Výsledky vyhledávání - "Krystyna Ossowska"

Akademický článek

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

Autor: Klemencja Berghauzen-Maciejewska, Jadwiga Wardas, Barbara Kosmowska, Urszula Głowacka, Katarzyna Kuter, Krystyna Ossowska

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0117698 (2015)

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour which is reversed by chronic treatment with pramipexol

Externí odkaz: https://doaj.org/article/c90d04b5ea71432d81eb2622b841e6ba

Zobrazit plný text záznamu

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system

Autor: Maria Śmiałowska, Krystyna Ossowska, Katarzyna Kuter

Publikováno v: Pharmacological Reports

Background Prolonged inflammation, oxidative stress, and protein aggregation are important factors contributing to Parkinson’s disease (PD) pathology. A known ROS generator, pesticide paraquat (PQ), was indicated as an environmental substance poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c6ec3b0f9902b82838e5a4df6604e3
https://doi.org/10.1007/s43440-021-00340-1

Zobrazit plný text záznamu

Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor

Autor: Krystyna Ossowska, Jadwiga Wardas, Barbara Kosmowska

Publikováno v: Neurochemical Research

Essential tremor is one of the most common neurological disorders, however, it is not sufficiently controlled with currently available pharmacotherapy. Our recent study has shown that pramipexole, a drug efficient in inhibiting parkinsonian tremor, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e51de94741f2a13cf836d60884cb0c
https://doi.org/10.1007/s11064-020-03010-5

Zobrazit plný text záznamu

Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5′-Chloro-5′-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor

Autor: Jolanta Konieczny, Tomasz Lenda, Krystyna Ossowska, Klemencja Berghauzen-Maciejewska, Barbara Kosmowska, Jadwiga Wardas

Publikováno v: Neuroscience. 429:106-118

The primary cause of harmaline tremor, which is a model of essential tremor (ET) in animals, is excessive activation of olivocerebellar glutamatergic climbing fibers. Our recent study indicated that 5′-chloro-5′-deoxy-(±)-N6-(±)-(endo-norborn-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c667f65745b81100fdd992a303a4537
https://doi.org/10.1016/j.neuroscience.2019.12.045

Zobrazit plný text záznamu

Potential antipsychotic action of the selective agonist of adenosine A1 receptors, 5′-Cl-5′-deoxy-ENBA, in amphetamine and MK-801 rat models

Autor: Krystyna Ossowska, Barbara Kosmowska, Jadwiga Wardas

Publikováno v: Pharmacological Reports

Background Disturbances of dopaminergic and glutamatergic transmissions have been suggested to be involved in the pathomechanisms underlying psychotic symptoms of schizophrenia. In line with this concept, hyperlocomotion induced by the dopaminomimeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ebd3923acc896bdea2d7370e4f8d86
http://europepmc.org/articles/PMC7329802

Zobrazit plný text záznamu

Blockade of adenosine A

Autor: Barbara, Kosmowska, Krystyna, Ossowska, Jadwiga, Wardas

Publikováno v: Behavioural brain research. 417

Tremor is one of the motor symptoms of Parkinson's disease (PD), present also in neuroleptic-induced parkinsonism. Tremulous Jaw Movements (TJMs) are suggested to be a well-validated rodent model of PD resting tremor. TJMs can be induced by typical a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5da61f12140a98d08722c61e85dde268
https://pubmed.ncbi.nlm.nih.gov/34536428

Zobrazit plný text záznamu

Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease

Autor: Klemencja Berghauzen-Maciejewska, Tomasz Lenda, Jolanta Konieczny, Maciej Wieczorek, Jerzy Pieczykolan, Krystyna Ossowska, Mikołaj Matłoka

Publikováno v: European journal of pharmacology. 910

Phosphodiesterase 10A (PDE10A), the enzyme which catalyzes hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), is located almost exclusively in striatal γ-amino-butyric acid (GABA)ergic medium spiny neurons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72808b007fbcd7f0b9ac564b10dac03
https://pubmed.ncbi.nlm.nih.gov/34469756

Zobrazit plný text záznamu

Blockade of adenosine A2A receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures

Autor: Krystyna Ossowska, Jadwiga Wardas, Barbara Kosmowska

Publikováno v: Behavioural Brain Research. 417:113585

Tremor is one of the motor symptoms of Parkinson’s disease (PD), present also in neuroleptic-induced parkinsonism. Tremulous Jaw Movements (TJMs) are suggested to be a well-validated rodent model of PD resting tremor. TJMs can be induced by typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3813c7a840555620e9bac1383010121
https://doi.org/10.1016/j.bbr.2021.113585

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání