KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.

Autor: Mühlenberg T; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany., Falkenhorst J; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany., Schulz T; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany., Fletcher BS; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany., Teuber A; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany., Krzeciesa D; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany., Klooster I; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Lundberg M; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Wilson L; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Lategahn J; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany., von Mehren M; Department of Hematology and Oncology, Fox Chase Cancer Center, Temple Health System, University, Philadelphia, PA., Grunewald S; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany., Tüns AI; Laboratory of Molecular Oncology, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany., Wardelmann E; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany., Sicklick JK; Department of Surgery, Division of Surgical Oncology, University of California San Diego, San Diego, CA.; Department of Pharmacology, Moores Cancer Center, University of California San Diego, San Diego, CA., Brahmi M; Centre Leon Berard, Medical Oncology, Lyon, France., Serrano C; Sarcoma Translational Research Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.; Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Schildhaus HU; University Hospital Essen, Institute of Pathology, Essen, Germany.; Current affiliation: Discovery Life Sciences Biomarker Services & Institute of Pathology Nodhessen, Kassel, Germany., Sievers S; Compound Management and Screening Center, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Treckmann J; University of Duisburg-Essen, Medical School, Department of Visceral and Transplantation Surgery, Essen, Germany., Heinrich MC; Portland VA Health Care System and OHSU Knight Cancer Institute, Portland, OR., Raut CP; Department of Surgery, Brigham and Women's Hospital, Boston, MA.; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA.; Harvard Medical School, Boston, MA., Ou WB; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China., Marino-Enriquez A; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., George S; Dana-Farber Cancer Institute, Medical Oncology, Boston, MA., Rauh D; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany., Fletcher JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Bauer S; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Apr 20; Vol. 42 (12), pp. 1439-1449. Date of Electronic Publication: 2024 Feb 26.

Evaluation of mismatch repair deficiency as predictive biomarker in novel sarcoma cell line models

Autor: Dieckmann, N., Mühlenberg, Thomas, Krzeciesa, D., Borchert, S., Schildhaus, Hans-Ulrich, Bauer, Sebastian

Poster-Abstract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=unidue___bib::a2975aa30ea740f0936d20c19e0578ce

Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability.

Autor: Haller V; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Reiff C; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Hamacher R; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Kostbade K; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Kaths M; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.; Department of Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany., Treckmann J; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.; Department of Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany., Bertram S; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.; Department of Pathology, University Hospital Essen, Essen, Germany., Zaun Y; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany., Bauer S; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany. sebastian.bauer@uk-essen.de.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany. sebastian.bauer@uk-essen.de., Falkenhorst J; Department of Medical Oncology and Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Nov 09; Vol. 150 (11), pp. 489. Date of Electronic Publication: 2024 Nov 09.