Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Krystyna Patora-Komisarska"'
Autor:
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 749-763.e12 (2019)
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylas
Externí odkaz:
https://doaj.org/article/9e48897b13e34703b8199ceb48040546
Autor:
Liz S. Wilson, Joseph Cruz, David J. Glass, John Concannon, Berndt Oberhauser, Brian A. Clarke, Yunyu Zhang, Anne-Ulrike Trendelenburg, Yuan Wang, Krystyna Patora-Komisarska, Nicole Hupper
Facioscapulohumeral muscular dystrophy (FSHD) is among the most prevalent of the adult-onset muscular dystrophies. FSHD causes a loss of muscle mass and function, resulting in severe debilitation and reduction in quality of life. Currently, only the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5284eae687a42f1af0f10d5516593b33
https://europepmc.org/articles/PMC6066320/
https://europepmc.org/articles/PMC6066320/
Autor:
John A. Robinson, Gabriele Varani, Zahra Shajani, Krystyna Patora-Komisarska, Michael F. Bardaro
Publikováno v:
Nucleic Acids Research
The HIV-1 TAR RNA represents a well-known paradigm to study the role of dynamics and conformational change in RNA function. This regulatory RNA changes conformation in response to binding of Tat protein and of a variety of peptidic and small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d374e3ec5ee2d56167de4f9b94611b7
http://doc.rero.ch/record/302046/files/gkn1074.pdf
http://doc.rero.ch/record/302046/files/gkn1074.pdf
Publikováno v:
Bioorganic & Medicinal Chemistry
Bioorg. Med. Chem.
Bioorganic and Medicinal Chemistry
Bioorg. Med. Chem.
Bioorganic and Medicinal Chemistry
We report structural studies in aqueous solution on backbone cyclic peptides that possess potent antimicrobial activity specifically against Pseudomonas sp. The peptides target the β-barrel outer membrane protein LptD, which plays an essential role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6101d15d66e6aa5e9416528f1d8f530
https://doi.org/10.1016/j.bmc.2013.07.013
https://doi.org/10.1016/j.bmc.2013.07.013
Publikováno v:
Helvetica Chimica Acta. 94:719-745
The amine-catalyzed enantioselective Michael addition of aldehydes to nitro alkenes (Scheme 1) is known to be acid-catalyzed (Fig. 1). A mechanistic investigation of this reaction, catalyzed by diphenylprolinol trimethylsilyl ether is described. Of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7770140470c1e9ca7ec37f26ab366a21
https://doi.org/10.1002/hlca.201100122
https://doi.org/10.1002/hlca.201100122
Publikováno v:
Helvetica Chimica Acta. 94:1-17
Fmoc-β2hSer(tBu)-OH was converted to Fmoc-β2hSec(PMB)-OH in five steps. To avoid elimination of HSeR, the selenyl group was introduced in the second last step (Fmoc-β2hSer(Ts)-OAllFmoc-β2hSec(PMB)-OAll). In a similar way, the N-Boc-protected comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1741c5bc1b5c6ef6ac831b0bf3403d2a
https://doi.org/10.1002/hlca.201000409
https://doi.org/10.1002/hlca.201000409
Autor:
Faustin Kamena, Bopanna Monnanda, Stefania Capone, Dieter Seebach, Danielle Makou, Krystyna Patora-Komisarska
Publikováno v:
Chemistry & Biodiversity. 8:1-12
Fluorescein-labeled α- and β-octaarginine amides were synthesized. The route, by which these oligoarginine (OA) derivatives enter cells (hepatocytes, fibroblasts, macrophages), was investigated by confocal fluorescence microscopy. Comparisons (by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e1cac7a74e7b6c7877b22b2b3cf15
https://doi.org/10.1002/cbdv.201000318
https://doi.org/10.1002/cbdv.201000318
Autor:
Ekatarina Otchertianova, Dieter Seebach, Hanspeter Sprecher, Roger Marti, Manuel Möri, Christoph Gaul, Albert K. Beck, Krystyna Patora-Komisarska, Stefan Pletscher
Publikováno v:
Helvetica Chimica Acta. 93:90-110
A number of N-acryloyl-, N-crotonoyl-, N-(3,3,3-trifluorocrotonoyl)-, N-cinnamoyl-, and N-(3-nitroacryloyl)-4-isopropyl- or -4-phenyl-oxazolidin-2-ones with geminal diphenyl substitution, i.e., 7–15, have been prepared and used for conjugate additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8256a65e3084780c8730fa923f9023d
https://doi.org/10.1002/hlca.200900385
https://doi.org/10.1002/hlca.200900385
Autor:
Beatrice Waser, Renzo Cescato, Dominika Jadwiga Podwysocka, Peter Gmeiner, Catherine Rougeot, Krystyna Patora-Komisarska, Dieter Seebach, Marc-Olivier Ebert, Jean Claude Reubi, James Gardiner, Harald Hübner, Aneta Lukaszuk
Publikováno v:
Chemistrybiodiversity. 8(5)
The terminal homologation by CH(2) insertion into the peptides mentioned in the title is described. This involves replacement of the N-terminal amino acid residue by a β(2) - and of the C-terminal amino acid residue by a β(3) -homo-amino acid moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9994aae437aa396bc3895b6e798652
https://pubmed.ncbi.nlm.nih.gov/21560227
https://pubmed.ncbi.nlm.nih.gov/21560227
Publikováno v:
Nucleic Acids Research
The pharmacological disruption of the interaction between the HIV Tat protein and its cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a low susceptibility to drug resistance, but efforts to discover ligands with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c05e230b355addfe8fa501a675831bb
https://www.zora.uzh.ch/id/eprint/54054/
https://www.zora.uzh.ch/id/eprint/54054/