Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Krystyna A. Skupinska"'
Autor:
Curtis Harwig, Rossana Wauthy, Renato Skerlj, Fluri Maria Di, Yongbao Zhu, Duane Veale, Dominique Schols, Gary Bridger, Helen Yee, Wen Yang, Wilson Trevor R, David Bogucki, Christopher Ronald Smith, Erik De Clercq, Krystyna A. Skupinska, Jonathon Langille, Jason M. Crawford, Dana Huskens, Ernie Mceachern
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:262-266
An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca(2+) flux inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b434e9cc08b4cd6ef59fcf57d365da
https://doi.org/10.1016/j.bmcl.2010.11.023
https://doi.org/10.1016/j.bmcl.2010.11.023
Publikováno v:
Synlett. 1999:1867-1870
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbcb706e3acb65215e53eb7f6f695fc
https://doi.org/10.1055/s-1999-2986
https://doi.org/10.1055/s-1999-2986
Autor:
Dana Huskens, Ernest J. McEachern, Yongbao Zhu, Helen Yee, Krystyna A. Skupinska, Michael Sartori, Alan Kaller, Gary Bridger, Renato Skerlj, Erik De Clercq, Duane Veale, Ian Baird, Letian Wang, Kate Burrage, Dominique Schols, Wen Yang, Christopher Ronald Smith, Curtis Harwig, Rossana Wauthy
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
A novel series of CXCR4 antagonists were identified based on the substantial redesign of AMD070. These compounds possessed potent anti-HIV-1 activity and showed excellent pharmacokinetics in rat and dog.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb77b6ca0b89a136d84dcf38390783
https://pubmed.ncbi.nlm.nih.gov/21295470
https://pubmed.ncbi.nlm.nih.gov/21295470
Publikováno v:
ChemInform. 37
Mild conditions for the preparation of benzimidazole-2-carboxylates have been developed. Condensation of a substituted 1,2-phenylenediamine with methyl trichloroacetamidate in the presence of TFA rapidly affords the 2-trichloromethylbenzimidazole; hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2d14e34e543e22ee49e5e4303edd8a
https://doi.org/10.1002/chin.200629106
https://doi.org/10.1002/chin.200629106
Publikováno v:
The Journal of organic chemistry. 68(9)
Candida antarctica lipase B has been used to kinetically resolve a structurally diverse series of bicyclic 1-heteroaryl primary amines by enantioselective acetylation. High yields of either enantiomer could be obtained with excellent enantioselectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72450cadb1ea5a7086b59415808ed28
https://pubmed.ncbi.nlm.nih.gov/12713358
https://pubmed.ncbi.nlm.nih.gov/12713358
Publikováno v:
ChemInform. 34
A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd992036321bf11e6e9bd47d1205f82
https://doi.org/10.1002/chin.200314057
https://doi.org/10.1002/chin.200314057
Publikováno v:
HETEROCYCLES. 67:769
Mild conditions for the preparation of benzimidazole-2-carboxylates have been developed. Condensation of a substituted 1,2-phenylenediamine with methyl trichloroacetamidate in the presence of TFA rapidly affords the 2-trichloromethylbenzimidazole; hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c128cf710e7a313e7b872419681e4741
https://doi.org/10.3987/com-05-s(t)45
https://doi.org/10.3987/com-05-s(t)45