Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Krzysztof, Wrzesinski"'
Publikováno v:
Cells, Vol 12, Iss 15, p 1980 (2023)
Small-cell lung cancer is a fast-growing carcinoma with a poor prognosis and a high level of relapse due to multi-drug resistance (MDR). Genetic mutations that lead to the overexpression of efflux transporter proteins can contribute to MDR. In vitro
Externí odkaz:
https://doaj.org/article/dc8d6662ca87427a85064bf78637c847
Autor:
Chrisna Gouws, Tanya Smit, Clarissa Willers, Hanna Svitina, Carlemi Calitz, Krzysztof Wrzesinski
Publikováno v:
Molecules, Vol 26, Iss 3, p 605 (2021)
Colorectal cancer remains to be one of the leading causes of death worldwide, with millions of patients diagnosed each year. Although chemotherapeutic drugs are routinely used to treat cancer, these treatments have severe side effects. As a result, t
Externí odkaz:
https://doaj.org/article/f49f672e30a344aeaebdac0d4594289c
Publikováno v:
Toxicology Research
Medicines are usually prescribed for repeated use over shorter or longer times. Unfortunately, repeated-dose animal toxicity studies do not correlate well with observations in man. As emphasized by the ‘3Rs’ and the desire to phase-out animal res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89193b2468c85105ef8fc7bd59383166
http://europepmc.org/articles/PMC7467243
http://europepmc.org/articles/PMC7467243
Autor:
Krzysztof Wrzesinski, Tanya Smit, Stephen J. Fey, Carlemi Calitz, Chrisna Gouws, Josias H. Hamman, Hanna Svitina, Clarissa Willers
Publikováno v:
ACS Med Chem Lett
[Image: see text] Colorectal cancer is one of the leading causes of cancer-related deaths. A main problem for its treatment is resistance to chemotherapy, requiring the development of new drugs. The success rate of new candidate cancer drugs in clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90ebd6b9532b1a6baae80d5671e2043
https://doi.org/10.1021/acsmedchemlett.0c00076
https://doi.org/10.1021/acsmedchemlett.0c00076
Autor:
Krzysztof Wrzesinski, Stephen J. Fey
Publikováno v:
Bioengineering, Vol 5, Iss 1, p 22 (2018)
The recovery of physiological functionality, which is commonly seen in tissue mimetic three-dimensional (3D) cellular aggregates (organoids, spheroids, acini, etc.), has been observed in cells of many origins (primary tissues, embryonic stem cells (E
Externí odkaz:
https://doaj.org/article/826236179d6042e0a4df82cfdcab92ec
Autor:
Julie S. Vistisen, Peter Willems Alnøe, Torsten D. Bryld, Krzysztof Wrzesinski, Stephen J. Fey, Hans H. Jochumsen, Søren Alnøe, Karoline Mikkelsen
Culturing cells in 3D is often considered to be significantly more difficult than culturing them in 2D. In practice, this is not the case: the situation is that equipment needed for 3D cell culture has not been optimised as much as equipment for 2D.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfd97248f224e3ad8b9f4f4c54298c5
https://doi.org/10.5772/intechopen.96091
https://doi.org/10.5772/intechopen.96091
Autor:
Krzysztof Wrzesinski, Adelina Rogowska-Wrzesinska, Rattiyaporn Kanlaya, Kamil Borkowski, Veit Schwämmle, Jie Dai, Kira Eyd Joensen, Katarzyna Wojdyla, Vasco Botelho Carvalho, Stephen J Fey
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106973 (2014)
IntroductionCellular metabolism can be considered to have two extremes: one is characterized by exponential growth (in 2D cultures) and the other by a dynamic equilibrium (in 3D cultures). We have analyzed the proteome and cellular architecture at th
Externí odkaz:
https://doaj.org/article/3c70e09da22e47088527cdadde0fcb57
Autor:
Krzysztof, Wrzesinski, Helle Sedighi, Frandsen, Carlemi, Calitz, Chrisna, Gouws, Barbara, Korzeniowska, Stephen J, Fey
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2273
Growing cells as 3D structures need not be difficult. Often, it is not necessary to change cell type, additives or growth media used. All that needs to be changed is the geometry: cells (whether primary, induced pluripotent, transformed or immortal)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d6c59b38948e48913f0cf3e5901f4fb
https://pubmed.ncbi.nlm.nih.gov/33604843
https://pubmed.ncbi.nlm.nih.gov/33604843
Autor:
Metka Filipič, Adelina Rogowska-Wrzesinska, Bojana Žegura, Helle Sedighi Frandsen, Krzysztof Wrzesinski, Martina Štampar
Publikováno v:
Štampar, M, Sedighi Frandsen, H, Rogowska-Wrzesinska, A, Wrzesinski, K, Filipič, M & Žegura, B 2021, ' Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals ', Science of the Total Environment, vol. 755, no. Part 2, 143255 . https://doi.org/10.1016/j.scitotenv.2020.143255
The major weakness of the current in vitro genotoxicity test systems is the inability of the indicator cells to express metabolic enzymes needed for the activation and detoxification of genotoxic compounds, which consequently can lead to misleading r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fea8fd17f3b15d3264ff1e6752eca75
https://findresearcher.sdu.dk:8443/ws/files/174901506/1_s2.0_S0048969720367863_main.pdf
https://findresearcher.sdu.dk:8443/ws/files/174901506/1_s2.0_S0048969720367863_main.pdf
Autor:
Clarissa Willers, Krzysztof Wrzesinski, Tanya Smit, Hanna Svitina, Carlemi Calitz, Chrisna Gouws
Publikováno v:
Molecules, Vol 26, Iss 605, p 605 (2021)
Molecules
Volume 26
Issue 3
Molecules
Volume 26
Issue 3
Colorectal cancer remains to be one of the leading causes of death worldwide, with millions of patients diagnosed each year. Although chemotherapeutic drugs are routinely used to treat cancer, these treatments have severe side effects. As a result, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68abf7802cbcf6e2244f618c3e487925
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448202
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448202