Przemysław Wielgat, Izabela Kurowska, Robert Czarnomysy, Iwona Misztalewska-Turkowicz, Halina Car, Krzysztof Bielawski, Agnieszka Z. Wilczewska
Publikováno v:
Cancer Nanotechnology, Vol 14, Iss 1, Pp 1-25 (2023)
Highlights 1. DDS based on cholesterol, ketoester, and NIPAAm, designed for the delivery of DOX. 2. The ketoester and arrangement of blocks are crucial for anticancer activity. 3. PNPs not only act as transporters but also sensitize the cell to DOX.
Externí odkaz:
https://doaj.org/article/019217dfb4c6466c857824351eaface4
Autor:
Emilia Szymańska, Joanna Potaś, Marcin Baranowski, Robert Czarnomysy, Magdalena Ewa Sulewska, Anna Basa, Małgorzata Pietruska, Krzysztof Bielawski, Katarzyna Winnicka
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2512 (2023)
Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal epithelium.
Externí odkaz:
https://doaj.org/article/05c5712050794653b703ea02645b84ae
Autor:
Olga Klaudia Szewczyk-Roszczenko, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, Krzysztof Bielawski
Publikováno v:
Cells, Vol 12, Iss 18, p 2312 (2023)
Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, dis
Externí odkaz:
https://doaj.org/article/240d6a12375b49b7b04c384bef8ac300
Autor:
Justyna Magdalena Hermanowicz, Anna Szymanowska, Beata Sieklucka, Robert Czarnomysy, Krystyna Pawlak, Anna Bielawska, Krzysztof Bielawski, Joanna Kalafut, Alicja Przybyszewska, Arkadiusz Surazynski, Adolfo Rivero-Muller, Mariusz Mojzych, Dariusz Pawlak
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 535-548 (2021)
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebra
Externí odkaz:
https://doaj.org/article/16356bbb3b0d4b34b72198eeb4905e86
Autor:
Aleksandra Maria Juszczak, Katarzyna Jakimiuk, Robert Czarnomysy, Jakub Władysław Strawa, Marijana Zovko Končić, Krzysztof Bielawski, Michał Tomczyk
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The effects of different extracts obtained from Jasione montana L. (JM1–JM6) and their main metabolites on biological processes during wound healing were evaluated. The effect on wound closure in the scratch test was established, and collagen type
Externí odkaz:
https://doaj.org/article/197ee0584360468ab693e0b5eb72d054
Autor:
Dariusz Rozkiewicz, Justyna Magdalena Hermanowicz, Anna Tankiewicz-Kwedlo, Beata Sieklucka, Krystyna Pawlak, Robert Czarnomysy, Krzysztof Bielawski, Arkadiusz Surazynski, Joanna Kalafut, Alicja Przybyszewska, Mariusz Koda, Katarzyna Jakubowska, Adolfo Rivero-Muller, Dariusz Pawlak
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1697-1711 (2020)
Recombinant human erythropoietin (Epo) is an effective and convenient treatment for cancer-related anaemia. In our study for the first time, we evaluated the effect of simultaneous use of Epo and Bruton’s tyrosine kinase (BTK) inhibitor LFM-A13 on
Externí odkaz:
https://doaj.org/article/418377d1f791473ea76404dcb6f5a02c
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1781-1799 (2020)
The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cell
Externí odkaz:
https://doaj.org/article/96206ff0080a4bdea0c7c1d7b70bfb1d